Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

[1]  Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. , 1965, Lancet.

[2]  V. Tirlapur.  Relationship of ventricular ectopy to nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease. , 1985, The American journal of medicine.

[3]  H. Moldofsky,et al.  Role of daytime hypoxemia in the pathogenesis of right heart failure in the obstructive sleep apnea syndrome. , 2015, The American review of respiratory disease.

[4]  N. Anthonisen,et al.  Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. , 1987, Annals of internal medicine.

[5]  F. Speizer,et al.  The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample. , 1987, The American review of respiratory disease.

[6]  G. Guyatt,et al.  A measure of quality of life for clinical trials in chronic lung disease. , 1987, Thorax.

[7]  J. Krieger,et al.  Daytime pulmonary hypertension in patients with obstructive sleep apnea syndrome. , 1988, The American review of respiratory disease.

[8]  C. Husten,et al.  How to help your patients stop smoking. , 1978, American family physician.

[9]  K. Godfrey,et al.  Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. , 1991, BMJ.

[10]  K. Murphy,et al.  The language of breathlessness. Use of verbal descriptors by patients with cardiopulmonary disease. , 1991, The American review of respiratory disease.

[11]  P. Jones,et al.  A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. , 1992, The American review of respiratory disease.

[12]  K. Chapman,et al.  Physician perceptions and management of COPD. , 1993, Chest.

[13]  E. Wouters,et al.  Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. , 1993, The American review of respiratory disease.

[14]  J. Wedzicha,et al.  Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease , 1993, The Lancet.

[15]  A. Thomson,et al.  Value of theophylline treatment in patients handicapped by chronic obstructive lung disease. , 1993, Thorax.

[16]  T. Meyer,et al.  Noninvasive Positive Pressure Ventilation To Treat Respiratory Failure , 1994, Annals of Internal Medicine.

[17]  W. Bailey,et al.  Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. , 1995, JAMA.

[18]  K. Nichol,et al.  The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. , 1994, The New England journal of medicine.

[19]  W. Dupont,et al.  A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. , 1994, The Journal of infectious diseases.

[20]  N. Hill,et al.  Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure. , 1995, American journal of respiratory and critical care medicine.

[21]  M. Wysocki,et al.  Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. , 1995, The New England journal of medicine.

[22]  I. Tager,et al.  Maternal smoking during pregnancy. Effects on lung function during the first 18 months of life. , 1995, American journal of respiratory and critical care medicine.

[23]  D. Simel,et al.  Does the clinical examination predict airflow limitation? , 1995, JAMA.

[24]  ScienceDirect.  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. , 1996 .

[25]  J. Connett,et al.  Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. , 1996, American journal of respiratory and critical care medicine.

[26]  J. Barberà,et al.  Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease , 1996, The Lancet.

[27]  J. Crowley,et al.  Controlled trial of oral prednisone in outpatients with acute COPD exacerbation. , 1996, American journal of respiratory and critical care medicine.

[28]  J. M. FitzGerald,et al.  Bronchodilator delivery in acute airflow obstruction. A meta-analysis. , 1997, Archives of internal medicine.

[29]  Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting. , 1997, Bulletin of the World Health Organization.

[30]  J. Collet,et al.  Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of Acute Respiratory Infection by an Immunostimulant. , 1997, American journal of respiratory and critical care medicine.

[31]  T. Seemungal,et al.  Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. , 1998, American journal of respiratory and critical care medicine.

[32]  W. Stalman,et al.  Is immunising all patients with chronic lung disease in the community against influenza cost effective? Evidence from a general practice based clinical prospective cohort study in Utrecht, The Netherlands. , 1998, Journal of epidemiology and community health.

[33]  R. Rodríguez-Roisín,et al.  Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. , 1998, American journal of respiratory and critical care medicine.

[34]  P. Lange,et al.  Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial , 1999, The Lancet.

[35]  D. Postma,et al.  Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. , 1999, The New England journal of medicine.

[36]  P. Jones,et al.  Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease , 1999, Thorax.

[37]  F. Maltais,et al.  Aerobic and strength training in patients with chronic obstructive pulmonary disease. , 1999, American journal of respiratory and critical care medicine.

[38]  L. Davies,et al.  Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial , 1999, The Lancet.

[39]  M. Miravitlles,et al.  Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD. , 1999, Chest.

[40]  H A Vrooman,et al.  A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy. , 1999, American journal of respiratory and critical care medicine.

[41]  Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease, COPD, and nocturnal hypoventilation--a consensus conference report. , 1999, Chest.

[42]  D. Niewoehner,et al.  Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. , 1999, The New England journal of medicine.

[43]  R. Stockley,et al.  Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. , 2000, Chest.

[44]  Michael C. Fiore,et al.  A Clinical Practice Guideline for Treating Tobacco Use and Dependence A US Public Health Service Report , 2000 .

[45]  T. Lasserson,et al.  Lung volume reduction surgery for diffuse emphysema. , 2000, The Cochrane database of systematic reviews.

[46]  A. Crockett,et al.  Domiciliary oxygen for chronic obstructive pulmonary disease. , 2005, The Cochrane database of systematic reviews.

[47]  tefan,et al.  LONG-TERM TREATMENT WITH INHALED BUDESONIDE IN PERSONS WITH MILD CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHO CONTINUE SMOKING , 2000 .

[48]  Dirkje S Postma,et al.  Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study , 2000, The Lancet.

[49]  S. Spencer,et al.  Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial , 2000, BMJ : British Medical Journal.

[50]  M. Fiore.  A Clinical Practice Guideline for Treating Tobacco Use and Dependence A US Public Health Service Report , 2000 .

[51]  P. Plant,et al.  Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial , 2000, The Lancet.

[52]  T. Seemungal,et al.  Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. , 2000, American journal of respiratory and critical care medicine.

[53]  B. Celli,et al.  Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD. , 2000, Chest.

[54]  R. Wood‐Baker,et al.  Influenza vaccine for patients with chronic obstructive pulmonary disease. , 2006, The Cochrane database of systematic reviews.

[55]  Steven Piantadosi,et al.  Patients at high risk of death after lung-volume-reduction surgery. , 2001, The New England journal of medicine.

[56]  P. Jones,et al.  Health status measurement in chronic obstructive pulmonary disease , 2001, Thorax.

[57]  R. Zuwallack,et al.  Salmeterol plus theophylline combination therapy in the treatment of COPD. , 2001, Chest.

[58]  R. Masterton,et al.  Randomized, double-blind study comparing 5- and 7-day regimens of oral levofloxacin in patients with acute exacerbation of chronic bronchitis. , 2001, International journal of antimicrobial agents.

[59]  F. Abroug,et al.  Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomised placebo-controlled trial , 2001, The Lancet.

[60]  P. Anderson,et al.  Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial , 2001, The Lancet.

[61]  F. Maltais,et al.  Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. , 2002, American journal of respiratory and critical care medicine.

[62]  D. Postma,et al.  Chronic obstructive pulmonary disease. , 2002, Clinical evidence.

[63]  Toru Oga,et al.  Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. , 2002, Chest.

[64]  P. Jones,et al.  Oral theophylline for chronic obstructive pulmonary disease. , 2002, The Cochrane database of systematic reviews.

[65]  A. Corrado,et al.  The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients , 2002, European Respiratory Journal.

[66]  M. Antonelli,et al.  Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial , 2002, Intensive Care Medicine.

[67]  J. van der Palen,et al.  Effect of discontinuation of inhaled corticosteroids in patients with chronic obstructive pulmonary disease: the COPE study. , 2002, American journal of respiratory and critical care medicine.

[68]  S. Antoniu,et al.  Hospitalizations and mortality in the Lung Health Study , 2002, Expert review of pharmacoeconomics & outcomes research.

[69]  J. Toral,et al.  Comparison of effects of strength and endurance training in patients with chronic obstructive pulmonary disease. , 2002, American journal of respiratory and critical care medicine.

[70]  O. Johnell,et al.  Bone mineral density in patients with chronic obstructive pulmonary disease treated with budesonide Turbuhaler® , 2002, European Respiratory Journal.

[71]  J. Wedzicha,et al.  Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis , 2003, BMJ : British Medical Journal.

[72]  Steven Piantadosi,et al.  A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. , 2003, The New England journal of medicine.

[73]  B. Rowe,et al.  Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomised trials , 2003, BMJ : British Medical Journal.

[74]  I. Stiell,et al.  Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. , 2003, The New England journal of medicine.

[75]  R. Pauwels,et al.  Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial , 2003, The Lancet.

[76]  Andrew J. White,et al.  Chronic obstructive pulmonary disease • 6: The aetiology of exacerbations of chronic obstructive pulmonary disease , 2003, Thorax.

[77]  R. Sansores,et al.  Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease , 2003, European Respiratory Journal.

[78]  P. Calverley,et al.  Maintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease , 2003, European Respiratory Journal.

[79]  K. N. Maranetra,et al.  Economic evaluation of influenza vaccination in Thai chronic obstructive pulmonary disease patients. , 2003, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[80]  E. Salpeter,et al.  Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. , 2004, Chest.

[81]  B. Make,et al.  Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD , 2004, European Respiratory Journal.

[82]  W. MacNee,et al.  Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper , 2004, European Respiratory Journal.

[83]  W. Dejsomritrutai,et al.  Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. , 2004, Chest.

[84]  Ciro Casanova,et al.  The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.

[85]  J. Wedzicha,et al.  Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease. , 2004, American journal of respiratory and critical care medicine.

[86]  Hospice.  National Consensus Project for Quality Palliative Care: Clinical Practice Guidelines for quality palliative care, executive summary. , 2004, Journal of palliative medicine.

[87]  G. Zeng,et al.  Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease. , 2004, Chinese medical journal.

[88]  A. Ionescu,et al.  Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. , 2004, American journal of respiratory and critical care medicine.

[89]  Stefano Guerra,et al.  Asthma as a risk factor for COPD in a longitudinal study. , 2004, Chest.

[90]  L. Stead,et al.  Physician advice for smoking cessation. , 2004, The Cochrane database of systematic reviews.

[91]  P. Calverley,et al.  Intravenous aminophylline in patients admitted to hospital with non-acidotic exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial , 2005, Thorax.

[92]  A. Torres,et al.  Guidelines for the management of adult lower respiratory tract infections , 2005, European Respiratory Journal.

[93]  D. Lawlor,et al.  Association of birth weight with adult lung function: findings from the British Women’s Heart and Health Study and a meta-analysis , 2005, Thorax.

[94]  R. Casaburi,et al.  Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. , 2005, Chest.

[95]  D. Postma,et al.  Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial , 2005, Thorax.

[96]  J. Bourbeau,et al.  Inhaled tiotropium for stable chronic obstructive pulmonary disease. , 2000, The Cochrane database of systematic reviews.

[97]  M. Ezzati.  Indoor air pollution and health in developing countries , 2005, The Lancet.

[98]  A. Hansell,et al.  Patterns of comorbidities in newly diagnosed COPD and asthma in primary care. , 2005, Chest.

[99]  T. Todisco,et al.  Mild prematurity and respiratory functions , 2005, European Journal of Pediatrics.

[100]  M. Martínez-García,et al.  Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease , 2005, Thorax.

[101]  Ø. Borgan,et al.  Lung transplantation in patients with chronic obstructive pulmonary disease in a national cohort is without obvious survival benefit. , 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[102]  N. Zhong,et al.  Positive benefits of theophylline in a randomized, double‐blind, parallel‐group, placebo‐controlled study of low‐dose, slow‐release theophylline in the treatment of COPD for 1 year , 2006, Respirology.

[103]  S. K. Chhabra,et al.  Chronic obstructive pulmonary disease and cardiovascular disease. , 2006, The Indian journal of chest diseases & allied sciences.

[104]  S. Johnston,et al.  Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. , 2006, American journal of respiratory and critical care medicine.

[105]  B. Celli,et al.  Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD. , 2006, Chest.

[106]  J. Curtis,et al.  Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease , 2006, Expert review of anti-infective therapy.

[107]  J. Garcia-Aymerich,et al.  Wood smoke exposure and risk of chronic obstructive pulmonary disease , 2006, European Respiratory Journal.

[108]  R. Rodríguez-Roisín,et al.  Antibiotics for exacerbations of chronic obstructive pulmonary disease. , 2011, The Cochrane database of systematic reviews.

[109]  N. Anthonisen,et al.  Mortality in COPD: role of comorbidities , 2006, European Respiratory Journal.

[110]  B. Smith,et al.  Ipratropium bromide versus long-acting beta-2 agonists for stable chronic obstructive pulmonary disease. , 2006, The Cochrane database of systematic reviews.

[111]  S. Rennard,et al.  The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. , 2007, American journal of respiratory and critical care medicine.

[112]  T. Seemungal,et al.  COPD exacerbations: defining their cause and prevention , 2007, The Lancet.

[113]  C. Jiang,et al.  Passive smoking exposure and risk of COPD among adults in China: the Guangzhou Biobank Cohort Study , 2007, The Lancet.

[114]  T. Ng,et al.  Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life. , 2007, Archives of internal medicine.

[115]  G. Valdivia,et al.  Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America , 2007, European Respiratory Journal.

[116]  T. Lasserson,et al.  Inhaled corticosteroids for stable chronic obstructive pulmonary disease. , 2007, The Cochrane database of systematic reviews.

[117]  Gorka Bastarrika,et al.  Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. , 2007, Chest.

[118]  D. Mannino,et al.  International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study , 2007, The Lancet.

[119]  David G. Anderson,et al.  Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. , 2007, American journal of respiratory and critical care medicine.

[120]  Bartolome Celli,et al.  Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. , 2007, The New England journal of medicine.

[121]  Stefano Guerra,et al.  Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study , 2007, The Lancet.

[122]  S. Cendon,et al.  Effect of theophylline associated with short-acting or long-acting inhaled beta2-agonists in patients with stable chronic obstructive pulmonary disease: a systematic review. , 2007, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.

[123]  D. Postma,et al.  Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study. , 2007, Chest.

[124]  P. Calverley,et al.  Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. , 2008, American journal of respiratory and critical care medicine.

[125]  R. Casaburi,et al.  Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients , 2008, International journal of chronic obstructive pulmonary disease.

[126]  J. Maurer.  Tiotropium in Combination with Placebo, Salmeterol, or Fluticasone-Salmeterol for Treatment of Chronic Obstructive Pulmonary Disease: A Randomized Trial , 2008 .

[127]  M. Decramer,et al.  A 4-year trial of tiotropium in chronic obstructive pulmonary disease. , 2008, The New England journal of medicine.

[128]  B. O'connor,et al.  Superiority of “triple” therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD , 2008, Thorax.

[129]  K. Rabe,et al.  Complex chronic comorbidities of COPD , 2008, European Respiratory Journal.

[130]  D. Mannino,et al.  Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD , 2008, European Respiratory Journal.

[131]  A. Ionescu,et al.  What community measurements can be used to predict bone disease in patients with COPD? , 2008, Respiratory medicine.

[132]  T. Seemungal,et al.  Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. , 2008, American journal of respiratory and critical care medicine.

[133]  Philippe Ravaud,et al.  Survival after bilateral versus single lung transplantation for patients with chronic obstructive pulmonary disease: a retrospective analysis of registry data , 2008, The Lancet.

[134]  David O Wilson,et al.  Association of radiographic emphysema and airflow obstruction with lung cancer. , 2008, American journal of respiratory and critical care medicine.

[135]  M. Decramer,et al.  Bronchodilator responsiveness in patients with COPD , 2008, European Respiratory Journal.

[136]  R. Cumming,et al.  Use of inhaled and oral corticosteroids and the long-term risk of cataract. , 2009, Ophthalmology.

[137]  Niels H Chavannes,et al.  Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: the DOSE Index. , 2009, American journal of respiratory and critical care medicine.

[138]  R. Murray,et al.  Smoking cessation in chronic obstructive pulmonary disease. , 2009, Respiratory medicine.

[139]  D. Mannino,et al.  The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. , 2009, American journal of respiratory and critical care medicine.

[140]  F. Martinez,et al.  Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials , 2009, The Lancet.

[141]  T. Bregenzer,et al.  Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. , 2009, JAMA.

[142]  P. J. Barnes,et al.  Systemic manifestations and comorbidities of COPD , 2009, European Respiratory Journal.

[143]  Ulrike Held,et al.  Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index , 2009, The Lancet.

[144]  W. Vollmer,et al.  Marijuana and chronic obstructive lung disease: a population-based study , 2009, Canadian Medical Association Journal.

[145]  J. Soriano,et al.  Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities , 2009, Thorax.

[146]  C. Jenkins,et al.  Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. , 2009, Chest.

[147]  R. Stockley,et al.  Augmentation Therapy for α1 Antitrypsin Deficiency: A Meta-Analysis , 2009, COPD.

[148]  Nicolas Roche,et al.  Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. , 2009, Chest.

[149]  A. Dirksen,et al.  Exploring the role of CT densitometry: a randomised study of augmentation therapy in α1-antitrypsin deficiency , 2009, European Respiratory Journal.

[150]  T. Welte,et al.  Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease. , 2009, American journal of respiratory and critical care medicine.

[151]  J. Steurer,et al.  Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. , 2009, The Cochrane database of systematic reviews.

[152]  R. Wood‐Baker,et al.  Effect of high flow oxygen on mortality in chronic obstructive pulmonary disease patients in prehospital setting: randomised controlled trial , 2010, BMJ : British Medical Journal.

[153]  T. Omachi,et al.  Influence of anxiety on health outcomes in COPD , 2010, Thorax.

[154]  O. Keene,et al.  Temporal clustering of exacerbations in chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[155]  M. Cazzola,et al.  The scientific rationale for combining long-acting beta2-agonists and muscarinic antagonists in COPD. , 2010, Pulmonary pharmacology & therapeutics.

[156]  J. Soriano,et al.  Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. , 2010, American journal of respiratory and critical care medicine.

[157]  R. D. de Haan,et al.  Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped scoring method. , 2010, Journal of aerosol medicine and pulmonary drug delivery.

[158]  Edwin K Silverman,et al.  Characterisation of COPD heterogeneity in the ECLIPSE cohort , 2010, Respiratory research.

[159]  J. Wedzicha,et al.  Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial , 2010, Respiratory research.

[160]  T. Michele,et al.  The safety of tiotropium--the FDA's conclusions. , 2010, The New England journal of medicine.

[161]  Gordon H. Guyatt,et al.  Prevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary care , 2010, Canadian Medical Association Journal.

[162]  R. Hoogenveen,et al.  Case fatality of COPD exacerbations: a meta-analysis and statistical modelling approach , 2010, European Respiratory Journal.

[163]  L. Fabbri,et al.  Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents , 2010, Respiratory research.

[164]  J. Vestbo,et al.  The prognostic importance of lung function in patients admitted with heart failure , 2010, European journal of heart failure.

[165]  J. Wedzicha,et al.  Susceptibility to exacerbation in chronic obstructive pulmonary disease. , 2010, The New England journal of medicine.

[166]  P. Davies,et al.  Tuberculosis, bronchiectasis and chronic airflow obstruction , 2010, Respirology.

[167]  Stephan von Haehling,et al.  Cachexia as a major underestimated and unmet medical need: facts and numbers , 2010, Journal of cachexia, sarcopenia and muscle.

[168]  S. Suissa,et al.  Inhaled corticosteroids and the risks of diabetes onset and progression. , 2010, The American journal of medicine.

[169]  Edwin K Silverman,et al.  An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[170]  G. McLennan,et al.  A randomized study of endobronchial valves for advanced emphysema. , 2010, The New England journal of medicine.

[171]  C. Jenkins,et al.  Cardiovascular events in patients with COPD: TORCH Study results , 2010, Thorax.

[172]  D. Mannino,et al.  Lung function impairment, COPD hospitalisations and subsequent mortality , 2011, Thorax.

[173]  D. Jarvis,et al.  Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults. , 2011, American journal of respiratory and critical care medicine.

[174]  M. Miravitlles,et al.  Sputum colour and bacteria in chronic bronchitis exacerbations: a pooled analysis , 2011, European Respiratory Journal.

[175]  John Connett,et al.  Azithromycin for prevention of exacerbations of COPD. , 2011, The New England journal of medicine.

[176]  F. Martinez,et al.  The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery. , 2011, American journal of respiratory and critical care medicine.

[177]  David O Wilson,et al.  Quantitative Computed Tomography Analysis, Airflow Obstruction, and Lung Cancer in the Pittsburgh Lung Screening Study , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[178]  A. Høiseth,et al.  Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease , 2011, Thorax.

[179]  Christopher E Brightling,et al.  Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. , 2011, American journal of respiratory and critical care medicine.

[180]  M. Tsukino,et al.  Predictive properties of different multidimensional staging systems in patients with chronic obstructive pulmonary disease , 2011, International journal of chronic obstructive pulmonary disease.

[181]  C. Gatsonis,et al.  Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening , 2012 .

[182]  J. Hokanson,et al.  The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. , 2011, Chest.

[183]  A. Anzueto,et al.  Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support. , 2011, Archives of internal medicine.

[184]  Stephanie J. C. Taylor,et al.  Withdrawal of inhaled corticosteroids in individuals with COPD - a systematic review and comment on trial methodology , 2011, Respiratory research.

[185]  J. Walusiak‐Skorupa,et al.  Faculty Opinions recommendation of COPD in never smokers: results from the population-based burden of obstructive lung disease study. , 2011 .

[186]  E. Akl,et al.  Effects of water-pipe smoking on lung function: a systematic review and meta-analysis. , 2011, Chest.

[187]  R. Cavallazzi,et al.  Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies , 2011, Thorax.

[188]  K. Rabe,et al.  Tiotropium versus salmeterol for the prevention of exacerbations of COPD. , 2011, The New England journal of medicine.

[189]  C. Bausewein,et al.  Levodropropizine in the Management of Cough Associated with Cancer or Nonmalignant Chronic Disease–A Systematic Review , 2011, Journal of pain & palliative care pharmacotherapy.

[190]  D. Slebos,et al.  Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial , 2011, The Lancet.

[191]  S. Rennard,et al.  Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trial. , 2011, Chest.

[192]  David Gur,et al.  Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort. , 2011, American journal of respiratory and critical care medicine.

[193]  Nicola A Hanania,et al.  Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. , 2011, Radiology.

[194]  P. Jones,et al.  Creating scenarios of the impact of copd and their relationship to copd assessment test (CAT™) scores , 2011, BMC pulmonary medicine.

[195]  Marco Lodi,et al.  Inhaler mishandling remains common in real life and is associated with reduced disease control. , 2011, Respiratory medicine.

[196]  D. Mannino,et al.  Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008. , 2012, American journal of respiratory and critical care medicine.

[197]  C. Cates,et al.  Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease. , 2012, The Cochrane database of systematic reviews.

[198]  Christopher E Brightling,et al.  Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. , 2012, American journal of respiratory and critical care medicine.

[199]  B. Celli,et al.  Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. , 2012, American journal of respiratory and critical care medicine.

[200]  T. Lasserson,et al.  Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease. , 2012, The Cochrane database of systematic reviews.

[201]  D. Niewoehner,et al.  Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. , 2012, Respiratory medicine.

[202]  Stefan Störk,et al.  "GOLD or lower limit of normal definition? a comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study" , 2012, Respiratory Research.

[203]  J. Brophy,et al.  Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort. , 2012, Chest.

[204]  A. Rahmel,et al.  The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. , 2012, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[205]  Meilan K. Han,et al.  Pulmonary arterial enlargement and acute exacerbations of COPD. , 2012, The New England journal of medicine.

[206]  P. Poole,et al.  Tiotropium versus placebo for chronic obstructive pulmonary disease. , 2012, The Cochrane database of systematic reviews.

[207]  M. Decramer,et al.  High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial , 2012 .

[208]  M. Cazzola,et al.  Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes. , 2012, Primary care respiratory journal : journal of the General Practice Airways Group.

[209]  L. Edwards,et al.  Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease , 2012, Thorax.

[210]  H. Sørensen,et al.  Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis , 2012, Thorax.

[211]  P. Enright,et al.  Pro-arrhythmic and pro-ischaemic effects of inhaled anticholinergic medications , 2012, Thorax.

[212]  S. D. Lee,et al.  Comparison of tiotropium plus fluticasone propionate/salmeterol with tiotropium in COPD: a randomized controlled study. , 2012, Respiratory medicine.

[213]  Grant D. Huang,et al.  A Comprehensive Care Management Program to Prevent Chronic Obstructive Pulmonary Disease Hospitalizations , 2012, Annals of Internal Medicine.

[214]  D. Au,et al.  A randomized trial to improve communication about end-of-life care among patients with COPD. , 2012, Chest.

[215]  C. Janson,et al.  The Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index is predictive of mortality in COPD. , 2012, Primary care respiratory journal : journal of the General Practice Airways Group.

[216]  F. Martinez,et al.  Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials. , 2013, The Lancet. Respiratory medicine.

[217]  Y. Hasegawa,et al.  COPD and disease-specific health status in a working population , 2013, Respiratory Research.

[218]  M. Martínez-García,et al.  Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. , 2013, American journal of respiratory and critical care medicine.

[219]  James D. Chalmers,et al.  Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease. , 2013, Annals of the American Thoracic Society.

[220]  J. Wedzicha,et al.  Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study. , 2013, The Lancet. Respiratory medicine.

[221]  Edwin K Silverman,et al.  GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. , 2013, The Lancet. Respiratory medicine.

[222]  M. Briel,et al.  Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. , 2013, JAMA.

[223]  B. Nordestgaard,et al.  Characteristics and outcomes of chronic obstructive pulmonary disease in never smokers in Denmark: a prospective population study. , 2013, The Lancet. Respiratory medicine.

[224]  P. Poole,et al.  Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus inhaled corticosteroids alone for chronic obstructive pulmonary disease. , 2013, The Cochrane database of systematic reviews.

[225]  P. Bower,et al.  Effect of telehealth on quality of life and psychological outcomes over 12 months (Whole Systems Demonstrator telehealth questionnaire study): nested study of patient reported outcomes in a pragmatic, cluster randomised controlled trial , 2013, BMJ : British Medical Journal.

[226]  Martijn A Spruit,et al.  Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. , 2013, American journal of respiratory and critical care medicine.

[227]  J. Yim,et al.  Use of inhaled corticosteroids and the risk of tuberculosis , 2013, Thorax.

[228]  G. Pledger,et al.  Tiotropium Respimat inhaler and the risk of death in COPD. , 2013, The New England journal of medicine.

[229]  M. Decramer,et al.  Dual bronchodilation with QVA149 reduces patient-reported dyspnoea in COPD: the BLAZE study , 2013, European Respiratory Journal.

[230]  H. Tange,et al.  Early detection of COPD in general practice: implementation, workload and socioeconomic status. A mixed methods observational study , 2013, Primary Care Respiratory Journal: Journal of the General Practice Airways Group.

[231]  L. Edwards,et al.  Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. , 2013, Respiratory medicine.

[232]  R. Ferrari,et al.  Impact of a recent hospitalization on treatment and prognosis of ST-segment elevation myocardial infarction. , 2013, International journal of cardiology.

[233]  Michael Brauer,et al.  Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality. , 2013, American journal of respiratory and critical care medicine.

[234]  N. Chavannes,et al.  Integrated disease management interventions for patients with chronic obstructive pulmonary disease. , 2013, The Cochrane database of systematic reviews.

[235]  Phung Anh Nguyen,et al.  Influenza vaccination and reduction in risk of ischemic heart disease among chronic obstructive pulmonary elderly , 2013, Comput. Methods Programs Biomed..

[236]  J. Barberà,et al.  Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial , 2013, European Respiratory Journal.

[237]  R. Perera,et al.  Pharmacological interventions for smoking cessation: an overview and network meta-analysis. , 2013, The Cochrane database of systematic reviews.

[238]  N. Roche,et al.  High-risk patients following hospitalisation for an acute exacerbation of COPD , 2013, European Respiratory Journal.

[239]  Thierry Troosters,et al.  An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. , 2013, American journal of respiratory and critical care medicine.

[240]  M. Velloso,et al.  Evaluation of effects of shoulder girdle training on strength and performance of activities of daily living in patients with chronic obstructive pulmonary disease , 2013, International Journal of COPD.

[241]  M. Decramer,et al.  Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study. , 2013, The Lancet. Respiratory medicine.

[242]  N. Chavannes,et al.  Effectiveness of integrated disease management for primary care chronic obstructive pulmonary disease patients: results of cluster randomised trial , 2014, BMJ : British Medical Journal.

[243]  B. Lipworth,et al.  Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial. , 2014, The Lancet. Respiratory medicine.

[244]  G. Criner,et al.  Home non-invasive ventilation use following acute hypercapnic respiratory failure in COPD. , 2014, Respiratory medicine.

[245]  G. Kirk,et al.  HIV-associated obstructive lung diseases: insights and implications for the clinician. , 2014, The Lancet. Respiratory medicine.

[246]  Meilan K. Han,et al.  Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. , 2014, The New England journal of medicine.

[247]  C. Bullen,et al.  Electronic cigarettes for smoking cessation and reduction. , 2014, The Cochrane database of systematic reviews.

[248]  Dennis Emralino Dantic,et al.  A critical review of the effectiveness of ‘teach-back’ technique in teaching COPD patients self-management using respiratory inhalers , 2014 .

[249]  J. Soriano,et al.  Short- and medium-term prognosis in patients hospitalized for COPD exacerbation: the CODEX index. , 2014, Chest.

[250]  M. Polkey,et al.  Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (The BeLieVeR-HIFi trial): study design and rationale , 2014, Thorax.

[251]  D. Price,et al.  Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study , 2014, Respiratory Research.

[252]  F. Herrmann,et al.  Can early introduction of specialized palliative care limit intensive care, emergency and hospital admissions in patients with severe and very severe COPD? a randomized study , 2014, BMC Palliative Care.

[253]  J. E. Hansen,et al.  Counterpoint: Is an increase in FEV₁ and/or FVC ≥ 12% of control and ≥ 200 mL the best way to assess positive bronchodilator response? No. , 2014, Chest.

[254]  Jun She,et al.  Chinese water-pipe smoking and the risk of COPD. , 2014, Chest.

[255]  P. Frith,et al.  Self management for patients with chronic obstructive pulmonary disease. , 2014, The Cochrane database of systematic reviews.

[256]  N. Metzdorf,et al.  Does the 2013 GOLD classification improve the ability to predict lung function decline, exacerbations and mortality: a post-hoc analysis of the 4-year UPLIFT trial , 2014, BMC Pulmonary Medicine.

[257]  D. Matamis,et al.  Targeting occult heart failure in intensive care unit patients with acute chronic obstructive pulmonary disease exacerbation: effect on outcome and quality of life. , 2014, Journal of critical care.

[258]  M. Decramer,et al.  Withdrawal of inhaled glucocorticoids and exacerbations of COPD. , 2014, The New England journal of medicine.

[259]  E. Regan,et al.  Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort , 2014, Respiratory Research.

[260]  C. Whitney,et al.  Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Adults Aged ≥65 Years: Recommendations of the Advisory Committee on Immunization Practices (ACIP) , 2014, MMWR. Morbidity and mortality weekly report.

[261]  N. Zhong,et al.  Lung Function and Incidence of Chronic Obstructive Pulmonary Disease after Improved Cooking Fuels and Kitchen Ventilation: A 9-Year Prospective Cohort Study , 2014, PLoS medicine.

[262]  Y. Lacasse,et al.  Nocturnal noninvasive positive pressure ventilation in stable COPD: a systematic review and individual patient data meta-analysis. , 2014, Respiratory medicine.

[263]  H. Hoogsteden,et al.  Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial. , 2014, The Lancet. Respiratory medicine.

[264]  J. Hallas,et al.  Statin use and exacerbations in individuals with chronic obstructive pulmonary disease , 2014, Thorax.

[265]  J. Vonk,et al.  Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study , 2014, Thorax.

[266]  M. Puhan,et al.  Mortality of patients with COPD participating in chronic disease management programmes: a happy end? , 2014, Thorax.

[267]  Stefano Nava,et al.  Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. , 2014, The Lancet. Respiratory medicine.

[268]  Sally J. Singh,et al.  An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial , 2014, BMJ : British Medical Journal.

[269]  B. Ternestedt,et al.  “The unpredictable death”—The last year of life for patients with advanced COPD: Relatives' stories , 2014, Palliative and Supportive Care.

[270]  C. Nordeen.  Use of Inhaled Corticosteroids in Patients With COPD and the Risk of TB and Influenza: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2014 .

[271]  Charlotte Suppli Ulrik,et al.  Effect of tele health care on exacerbations and hospital admissions in patients with chronic obstructive pulmonary disease: a randomized clinical trial , 2015, International journal of chronic obstructive pulmonary disease.

[272]  B. Celli,et al.  Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. , 2015, American journal of respiratory and critical care medicine.

[273]  M. Cazzola,et al.  Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis , 2015, European Respiratory Review.

[274]  N. Maimon,et al.  The Association Between Hospital Readmission and Pulmonologist Follow-up Visits in Patients With COPD. , 2015, Chest.

[275]  G. Marks,et al.  Tuberculosis and chronic respiratory disease: a systematic review. , 2015, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[276]  A. Melani.  Long-acting muscarinic antagonists , 2015, Expert review of clinical pharmacology.

[277]  J. Bourbeau,et al.  Clinical Relevance of Fixed Ratio vs Lower Limit of Normal of FEV1/FVC in COPD: Patient-Reported Outcomes From the CanCOLD Cohort , 2015, The Annals of Family Medicine.

[278]  Dave Singh,et al.  Tiotropium + olodaterol shows clinically meaningful improvements in quality of life. , 2015, Respiratory medicine.

[279]  F. Martinez,et al.  Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial , 2015, The Lancet.

[280]  R. Casaburi,et al.  Phenotype of normal spirometry in an aging population. , 2015, American journal of respiratory and critical care medicine.

[281]  Alice M Turner,et al.  Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data. , 2015, The Lancet. Respiratory medicine.

[282]  G. Washko,et al.  A randomised trial of lung sealant versus medical therapy for advanced emphysema , 2015, European Respiratory Journal.

[283]  Berend C Stoel,et al.  Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial , 2015, The Lancet.

[284]  S. Parthasarathy,et al.  Retrospective Assessment of Home Ventilation to Reduce Rehospitalization in Chronic Obstructive Pulmonary Disease. , 2015, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[285]  D. Postma,et al.  Relapse in FEV1 Decline After Steroid Withdrawal in COPD. , 2015, Chest.

[286]  P. Frith,et al.  Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial , 2015, Thorax.

[287]  Meilan K. Han,et al.  Clinical and Radiologic Disease in Smokers With Normal Spirometry. , 2015, JAMA internal medicine.

[288]  F. Martinez,et al.  Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD. , 2015, Annals of the American Thoracic Society.

[289]  Y. Kim,et al.  The Effectiveness of Anti-leukotriene Agents in Patients with COPD: A Systemic Review and Meta-analysis , 2015, Lung.

[290]  J. Wedzicha,et al.  Blood Eosinophils: A Biomarker of Response to Extrafine Beclomethasone/Formoterol in Chronic Obstructive Pulmonary Disease. , 2015, American journal of respiratory and critical care medicine.

[291]  Hayden McRobbie,et al.  E-cigarettes: an evidence update. A report commissioned by Public Health England. , 2015 .

[292]  Shaf Keshavjee,et al.  A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. , 2015, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[293]  J. Hallas,et al.  Gastro‐esophageal reflux disease and exacerbations in chronic obstructive pulmonary disease , 2015, Respirology.

[294]  G. Diette,et al.  Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease. , 2015, American journal of respiratory and critical care medicine.

[295]  E. V. van Rikxoort,et al.  Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation. , 2015, The New England journal of medicine.

[296]  C. Roberts,et al.  Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit , 2015, European Respiratory Journal.

[297]  M. Scorsetti,et al.  Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography. , 2015, American journal of respiratory and critical care medicine.

[298]  Edwin K Silverman,et al.  Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. , 2015, Annals of the American Thoracic Society.

[299]  E. Bateman,et al.  Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT) , 2015, Respiratory Research.

[300]  Y. Oh,et al.  Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease , 2015, International journal of chronic obstructive pulmonary disease.

[301]  G. Criner,et al.  Surgical Approaches to Treating Emphysema: Lung Volume Reduction Surgery, Bullectomy, and Lung Transplantation , 2015, Seminars in Respiratory and Critical Care Medicine.

[302]  E. Kerwin,et al.  FLIGHT1 and FLIGHT2: Efficacy and Safety of QVA149 (Indacaterol/Glycopyrrolate) versus Its Monocomponents and Placebo in Patients with Chronic Obstructive Pulmonary Disease. , 2015, American journal of respiratory and critical care medicine.

[303]  Erratum: reduced bone density and vertebral fractures in smokers. men and COPD patients at increased risk. , 2015, Annals of the American Thoracic Society.

[304]  P. Kvale,et al.  Predischarge bundle for patients with acute exacerbations of COPD to reduce readmissions and ED visits: a randomized controlled trial. , 2015, Chest.

[305]  Sally J. Singh,et al.  Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis. , 2015, Health technology assessment.

[306]  R. Casaburi,et al.  Phenotype of Spirometric Impairment in an Aging Population. , 2016, American journal of respiratory and critical care medicine.

[307]  K. Rabe,et al.  Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. , 2016, American journal of respiratory and critical care medicine.

[308]  Robert West,et al.  Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends , 2016, British Medical Journal.

[309]  C. Marquette,et al.  Lung Volume Reduction Coil Treatment vs Usual Care in Patients With Severe Emphysema: The REVOLENS Randomized Clinical Trial. , 2016, JAMA.

[310]  R. Ferrence,et al.  Electronic Cigarettes for Smoking Cessation: A Systematic Review. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[311]  E. Kerwin,et al.  Efficacy and Safety of Umeclidinium Added to Fluticasone Propionate/Salmeterol in Patients with COPD: Results of Two Randomized, Double-Blind Studies , 2015, COPD.

[312]  R. Hancox,et al.  Cardiac dysfunction during exacerbations of chronic obstructive pulmonary disease. , 2016, The Lancet. Respiratory medicine.

[313]  Thomas R Fanshawe,et al.  Combined pharmacotherapy and behavioural interventions for smoking cessation. , 2016, The Cochrane database of systematic reviews.

[314]  E. A. V. van Eerd,et al.  Smoking cessation for people with chronic obstructive pulmonary disease. , 2016, The Cochrane database of systematic reviews.

[315]  Hakan Günen,et al.  Waterpipe tobacco smoking. , 2016, Tuberkuloz ve toraks.

[316]  F. Martinez,et al.  Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial , 2016, The Lancet.

[317]  G. Michaud,et al.  Effect of Endobronchial Coils vs Usual Care on Exercise Tolerance in Patients With Severe Emphysema: The RENEW Randomized Clinical Trial. , 2016, JAMA.

[318]  J. Wedzicha,et al.  Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD. , 2016, The New England journal of medicine.

[319]  Robert Paine,et al.  Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function. , 2016, The New England journal of medicine.

[320]  A. Schols,et al.  The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review , 2016, COPD.

[321]  T. Troosters,et al.  Increasing implementation and delivery of pulmonary rehabilitation: key messages from the new ATS/ERS policy statement , 2016, European Respiratory Journal.

[322]  David M. Shade,et al.  A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. , 2016, The New England journal of medicine.

[323]  M. V. Lopez Varela,et al.  Development of a simple screening tool for opportunistic COPD case finding in primary care in Latin America: The PUMA study , 2016, Respirology.

[324]  Anne Holland,et al.  Pulmonary Rehabilitation Exercise Prescription in Chronic Obstructive Pulmonary Disease: Review of Selected Guidelines: AN OFFICIAL STATEMENT FROM THE AMERICAN ASSOCIATION OF CARDIOVASCULAR AND PULMONARY REHABILITATION. , 2016, Journal of cardiopulmonary rehabilitation and prevention.

[325]  Dave Singh,et al.  Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial , 2016, The Lancet.

[326]  J. Wedzicha,et al.  Beta-blockers in COPD: time for reappraisal , 2016, European Respiratory Journal.

[327]  R. Rodríguez-Roisín,et al.  Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial. , 2016, Chest.

[328]  Y. Kuo,et al.  Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD. , 2016, Chest.

[329]  Michel Wolff,et al.  Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. , 2017, The Cochrane database of systematic reviews.

[330]  S. Ginsburg,et al.  Bronchodilator Delivery in Acute Airflow Obstruction , 2017 .

[331]  P. Poole,et al.  Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. , 2017, The Cochrane database of systematic reviews.

[332]  N. Team.  Chronic obstructive pulmonary disease in over 16s: diagnosis and management , 2018 .

[333]  P. Poole,et al.  Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. , 2019, The Cochrane database of systematic reviews.