Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine–clonidine mixture when administered as a caudal or ilioinguinal–iliohypogastric nerve blockade for inguinal surgery in children

Summary Background: The adjunctive use of clonidine to local anaesthetics has been reported to enhance analgesia both after spinal and peripheral administration. However, no attempt has been made to compare spinal and peripheral application of clonidine in the same surgical context in order to further explore the mechanism for the analgesic action of clonidine when administered together with local anaesthetics.

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