Analysis of chromosome genomic signals

The paper gives results in the analysis of genomic signals at the scale of whole chromosomes. For illustration purposes, eukaryote chromosomes are presented, but the same methods have been applied for the analysis of prokaryote chromosomes. Phase analysis, 2D (complex) and 3D (vector) sequence path analysis, and statistical analysis are presented. Based on the comparative behaviour of the cumulated and the unwrapped phases, a model of the structure of chromosomes is inferred.

[1]  Paul Dan Cristea.  Large-scale and global features of complex genomic signals , 2003, Saratov Fall Meeting.

[2]  Temple F. Smith,et al.  Patterns of Genome Organization in Bacteria , 1998, Science.

[3]  N. W. Davis,et al.  The complete genome sequence of Escherichia coli K-12. , 1997, Science.

[4]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[5]  P D Cristea.  Conversion of nucleotides sequences into genomic signals , 2002, Journal of cellular and molecular medicine.

[6]  Paul Dan Cristea.  Genetic signal analysis , 2001, Proceedings of the Sixth International Symposium on Signal Processing and its Applications (Cat.No.01EX467).

[7]  A Grigoriev,et al.  Analyzing genomes with cumulative skew diagrams. , 1998, Nucleic acids research.

[8]  E. Chargaff.  Structure and function of nucleic acids as cell constituents. , 1951, Federation proceedings.

[9]  J. Lobry,et al.  A simple vectorial representation of DNA sequences for the detection of replication origins in bacteria. , 1996, Biochimie.

[10]  D. Forsdyke.  Sense in antisense? , 1995, Journal of Molecular Evolution.

[11]  C. Peng,et al.  Long-range correlations in nucleotide sequences , 1992, Nature.

[12]  Wentian Li,et al.  The Study of Correlation Structures of DNA Sequences: A Critical Review , 1997, Comput. Chem..

[13]  Timothy B. Stockwell,et al.  The Sequence of the Human Genome , 2001, Science.

[14]  Paul Dan Cristea,et al.  Large scale features in DNA genomic signals , 2003, Signal Process..

[15]  Paul Dan Cristea,et al.  Genetic signal representation and analysis , 2002, SPIE BiOS.