VEGF Induces Tie 2 Shedding via a Phosphoinositide 3-Kinase / Akt – Dependent Pathway to Modulate Tie 2 Signaling

Original received June 26, 2007; final version accepted September 17, 2007. From the Department of Pharmacology and Cancer Biology (C.M.F., C.D.K.), Duke University Medical Center and the Duke University School of Medicine (C.M.F.), Durham, NC; the Department of Medicine (C.M.F., C.D.K.), Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC; and the Department of Reproductive and Vascular Biology (M.J.C., A.A.), Institute for Biomedical Research, The Medical School, University of Birmingham, UK. This work was presented in part at the 7th Annual Scientific Sessions of the Council on Arteriosclerosis, Thrombosis, and Vascular Biology in Denver, Co, April 2006. Correspondence to Christopher D. Kontos, Box 3629 DUMC, Durham, NC 27710. E-mail cdkontos@duke.edu © 2007 American Heart Association, Inc.

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