Poly(vinyl chloride) and Poly(e-caprolactone) Blends for Medical Use

This study examines the possibility of replacing partially or totally the di(2-ethylhexyl) phthalate (DEHP - low molecular plasticizer) from the poly(vinyl chloride) (PVC) compositions intended for medical devices, with poly("-caprolactone) (PCL - biodegradable, biocompatible, and macromolecular plasticizer). Nine different plasticized PVC (PVC-P) compositions are analyzed from the viewpoint of thermal and mechanical properties, plasticizer loss, and extraction behavior in different medical media. After comparing the experimental results with the data from the literature, corresponding to traditional PVC-P, it can be concluded that the PCL and even PCL-DEHP mixture behave as better plasticizers for PVC, providing a lower extraction risk and similar or even improved thermal and mechanical properties.

[1]  R. Rubin,et al.  Fate in Humans of the Plasticizer, Di‐2‐Ethylhexyl Phthalate, Arising from Transfusion of Platelets Stored in Vinyl Plastic Bags , 2003, Transfusion.

[2]  B. Lake,et al.  A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. , 1999, Regulatory toxicology and pharmacology : RTP.

[3]  M. Luyckx,et al.  Exposure of hemodialysis patients to di-2-ethylhexyl phthalate. , 1999, International journal of pharmaceutics.

[4]  K. Deepadevi,et al.  Decrease in the Concentration of Vitamin E in Blood and Tissues Caused by Di(2‐Ethylhexyl) Phthalate, a Commonly Used Plasticizer in Blood Storage Bags and Medical Tubing , 1998, Vox sanguinis.

[5]  S. Lakshmi,et al.  Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications. , 1998, Artificial organs.

[6]  R. Dickenson.  Di(2-ethylhexyl)phthalate as a plasticizer for intravenoous bags and tubing: A toxicological quandary , 1997 .

[7]  R. Rubin,et al.  Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate. , 1997, Critical care medicine.

[8]  G. Bauer.  What price progress? Failed innovations of the knee prosthesis. , 1992, Acta orthopaedica Scandinavica.

[9]  A. Bast,et al.  Plasticisers and bronchial hyperreactivity , 1990, The Lancet.

[10]  R. Rubin,et al.  What price progress?: An update on vinyl plastic blood bags , 1989 .

[11]  W. Keon,et al.  Cardiotoxic effects of the plasticizer metabolite, mono (2-ethylhexyl)phthalate (MEHP), on human myocardium. , 1988, Blood.

[12]  L. A. Dostal,et al.  Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. , 1988, Toxicology and applied pharmacology.

[13]  M. Roberts,et al.  Interactions between drugs and polyvinyl chloride infusion bags. , 1981, American journal of hospital pharmacy.

[14]  R. Rubin,et al.  Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues. , 1972, The New England journal of medicine.

[15]  R. D. Lundberg,et al.  Lactone polymers. I. Glass transition temperature of poly‐ε‐caprolactone by means on compatible polymer mixtures , 1969 .

[16]  A. Coaker.  POLY(VINYL CHLORIDE) , 2000 .

[17]  G. Eastmond.  Poly(ε-caprolactone) Blends , 2000 .

[18]  R. Dickerson.  Di(2-ethylhexyl)phthalate as a plasticizer for intravenous bags and tubing: a toxicological quandary. , 1997, Nutrition.

[19]  C. R. Blass,et al.  Poly(vinyl chloride) formulations: acute toxicity to cultured human cell lines. , 1995, Journal of biomaterials science. Polymer edition.

[20]  P. Borm,et al.  Plasticisers, another burden for asthmatics? , 1990, Agents and actions. Supplements.

[21]  R. Rubin,et al.  What price progress? An update on vinyl plastic bags. , 1989, Transfusion.

[22]  D. Stennett,et al.  Extraction of diethylhexylphthalate from total nutrient solution-containing polyvinyl chloride bags. , 1989, JPEN. Journal of parenteral and enteral nutrition.

[23]  L. Nässberger,et al.  Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. , 1987, Nephron.

[24]  M. Shaw,et al.  Polymer-Polymer Miscibility , 1979 .

[25]  C. F. Hammer.  Chapter 17 – Polymeric Plasticizers , 1978 .