Telaprevir-induced acute kidney injury during treatment of chronic hepatitis C.

The presence of Hp-I with accompanying immunohistochemical expression of CD44 [an indicator of cancer stem cells and/or bone marrow-derived stem cells (BMDSCs)] in biopsy specimens was found in a high proportion of CRA patients with moderate/severe dysplasia (88%) and in CRC patients with a moderate/severe degree of malignancy (91%) [2,3]. Comparable results were also obtained for proliferation marker Ki-67, antiapoptotic Bcl-2, and CD45 (assessing mainly T and B lymphocytes locally) immunohistochemical expressions [2,3].