Continuous bioprocessing: The real thing this time?

The Annual bioProcessUK Conference has acted as the key networking event for bioprocess scientists and engineers in the UK for the past 10 years. The following article is a report from the sessions that focused on continuous bioprocessing during the 10th Annual bioProcessUK Conference (London, December 2013). These sessions were organized by the ‘EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies’ hosted at University College London. A plenary lecture and workshop provided a forum for participants to debate topical issues in roundtable discussions with industry and academic experts from institutions such as Genzyme, Janssen, Novo Nordisk, Pfizer, Merck, GE Healthcare and University College London. The aim of these particular sessions was to understand better the challenges and opportunities for continuous bioprocessing in the bioprocessing sector.

[1]  Daniel G Bracewell,et al.  Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture. , 2013, Journal of chromatography. A.

[2]  Ekta Mahajan,et al.  Improving affinity chromatography resin efficiency using semi-continuous chromatography. , 2012, Journal of chromatography. A.

[3]  Marc Bisschops,et al.  The impact of continuous multicolumn chromatography on biomanufacturing efficiency , 2013 .

[4]  Frank Riske,et al.  Periodic counter-current chromatography -- design and operational considerations for integrated and continuous purification of proteins. , 2012, Biotechnology journal.

[5]  Konstantin B Konstantinov,et al.  White paper on continuous bioprocessing. May 20-21, 2014 Continuous Manufacturing Symposium. , 2015, Journal of pharmaceutical sciences.

[6]  Daniel Cummings,et al.  Integrated continuous production of recombinant therapeutic proteins , 2012, Biotechnology and bioengineering.

[7]  Marcella Yu,et al.  Effects of cell culture conditions on antibody N‐linked glycosylation—what affects high mannose 5 glycoform , 2011, Biotechnology and bioengineering.

[8]  H Baldascini,et al.  Rapid whole monoclonal antibody analysis by mass spectrometry: An Ultra scale‐down study of the effect of harvesting by centrifugation on the post‐translational modification profile , 2010, Biotechnology and bioengineering.

[9]  Suzanne S. Farid,et al.  Evaluating the economic and operational feasibility of continuous processes for monoclonal antibodies , 2014 .

[10]  Suzanne S Farid,et al.  Fed‐batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty , 2013, Biotechnology and bioengineering.

[11]  Brian Kelley,et al.  Industrialization of mAb production technology: The bioprocessing industry at a crossroads , 2009, mAbs.

[12]  Charles L. Cooney,et al.  White Paper on Continuous Bioprocessing , 2014 .