Drug resistant malaria on the Thai-Myanmar and Thai-Cambodian borders.

We describe the changing epidemiology of drug resistant malaria in Thailand over the past decade. Factors determining the characteristic patterns of the development and spread of resistance to anti-malarial drugs on the Thai-Cambodian border and the Thai-Myanmar border are explored, namely, population dynamics, drug usage and malaria control measures. The introduction of artesunate-mefloquine combination in selected areas along the two borders in 1995 is believed to be one of the multiple factors responsible for stabilizing the multidrug resistance problems in Thailand today. Other control measures and inter-governmental co-operation must continue to be strengthened in order to limit the spread of drug resistance malaria in the Southeast Asian region.

[1]  K. Kirk,et al.  Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum , 2000, Nature.

[2]  K. Bojang,et al.  Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial , 2000, The Lancet.

[3]  C. Rogier,et al.  In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs. , 1998, The American journal of tropical medicine and hygiene.

[4]  S. Meshnick.  Artemisinin antimalarials: mechanisms of action and resistance. , 1998, Medecine tropicale : revue du Corps de sante colonial.

[5]  J. Le bras.  In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu. , 1998, Medecine tropicale : revue du Corps de sante colonial.

[6]  A. Michault,et al.  [Serologic studies of non-venereal treponematoses in infants in Niamey, Niger]. , 1998, Medecine tropicale : revue du Corps de sante colonial.

[7]  D. Kyle,et al.  Pharmacokinetics and pharmacodynamics of qinghaosu derivatives: how do they impact on the choice of drug and the dosage regimens? , 1998, Medecine tropicale : revue du Corps de sante colonial.

[8]  P. Rathod,et al.  Variations in frequencies of drug resistance in Plasmodium falciparum. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Price,et al.  Effects of artemisinin derivatives on malaria transmissibility , 1996, The Lancet.

[10]  K. Thimasarn,et al.  In vivo study of the response of Plasmodium falciparum to standard mefloquine/sulfadoxine/pyrimethamine (MSP) treatment among gem miners returning from Cambodia. , 1995, The Southeast Asian journal of tropical medicine and public health.

[11]  G. Shanks.  1993 Sir Henry Wellcome Medal and Prize recipient. The rise and fall of mefloquine as an antimalarial drug in South East Asia. , 1994, Military medicine.

[12]  W. Wernsdorfer.  Epidemiology of drug resistance in malaria. , 1994, Acta tropica.

[13]  W. Wernsdorfer,et al.  A symposium on containment of mefloquine-resistant falciparum malaria in Southeast Asia with special reference to border malaria. , 1994, The Southeast Asian journal of tropical medicine and public health.

[14]  F. Gay,et al.  In-vitro tests on Philippine isolates of Plasmodium falciparum against four standard antimalarials and four qinghaosu derivatives. , 1994, Bulletin of the World Health Organization.

[15]  A. Walker,et al.  Predictors of treatment failure in multiple drug-resistant falciparum malaria: results from a 42-day follow-up of 224 patients in eastern Thailand. , 1993, The American journal of tropical medicine and hygiene.

[16]  J. Le bras,et al.  In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum. , 1993, The American journal of tropical medicine and hygiene.

[17]  M. Halloran,et al.  Malaria: living with drug resistance. , 1993, Parasitology today.

[18]  H. Webster,et al.  Emergence of multidrug-resistant Plasmodium falciparum in Thailand: in vitro tracking. , 1992, The American journal of tropical medicine and hygiene.

[19]  K. Thimasarn,et al.  Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand. , 1992, The Southeast Asian journal of tropical medicine and public health.

[20]  W. Wernsdorfer,et al.  The development and spread of drug-resistant malaria. , 1991, Parasitology today.

[21]  H. Webster,et al.  Mefloquine-resistant falciparum malaria on the Thai-Burmese border , 1991, The Lancet.

[22]  K. Thimasarn,et al.  Phase III double-blind comparative study of Fansimef and Lariam for the curative treatment of Plasmodium falciparum infections in Thailand. , 1990, The Southeast Asian journal of tropical medicine and public health.

[23]  H. Webster,et al.  Two cases of mefloquine resistant malaria in Thailand. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[24]  W. Wernsdorfer,et al.  Sensitivity to quinine and mefloquine of Plasmodium falciparum in Thailand. , 1986, Bulletin of the World Health Organization.

[25]  H. Webster,et al.  Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method. , 1985, The American journal of tropical medicine and hygiene.

[26]  H. Webster,et al.  TYPE II MEFLOQUINE RESISTANCE IN THAILAND , 1982, The Lancet.

[27]  K. Thimasarn,et al.  An evaluation of five regimens for the outpatient therapy of falciparum malaria in Thailand 1980-81. , 1982, Bulletin of the World Health Organization.

[28]  T. Harinasuta,et al.  Sulphormethoxine in chloroquine-resistant falciparum malaria in Thailand. , 1967, Lancet.

[29]  T. Harinasuta,et al.  Chloroquine-resistant falciparum malaria in Thailand. , 1965, Lancet.

[30]  G. Saunders.  The treatment of malaria. , 1947, Missouri medicine.