Radiofrequency-induced hyperthermia: computer simulation of specific absorption rate distributions using realistic anatomical models.

A description is given of a computer simulation technique which predicts the specific absorption rate (SAR) distribution within the human body resulting from the application of radiofrequency electromagnetic energy. The method uses an extension to the principle of over-relaxation of electric potentials and the basis of the simulation is a realistic three-dimensional model derived from both dielectric and anatomical data. Two of the principal means of applying radiofrequency hyperthermia, namely the use of capacitive electrodes and inductive coils, have been provided for. The accuracy of the simulation has been favourably tested using an agar split-phantom and an infrared thermograph camera. The simulations can be used to assist the design and clinical use of radiofrequency applicators, and examples are given of the application of both an inductive coil and switched capacitive electrodes to heat the thorax.

[1]  J. Lagendijk The influence of bloodflow in large vessels on the temperature distribution in hyperthermia. , 1982, Physics in medicine and biology.

[2]  D. Waggott,et al.  Tumor eradication in the rabbit by radiofrequency heating. , 1977, Cancer research.

[3]  J. Hand Microwave heating patterns in simple tissue models. , 1977, Physics in medicine and biology.

[4]  D L Morton,et al.  Human hyperthermic therapy: relation between tumor type and capacity to induce hyperthermia by radiofrequency. , 1979, American journal of surgery.

[5]  Ivan A. Brezovich,et al.  Frequency/depth-penetration considerations in hyperthermia by magnetically induced currents , 1980 .

[6]  Ronald Pethig,et al.  Dielectric and electronic properties of biological materials , 1979 .

[7]  N T Evans,et al.  Considerations of radiofrequency induction heating for localised hyperthermia. , 1982, Physics in medicine and biology.

[8]  J. Kim,et al.  Selective Heating of Cutaneous Human Tumors at 27.12 MHz , 1978 .

[9]  Ernst Weber,et al.  Electromagnetic fields , 1950 .

[10]  D L Morton,et al.  Hyperthermic therapy for human neoplasms: Thermal death time , 1980, Cancer.

[11]  J. Hand,et al.  Heating techniques in hyperthermia , 1981 .

[12]  D. Young Iterative methods for solving partial difference equations of elliptic type , 1954 .

[13]  Arthur W. Guy,et al.  Therapeutic applications of electromagnetic power , 1974 .

[14]  E. Gerner,et al.  Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man. , 1977, Radiology.

[15]  N. Bleehen,et al.  Hyperthermia in the treatment of cancer. , 1982, The British journal of cancer. Supplement.

[16]  J. Patterson,et al.  The role of blood flow in hyperthermia. , 1979, International journal of radiation oncology, biology, physics.

[17]  C. Weil,et al.  Absorption Characteristics of Multilayered Sphere Models Exposed to UHF/Microwave Radiation , 1975, IEEE Transactions on Biomedical Engineering.

[18]  A. W. Guy,et al.  Analyses of Electromagnetic Fields Induced in Biological Tissues by Thermographic Studies on Equivalent Phantom Models , 1971 .

[19]  H H LeVeen,et al.  A histopathologic study on the effects of radiofrequency thermotherapy on malignant tumors of the lung , 1979, Cancer.

[20]  G. Hahn,et al.  Tumor cure and cell survival after localized radiofrequency heating. , 1977, Cancer research.

[21]  J. Overgaard,et al.  Investigations on the possibility of a thermic tumour therapy. I. Short-wave treatment of a transplanted isologous mouse mammary carcinoma. , 1972, European journal of cancer.