Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus

[1]  W. Wong,et al.  A2E accumulation influences retinal microglial activation and complement regulation , 2013, Neurobiology of Aging.

[2]  Tobias Jung,et al.  Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. , 2012, Free radical biology & medicine.

[3]  O. Albayram,et al.  Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory , 2012, Front. Ag. Neurosci..

[4]  Alonso Emilio,et al.  β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment , 2012, EMBO molecular medicine.

[5]  W. Maier,et al.  Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1−/− mice , 2012, Neurobiology of Aging.

[6]  K. Sandhoff,et al.  Mass spectrometric analysis of neutral sphingolipids: methods, applications, and limitations. , 2011, Biochimica et biophysica acta.

[7]  Tudor I. Oprea,et al.  Intracellular Cannabinoid Type 1 (CB1) Receptors Are Activated by Anandamide* , 2011, The Journal of Biological Chemistry.

[8]  Beat Lutz,et al.  Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging , 2011, Proceedings of the National Academy of Sciences.

[9]  J. P. Andrade,et al.  Chronic green tea consumption prevents age-related changes in rat hippocampal formation , 2011, Neurobiology of Aging.

[10]  M. Marra,et al.  Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism , 2011, Cell Death and Disease.

[11]  C. Dray,et al.  Cathepsin-D, a Key Protease in Breast Cancer, Is Up-Regulated in Obese Mouse and Human Adipose Tissue, and Controls Adipogenesis , 2011, PloS one.

[12]  Steven Finkbeiner,et al.  A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model , 2010, Proceedings of the National Academy of Sciences.

[13]  Tobias Jung,et al.  Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells. , 2010, Free radical biology & medicine.

[14]  B. Yankner,et al.  Neural mechanisms of ageing and cognitive decline , 2010, Nature.

[15]  N. Mizushima,et al.  Methods in Mammalian Autophagy Research , 2010, Cell.

[16]  S. Qian,et al.  Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: Correlations with behavior and oxidative stress , 2009, Neurochemistry International.

[17]  R. Neubert,et al.  Normal phase liquid chromatography coupled to quadrupole time of flight atmospheric pressure chemical ionization mass spectrometry for separation, detection and mass spectrometric profiling of neutral sphingolipids and cholesterol. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[18]  R. Maldonado,et al.  Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling , 2009, Nature Neuroscience.

[19]  U. Brunk,et al.  Oxidized proteins: Mechanisms of removal and consequences of accumulation , 2009, IUBMB life.

[20]  P. Pandolfi,et al.  Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. , 2009, The Journal of clinical investigation.

[21]  Ralph A. Nixon,et al.  Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease , 2008, The Journal of Neuroscience.

[22]  L. Devi,et al.  Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP‐3 , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  A. Gowran,et al.  A role for p53 in the regulation of lysosomal permeability by Δ9‐tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration , 2008, Journal of neurochemistry.

[24]  T. Kurz.  Can lipofuscin accumulation be prevented? , 2008, Rejuvenation research.

[25]  T. Gotow,et al.  Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice , 2008, Neuroscience.

[26]  R. Kesner.  Behavioral functions of the CA3 subregion of the hippocampus. , 2007, Learning & memory.

[27]  H. Nakanishi,et al.  Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice , 2007, Molecular and Cellular Neuroscience.

[28]  F. Dela,et al.  Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle , 2007, Aging cell.

[29]  P. Saftig,et al.  Altered Regulation of Phosphatidylinositol 3-kinase Signaling in Cathepsin D-Deficient Brain , 2007, Autophagy.

[30]  M. MacDonald,et al.  Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis* , 2006, Journal of Biological Chemistry.

[31]  O. Valverde,et al.  Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[32]  G. Velasco,et al.  Cannabinoids and ceramide: two lipids acting hand-by-hand. , 2005, Life sciences.

[33]  K. Jin,et al.  Involvement of Protein Kinase A in Cannabinoid Receptor-Mediated Protection from Oxidative Neuronal Injury , 2005, Journal of Pharmacology and Experimental Therapeutics.

[34]  L. Petrocellis,et al.  The endocannabinoid system and its therapeutic exploitation , 2004, Nature Reviews Drug Discovery.

[35]  H. Nakanishi.  Neuronal and microglial cathepsins in aging and age-related diseases , 2003, Ageing Research Reviews.

[36]  Federico V Pallardó,et al.  The role of mitochondrial oxidative stress in aging. , 2003, Free radical biology & medicine.

[37]  Siegfried Hekimi,et al.  Genetics and the Specificity of the Aging Process , 2003, Science.

[38]  S. Melov,et al.  Oxidative stress and aging: beyond correlation , 2002, Aging cell.

[39]  Hidde L. Ploegh,et al.  Neuronal loss and brain atrophy in mice lacking cathepsins B and L , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Levine.  Carbonyl modified proteins in cellular regulation, aging, and disease. , 2002, Free radical biology & medicine.

[41]  U. Brunk,et al.  The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. , 2002, European journal of biochemistry.

[42]  小池 正人.  Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons , 2002 .

[43]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[44]  H. Nakanishi,et al.  Involvement of Nitric Oxide Released from Microglia–Macrophages in Pathological Changes of Cathepsin D-Deficient Mice , 2001, The Journal of Neuroscience.

[45]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[46]  W. Schneider-Brachert,et al.  Cathepsin D targeted by acid sphingomyelinase‐derived ceramide , 1999, The EMBO journal.

[47]  H. Nakanishi,et al.  Increased Expression of Cathepsins E and D in Neurons of the Aged Rat Brain and Their Colocalization with Lipofuscin and Carboxy‐Terminal Fragments of Alzheimer Amyloid Precursor Protein , 1997, Journal of neurochemistry.

[48]  R. S. Sohal,et al.  Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. , 1996, Archives of biochemistry and biophysics.

[49]  M. Baudry,et al.  Oxygen free radicals in rat limbic structures after kainate-induced seizures. , 1995, Free radical biology & medicine.

[50]  M. Silbermann,et al.  Age-related structural changes in the rat hippocampus: correlation with working memory deficiency , 1990, Brain Research.

[51]  D. Harman.  Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[52]  B. Kamińska,et al.  Cannabinoid signaling in glioma cells. , 2013, Advances in experimental medicine and biology.

[53]  G. Velasco,et al.  Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy , 2011, Cell Death and Differentiation.

[54]  M. Abood.  Molecular biology of cannabinoid receptors. , 2005, Handbook of experimental pharmacology.

[55]  H. Nakanishi,et al.  Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. , 2000, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[56]  L. Packer,et al.  Oxidative damage to proteins: spectrophotometric method for carbonyl assay. , 1994, Methods in enzymology.

[57]  E. Stadtman,et al.  Carbonyl assays for determination of oxidatively modified proteins. , 1994, Methods in enzymology.