Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

Host resistance to Mycobacterium tuberculosis infection is mediated through cellular type I immunity. Bohrer et al. reveal an unexpected association between type II immunity-related eosinophils and TB in humans, nonhuman primates, and mice, where eosinophil deficiency results in increased disease susceptibility.

[1]  S. Gregory,et al.  A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization , 2021, Cell.

[2]  A. Sher,et al.  Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis , 2020, Mucosal Immunology.

[3]  C. Sassetti,et al.  CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis , 2020, PLoS pathogens.

[4]  K. McCoy,et al.  The emerging roles of eosinophils in mucosal homeostasis , 2020, Mucosal Immunology.

[5]  M. Shiloh,et al.  Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough , 2020, Cell.

[6]  S. Ackerman,et al.  Contributions of Eosinophils to Human Health and Disease. , 2020, Annual review of pathology.

[7]  J. Grenier,et al.  Dual RNA-Seq of Mtb-Infected Macrophages In Vivo Reveals Ontologically Distinct Host-Pathogen Interactions , 2020, Cell reports.

[8]  T. E. Bozkurt.  Endocannabinoid System in the Airways , 2019, Molecules.

[9]  H. Rosenberg,et al.  The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020 , 2019, International Archives of Allergy and Immunology.

[10]  L. Via,et al.  Changes in inflammatory protein and lipid mediator profiles persist after antitubercular treatment of pulmonary and extrapulmonary tuberculosis: A prospective cohort study. , 2019, Cytokine.

[11]  E. Gold,et al.  Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo , 2019, Science Immunology.

[12]  Jing-Wen Lin,et al.  Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases , 2019, Nature Communications.

[13]  J. Greenberg,et al.  Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils. , 2019, JCI insight.

[14]  N. Beeching,et al.  Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection , 2018, Front. Immunol..

[15]  T. Myers,et al.  Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression , 2018, Nature Microbiology.

[16]  A. Fryer,et al.  Eosinophils increase airway sensory nerve density in mice and in human asthma , 2018, Science Translational Medicine.

[17]  Michael Y. Gerner,et al.  Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination. , 2018, Cell host & microbe.

[18]  H. Veiga-Fernandes,et al.  Neuro-immune regulation of mucosal physiology , 2018, Mucosal Immunology.

[19]  A. Casrouge,et al.  Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions , 2018, Front. Immunol..

[20]  M. van den Broek,et al.  Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation , 2018, The Journal of experimental medicine.

[21]  A. Fryer,et al.  Eosinophil and airway nerve interactions in asthma , 2018, Journal of leukocyte biology.

[22]  V. Mizrahi,et al.  Mycobacterium tuberculosis. , 2018, Trends in microbiology.

[23]  D. Russell,et al.  Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny , 2018, The Journal of experimental medicine.

[24]  R. Hunter,et al.  Pathology of Tuberculosis: How the Pathology of Human Tuberculosis Informs and Directs Animal Models. , 2017, Microbiology spectrum.

[25]  Gang Sun,et al.  The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy , 2017, Genome Biology.

[26]  T. Nutman,et al.  Helminth-Tuberculosis Co-infection: An Immunologic Perspective. , 2016, Trends in immunology.

[27]  H. Veiga-Fernandes,et al.  Neuro-Immune Interactions at Barrier Surfaces , 2016, Cell.

[28]  M. Robinson,et al.  Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences , 2015, F1000Research.

[29]  Guangchuang Yu,et al.  ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. , 2016, Molecular bioSystems.

[30]  M. Robinson,et al.  Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. , 2015, F1000Research.

[31]  A. Aseffa,et al.  Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity , 2015, PLoS neglected tropical diseases.

[32]  M. Rothenberg,et al.  Eosinophils in mucosal immune responses , 2015, Mucosal Immunology.

[33]  J. Flynn,et al.  Immunology studies in non‐human primate models of tuberculosis , 2015, Immunological reviews.

[34]  A. Sher,et al.  Cytokine and lipid mediator networks in tuberculosis , 2015, Immunological reviews.

[35]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[36]  A. Sher,et al.  Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk , 2014, Nature.

[37]  K. Acharya,et al.  Eosinophil Granule Proteins: Form and Function , 2014, The Journal of Biological Chemistry.

[38]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[39]  D. Barber,et al.  Intravascular staining for discrimination of vascular and tissue leukocytes , 2014, Nature Protocols.

[40]  C. Steele,et al.  Eosinophil Deficiency Compromises Lung Defense against Aspergillus fumigatus , 2013, Infection and Immunity.

[41]  R. Wilkinson,et al.  Neutrophilia independently predicts death in tuberculosis , 2013, European Respiratory Journal.

[42]  L. Ramakrishnan,et al.  Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish , 2013, Nature Protocols.

[43]  Robert J Wilkinson,et al.  The immune response in tuberculosis. , 2013, Annual review of immunology.

[44]  K. Dyer,et al.  Eosinophils: changing perspectives in health and disease , 2012, Nature Reviews Immunology.

[45]  M. Jacobsen,et al.  Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based study , 2012, BMC Infectious Diseases.

[46]  M. Rämet,et al.  Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish , 2012, PLoS pathogens.

[47]  Ian D Pavord,et al.  Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial , 2012, The Lancet.

[48]  J. Ernst.  The immunological life cycle of tuberculosis , 2012, Nature Reviews Immunology.

[49]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[50]  J. Ellner,et al.  ‘Coinfection-helminthes and tuberculosis’ , 2012, Current opinion in HIV and AIDS.

[51]  K. Iwai.  [Pathology of tuberculosis]. , 2011, Kekkaku : [Tuberculosis].

[52]  James J. Lee,et al.  Eosinophils in health and disease: the LIAR hypothesis , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[53]  C. Beglinger,et al.  Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial , 2009, Gut.

[54]  James J. Lee,et al.  Mouse Eosinophils Possess Potent Antibacterial Properties In Vivo , 2009, Infection and Immunity.

[55]  A. Straumann,et al.  Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense , 2008, Nature Medicine.

[56]  J. Parkin,et al.  Treatment of patients with the hypereosinophilic syndrome with mepolizumab. , 2008, The New England journal of medicine.

[57]  S. Phipps,et al.  Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. , 2007, Blood.

[58]  J. Ernst,et al.  Mycobacterium tuberculosis Infects Dendritic Cells with High Frequency and Impairs Their Function In Vivo1 , 2007, The Journal of Immunology.

[59]  D. Born,et al.  Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity , 2006, Infection and Immunity.

[60]  E. Lenkiewicz,et al.  Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils , 2004, Science.

[61]  I. Orme,et al.  Rapid Accumulation of Eosinophils in Lung Lesions in Guinea Pigs Infected with Mycobacterium tuberculosis , 2004, Infection and Immunity.

[62]  E. Banfi,et al.  Human Eosinophil Peroxidase Induces Surface Alteration, Killing, and Lysis of Mycobacterium tuberculosis , 2003, Infection and Immunity.

[63]  S. Orkin,et al.  Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo , 2002, The Journal of experimental medicine.

[64]  M. Walsh,et al.  Adhesion-dependent interactions between eosinophils and cholinergic nerves. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[65]  J. Flynn,et al.  Immune responses in tuberculosis. , 2000, Current opinion in immunology.

[66]  B. Delahunt,et al.  Role of Eosinophils in the Pathogenesis ofMycobacterium bovis BCG Infection in Gamma Interferon Receptor-Deficient Mice , 2000, Infection and Immunity.

[67]  G. Gleich,et al.  Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. , 1997, The American journal of physiology.

[68]  I. Orme,et al.  Disseminated tuberculosis in interferon gamma gene-disrupted mice , 1993, The Journal of experimental medicine.

[69]  J. Flynn,et al.  An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection , 1993, The Journal of experimental medicine.

[70]  R. Prabhakar,et al.  Pulmonary eosinophilia in pulmonary tuberculosis. , 1992, Chest.

[71]  M. Wills-Karp,et al.  Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge. , 1991, Journal of applied physiology.

[72]  L. Gabbasova,et al.  Global tuberculosis report (2014) , 2014 .

[73]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[74]  L. Spencer,et al.  Eosinophils in innate immunity: an evolving story , 2010, Cell and Tissue Research.

[75]  T. Nutman,et al.  The role of eosinophils in host defense against helminth parasites. , 2004, The Journal of allergy and clinical immunology.