Effects of burns on inhalation injury.

BACKGROUND There are few studies of smoke injury combined with thermal burn. METHODS Seven sheep (G1) received smoke injury alone; eight (G2) received a 40% full-thickness scald burn immediately after smoke injury. All animals were resuscitated with lactated Ringer's solution and killed 48 hours after injury. Cardiopulmonary variables and blood gases were measured serially. Ventilation perfusion distribution was analyzed using the multiple inert gas elimination technique. Lung wet to dry weight ratio and malondialdehyde levels were determined. RESULTS G2 resulted in early significant hemodynamic changes. Serum total protein concentration was significantly lower and malondialdehyde significantly higher in G2. However, PaO2, lung wet to dry weight ratio, and ventilation perfusion mismatching in G2 did not differ from those in G1. CONCLUSIONS Although the addition of burn injury exaggerated the lung lipid peroxidation and hypoproteinemia in the presence of more pronounced hemodynamic changes, the pulmonary dysfunction was not accentuated.

[1]  Y. Youn,et al.  Effect of graded increases in smoke inhalation injury on the early systemic response to a body burn. , 1995, Critical care medicine.

[2]  A. Mason,et al.  The effect of inhaled nitric oxide on pulmonary ventilation-perfusion matching following smoke inhalation injury. , 1994, The Journal of trauma.

[3]  D. Herndon,et al.  The sequence of injury determines the degree of lung damage in both inhalation and thermal injuries. , 1994 .

[4]  R. Demling,et al.  Relationship of burn‐induced lung lipid peroxidation on the degree of injury after smoke inhalation and a body burn , 1993, Critical care medicine.

[5]  W. Cioffi,et al.  Leukocyte responses to injury. , 1993, Archives of surgery.

[6]  Y. Youn,et al.  Burn edema is accentuated by a moderate smoke inhalation injury in sheep. , 1992, Surgery.

[7]  William R. Jr. Clark.  Smoke inhalation: Diagnosis and treatment , 1992, World journal of surgery.

[8]  R. Rodríguez-Roisín,et al.  Clinical relevance of ventilation-perfusion inequality determined by inert gas elimination. , 1990, The European respiratory journal.

[9]  B. Halliwell,et al.  The measurement and mechanism of lipid peroxidation in biological systems. , 1990, Trends in biochemical sciences.

[10]  R. Barrow,et al.  Inhalation injury in burned patients: effects and treatment. , 1988, Burns, including thermal injury.

[11]  G. Kramer,et al.  Role of thermal injury-induced hypoproteinemia on fluid flux and protein permeability in burned and nonburned tissue. , 1984, Surgery.

[12]  F. Lewis,et al.  Effect of inhalation injury on lung water accumulation. , 1983, The Journal of trauma.

[13]  G. Kramer,et al.  Effect of hypoproteinemia on pulmonary and soft tissue edema formation , 1981, Critical care medicine.

[14]  F. Lewis,et al.  Lung Water Changes After Thermal Injury: The Effects of Crystalloid Resuscitation and Sepsis , 1980, Annals of surgery.

[15]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.