The role of nutrition in children's neurocognitive development, from pregnancy through childhood

This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.

[1]  T. Klingberg,et al.  Maturation of White Matter is Associated with the Development of Cognitive Functions during Childhood , 2004, Journal of Cognitive Neuroscience.

[2]  J. Bryan,et al.  Nutrients for cognitive development in school-aged children. , 2004, Nutrition reviews.

[3]  M. Blössner,et al.  Global prevalence and trends of overweight and obesity among preschool children. , 2010, The American journal of clinical nutrition.

[4]  D. Joshua,et al.  The impact of mandatory fortification of flour with folic acid on the blood folate levels of an Australian population , 2011, The Medical journal of Australia.

[5]  Sabine J. Roza,et al.  Breastfeeding and early brain development: the Generation R study. , 2013, Maternal & child nutrition.

[6]  S. Ramey,et al.  Folate Status of Mothers During Pregnancy and Mental and Psychomotor Development of Their Children at Five Years of Age , 2005, Pediatrics.

[7]  M. Georgieff,et al.  Iron deficiency and brain development. , 2006, Seminars in pediatric neurology.

[8]  G. Gutiérrez-Ospina,et al.  Prenatal protein malnutrition decreases mossy fibers-CA3 thorny excrescences asymmetrical synapses in adult rats , 2002, Brain Research.

[9]  Stephen R. Hooper,et al.  Research on the preschool prediction of later academic achievement: A review , 1988 .

[10]  F. Gomez-Pinilla,et al.  A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning , 2002, Neuroscience.

[11]  M. Asbridge,et al.  Diet quality and academic performance. , 2008, The Journal of school health.

[12]  The evidence linking zinc deficiency with children's cognitive and motor functioning. , 2003, The Journal of nutrition.

[13]  Kaustubh Supekar,et al.  Systems Neuroscience Review Article , 2011 .

[14]  B. Ames,et al.  Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. , 2005, The American journal of clinical nutrition.

[15]  T. Henriksen,et al.  The fetal origins hypothesis: placental insufficiency and inheritance versus maternal malnutrition in well‐nourished populations , 2002, Acta obstetricia et gynecologica Scandinavica.

[16]  A. Heath,et al.  Population groups at risk of zinc deficiency in Australia and New Zealand , 2011 .

[17]  B. Ames,et al.  An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring , 2006, Neuroscience & Biobehavioral Reviews.

[18]  C. Ani,et al.  Iron-Deficiency Anemia: Reexamining the Nature and Magnitude of the Public Health Problem A Review of Studies on the Effect of Iron Deficiency on Cognitive Development in Children , 2001 .

[19]  M. Zimmermann,et al.  Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. , 2006, The American journal of clinical nutrition.

[20]  S. Ramey,et al.  Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. , 2002, The Journal of pediatrics.

[21]  C. Petten Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis , 2004, Neuropsychologia.

[22]  Chittaranjan S. Yajnik,et al.  Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10- year-old children in South India. , 2010, The Journal of nutrition.

[23]  Terrill F. Saxon,et al.  Individual and developmental differences in disengagement of fixation in early infancy. , 1999, Child development.

[24]  F. Vigneau,et al.  Relationship between maternal DHA and iron status and infants' cognitive performance. , 2011, Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada.

[25]  Kristin Saarem,et al.  Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. , 2003, Pediatrics.

[26]  S. Blakemore,et al.  The role of puberty in the developing adolescent brain , 2010, Human brain mapping.

[27]  R. Gilbert,et al.  Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. , 2001, The Cochrane database of systematic reviews.

[28]  J. Reznick,et al.  Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers , 2009, Nutritional neuroscience.

[29]  S. El Arifeen,et al.  Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study. , 2008, The American journal of clinical nutrition.

[30]  J. Dowd,et al.  Childhood obesity and human capital accumulation. , 2012, Social science & medicine.

[31]  Alan Lucas,et al.  Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development , 2010, Pediatric Research.

[32]  C. Cooper,et al.  Dietary patterns in infancy and cognitive and neuropsychological function in childhood. , 2009, Journal of child psychology and psychiatry, and allied disciplines.

[33]  G. Delong,et al.  NEUROLOGICAL SIGNS IN CONGENITAL IODINE‐DEFICIENCY DISORDER (ENDEMIC CRETINISM) , 1985, Developmental medicine and child neurology.

[34]  M. Goldani,et al.  [Breastfeeding and cognitive development]. , 2003, Jornal de pediatria.

[35]  D. Gadian,et al.  The Effect of Early Human Diet on Caudate Volumes and IQ , 2008, Pediatric Research.

[36]  L. Benítez-Bribiesca,et al.  Dendritic Spine Pathology in Infants With Severe Protein-Calorie Malnutrition , 1999, Pediatrics.

[37]  M. R. Pepper,et al.  B12 in fetal development. , 2011, Seminars in cell & developmental biology.

[38]  C. Levenson Regulation of the NMDA receptor: implications for neuropsychological development. , 2006, Nutrition reviews.

[39]  John P. Allegrante,et al.  Health Behavior and Academic Achievement Among Adolescents: The Relative Contribution of Dietary Habits, Physical Activity, Body Mass Index, and Self-Esteem , 2010, Health education & behavior : the official publication of the Society for Public Health Education.

[40]  D. Forrest The developing brain and maternal thyroid hormone: finding the links. , 2004, Endocrinology.

[41]  Robert W Platt,et al.  Breastfeeding and child cognitive development: new evidence from a large randomized trial. , 2008, Archives of general psychiatry.

[42]  S Grantham-McGregor,et al.  A review of studies of the effect of severe malnutrition on mental development. , 1995, The Journal of nutrition.

[43]  Yuliya A. Evdokimova,et al.  Gestational hypothyroxinemia and cognitive function in offspring , 2006, Neuroscience and Behavioral Physiology.

[44]  K. Jones,et al.  Prenatal alcohol exposure patterns and alcohol-related birth defects and growth deficiencies: a prospective study. , 2012, Alcoholism, clinical and experimental research.

[45]  P. Coyle,et al.  Dietary zinc supplementation during pregnancy prevents spatial and object recognition memory impairments caused by early prenatal ethanol exposure , 2008, Behavioural Brain Research.

[46]  B. Koletzko LONG-CHAIN OMEGA 3 FATTY ACID SUPPLY IN PREGNANCY AND LACTATION , 2008 .

[47]  H. Sachdev,et al.  Zinc deficiency in pregnancy and fetal outcome. , 2006, Nutrition reviews.

[48]  J. Concato,et al.  How good is the evidence linking breastfeeding and intelligence? , 2002, Pediatrics.

[49]  P. Huttenlocher,et al.  Regional differences in synaptogenesis in human cerebral cortex , 1997, The Journal of comparative neurology.

[50]  F. Vijver,et al.  Signs of impaired cognitive function in adolescents with marginal cobalamin status. , 2000, The American journal of clinical nutrition.

[51]  Hein Putter,et al.  Persistent epigenetic differences associated with prenatal exposure to famine in humans , 2008, Proceedings of the National Academy of Sciences.

[52]  P. Glewwe,et al.  Developmental potential in the first 5 years for children in developing countries , 2007, The Lancet.

[53]  L. Dye,et al.  A systematic review of the effect of breakfast on the cognitive performance of children and adolescents , 2009, Nutrition Research Reviews.

[54]  A. Lichtenstein,et al.  Diet-induced obesity and spatial cognition in young male rats , 2008, Nutritional neuroscience.

[55]  M. Crespo,et al.  Psycho-intellectual Development of 3 Year-old Children with Early Gestational Iodine Deficiency , 2005 .

[56]  S. Innis,et al.  Dietary (n-3) fatty acids and brain development. , 2007, The Journal of nutrition.

[57]  K. Lillycrop,et al.  The Effect of Nutrition during Early Life on the Epigenetic Regulation of Transcription and Implications for Human Diseases , 2012, Lifestyle Genomics.

[58]  Jian Zhang,et al.  Overweight Is Associated With Decreased Cognitive Functioning Among School‐age Children and Adolescents , 2008, Obesity.

[59]  M. Zimmermann The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. , 2007, Thyroid : official journal of the American Thyroid Association.

[60]  B. Luna,et al.  White matter development in adolescence: a DTI study. , 2010, Cerebral cortex.

[61]  J. Sweeney,et al.  Studies of brain and cognitive maturation through childhood and adolescence: a strategy for testing neurodevelopmental hypotheses. , 2001, Schizophrenia bulletin.

[62]  E. Knudsen Sensitive Periods in the Development of the Brain and Behavior , 2004, Journal of Cognitive Neuroscience.

[63]  S. Zeisel Choline: critical role during fetal development and dietary requirements in adults. , 2006, Annual review of nutrition.

[64]  J. Troendle,et al.  Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. , 2008, The American journal of clinical nutrition.

[65]  B. Koletzko,et al.  Long-chain ω-3 fatty acid supply in pregnancy and lactation , 2008, Current opinion in clinical nutrition and metabolic care.

[66]  B. Kaplan,et al.  Does prenatal micronutrient supplementation improve children's mental development? A systematic review , 2011, BMC pregnancy and childbirth.

[67]  M. Alamy,et al.  Malnutrition and brain development: An analysis of the effects of inadequate diet during different stages of life in rat , 2012, Neuroscience & Biobehavioral Reviews.

[68]  L. Kooistra,et al.  Neonatal Effects of Maternal Hypothyroxinemia During Early Pregnancy , 2006, Pediatrics.

[69]  C. Nelson,et al.  Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. , 2011, The American journal of clinical nutrition.

[70]  C. Broadhurst,et al.  Rift Valley lake fish and shellfish provided brain-specific nutrition for early Homo , 1998, British Journal of Nutrition.

[71]  K. Dewey,et al.  Long-term consequences of stunting in early life. , 2011, Maternal & child nutrition.

[72]  James W. Anderson,et al.  Breast-feeding and cognitive development: a meta-analysis. , 1999, The American journal of clinical nutrition.

[73]  K. Northstone,et al.  Dietary patterns at 6, 15 and 24 months of age are associated with IQ at 8 years of age , 2012, European Journal of Epidemiology.

[74]  D. Bhat,et al.  Vitamin B12 Status of Pregnant Indian Women and Cognitive Function in their 9-year-old Children , 2008, Food and nutrition bulletin.

[75]  C. Eastman,et al.  Iodine deficiency in Australia: is iodine supplementation for pregnant and lactating women warranted? , 2010, The Medical journal of Australia.

[76]  S. Ramey,et al.  Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of age. , 2003, The American journal of clinical nutrition.

[77]  D. Benton The influence of dietary status on the cognitive performance of children. , 2010, Molecular nutrition & food research.

[78]  W. Meck,et al.  Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan , 2003, Neuroscience & Biobehavioral Reviews.

[79]  P. Berbel,et al.  Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. , 2009, Thyroid : official journal of the American Thyroid Association.

[80]  S. Taneja,et al.  Zinc and cognitive development , 2001, British Journal of Nutrition.

[81]  W. Fawzi,et al.  Effect of Maternal Multivitamin Supplementation on the Mental and Psychomotor Development of Children Who Are Born to HIV-1–Infected Mothers in Tanzania , 2006, Pediatrics.

[82]  U. Ramakrishnan,et al.  Role of docosahexaenoic acid in maternal and child mental health. , 2009, The American journal of clinical nutrition.

[83]  D. Kennedy,et al.  A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning , 2007, Appetite.

[84]  A. Toga,et al.  Mapping brain maturation , 2006, Trends in Neurosciences.

[85]  A. Gabory,et al.  Early nutrition and epigenetic programming: chasing shadows , 2010, Current opinion in clinical nutrition and metabolic care.

[86]  Satrajit S. Ghosh,et al.  Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11years of age , 2010, NeuroImage.

[87]  Catherine E. Ross,et al.  Refining the association between education and health: The effects of quantity, credential, and selectivity , 1999, Demography.

[88]  D. Benton Neurodevelopment and neurodegeneration: are there critical stages for nutritional intervention? , 2010, Nutrition reviews.

[89]  A. Simopoulos Evolutionary aspects of omega-3 fatty acids in the food supply. , 1999, Prostaglandins, leukotrienes, and essential fatty acids.

[90]  J. Jacobson,et al.  Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec. , 2008, The Journal of pediatrics.

[91]  Bruce N. Ames,et al.  Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals , 2005 .

[92]  B. Wandell,et al.  Children's Reading Performance is Correlated with White Matter Structure Measured by Diffusion Tensor Imaging , 2005, Cortex.

[93]  I. Egli,et al.  Iodine status worldwide: WHO Global Database on Iodine Deficiency , 2004 .

[94]  Jenny S. Radesky,et al.  Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. , 2008, American Journal of Epidemiology.

[95]  S. Taneja,et al.  Impact of zinc supplementation on mental and psychomotor scores of children aged 12 to 18 months: a randomized, double-blind trial. , 2005, The Journal of pediatrics.

[96]  S. Patole,et al.  Long-chain polyunsaturated fatty acid supplementation in preterm infants. , 2008, The Cochrane database of systematic reviews.

[97]  S. Prescott,et al.  Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial , 2006, Archives of Disease in Childhood Fetal and Neonatal Edition.

[98]  S. Cousens,et al.  Folic acid to reduce neonatal mortality from neural tube disorders , 2010, International journal of epidemiology.

[99]  J. Zhong,et al.  Developmental Iodine Deficiency and Hypothyroidism Impair Neural Development, Up‐Regulate Caveolin‐1 and Down‐Regulate Synaptophysin in Rat Hippocampus , 2010, Journal of neuroendocrinology.

[100]  A. Hahn,et al.  Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children , 2010, European Journal of Pediatrics.

[101]  P. Baghurst,et al.  Effect of iron supplementation during pregnancy on the intelligence quotient and behavior of children at 4 y of age: long-term follow-up of a randomized controlled trial. , 2006, The American journal of clinical nutrition.

[102]  G. Shaw,et al.  Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. , 2004, American journal of epidemiology.

[103]  Virginia B. Penhune,et al.  Sensitive periods in human development: Evidence from musical training , 2011, Cortex.

[104]  T. Wardlaw,et al.  Low birthweight: country regional and global estimates. , 2004 .

[105]  M. Nelson,et al.  Glycaemic index and glycaemic load of breakfast predict cognitive function and mood in school children: a randomised controlled trial , 2011, British Journal of Nutrition.

[106]  L. Woodward,et al.  Preschool executive functioning abilities predict early mathematics achievement. , 2010, Developmental psychology.

[107]  Jenny S. Radesky,et al.  Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. , 2008, American journal of epidemiology.

[108]  Rhoshel K. Lenroot,et al.  Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation , 2010, Neuropsychology Review.

[109]  C. Sisk,et al.  The neural basis of puberty and adolescence , 2004, Nature Neuroscience.

[110]  C. Hillman,et al.  A narrative review of physical activity, nutrition, and obesity to cognition and scholastic performance across the human lifespan. , 2011, Advances in Nutrition.

[111]  S. Waisbren,et al.  "Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al. , 2014 .

[112]  F. Trimarchi,et al.  Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. , 2004, The Journal of clinical endocrinology and metabolism.

[113]  S. Zeisel Importance of methyl donors during reproduction. , 2009, The American journal of clinical nutrition.

[114]  M. Zimmermann Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. , 2009, The American journal of clinical nutrition.

[115]  G. McCabe,et al.  Relation of maternal zinc nutriture to pregnancy outcome and infant development in an Egyptian village. , 1994, The American journal of clinical nutrition.

[116]  T. Roseboom,et al.  The Dutch famine and its long-term consequences for adult health. , 2006, Early human development.

[117]  Psycho-intellectual development of 3 year-old children with early gestational iodine deficiency. , 2005, Journal of pediatric endocrinology & metabolism : JPEM.

[118]  P. Marik,et al.  Narrative Review , 2012, Journal of intensive care medicine.

[119]  M. Onis,et al.  Is malnutrition declining? An analysis of changes in levels of child malnutrition since 1980. , 2000, Bulletin of the World Health Organization.

[120]  L. Allen,et al.  Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. , 2008, Nutrition reviews.

[121]  F. Bellisle Effects of diet on behaviour and cognition in children. , 2004, The British journal of nutrition.

[122]  H. Sachdev,et al.  Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials. , 2010, The American journal of clinical nutrition.

[123]  K. Lillycrop,et al.  Epigenetic mechanisms linking early nutrition to long term health. , 2012, Best practice & research. Clinical endocrinology & metabolism.

[124]  P. Levitt Structural and functional maturation of the developing primate brain. , 2003, The Journal of pediatrics.

[125]  Lars Bode,et al.  Poverty, obesity, and malnutrition: an international perspective recognizing the paradox. , 2007, Journal of the American Dietetic Association.

[126]  W. Wiersinga,et al.  Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy , 1999, Clinical endocrinology.

[127]  Michael K. Georgieff,et al.  Perinatal Iron Deficiency Alters Apical Dendritic Growth in Hippocampal CA1 Pyramidal Neurons , 2003, Developmental Neuroscience.

[128]  Eugenia K. Pallotto,et al.  Perinatal Outcome and Later Implications of Intrauterine Growth Restriction , 2006, Clinical obstetrics and gynecology.

[129]  M. Lopez-Espinosa,et al.  Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. , 2011, American journal of epidemiology.

[130]  E. Nelson,et al.  Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.

[131]  V. Gebski,et al.  The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. , 2005, Asia Pacific journal of clinical nutrition.

[132]  C. Nelson,et al.  Perinatal Iron Deficiency Decreases Cytochrome c Oxidase (CytOx) Activity in Selected Regions of Neonatal Rat Brain , 2001, Pediatric Research.

[133]  S. Zeisel The fetal origins of memory: the role of dietary choline in optimal brain development. , 2006, The Journal of pediatrics.

[134]  J. Stevenson Dietary influences on cognitive development and behaviour in children , 2006, Proceedings of the Nutrition Society.

[135]  John M. Davis,et al.  Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study , 2007, The Lancet.

[136]  T J Cole,et al.  Randomised trial of early diet in preterm babies and later intelligence quotient , 1998, BMJ.

[137]  M. Bloom,et al.  Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain , 2007, Lipids.

[138]  Yasuyuki Taki,et al.  Breakfast Staple Types Affect Brain Gray Matter Volume and Cognitive Function in Healthy Children , 2010, PloS one.

[139]  I. Tsuji,et al.  Effects of Maternal Multimicronutrient Supplementation on the Mental Development of Infants in Rural Western China: Follow-up Evaluation of a Double-Blind, Randomized, Controlled Trial , 2009, Pediatrics.

[140]  J. Beard Why iron deficiency is important in infant development. , 2008, The Journal of nutrition.

[141]  K. Michaelsen,et al.  Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort. , 2008, The American journal of clinical nutrition.

[142]  M. Born,et al.  A metaanalysis of research on iodine and its relationship to cognitive development. , 1996 .

[143]  H. Lagercrantz,et al.  Development of neurotransmitter systems during critical periods , 2004, Experimental Neurology.

[144]  U. Kapil Iodine deficiency. , 1986, Indian pediatrics.

[145]  R. Wurtman Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. , 2008, Metabolism: clinical and experimental.

[146]  A. Namasivayam,et al.  Effect of chronic protein restriction on motor co-ordination and brain neurotransmitters in albino rats. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[147]  Hans Wouters,et al.  Prenatal undernutrition and cognitive function in late adulthood , 2010, Proceedings of the National Academy of Sciences.

[148]  F. Vigneau,et al.  Relationship between maternal DHA and iron status and infants' cognitive performance. , 2011, Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada.

[149]  D. Hoffman,et al.  Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials. , 2009, Prostaglandins, leukotrienes, and essential fatty acids.

[150]  Xumei Zhang,et al.  Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells , 2009, Nutritional neuroscience.

[151]  B. de Benoist Conclusions of a WHO Technical Consultation on Folate and Vitamin B12 Deficiencies , 2008, Food and nutrition bulletin.

[152]  Maria Fernanda Laus,et al.  Early Postnatal Protein-Calorie Malnutrition and Cognition: A Review of Human and Animal Studies , 2011, International journal of environmental research and public health.

[153]  T. Kemper,et al.  Effect of Prenatal Protein Deprivation on Postnatal Granule Cell Generation in the Hippocampal Dentate Gyrus , 1996, Brain Research Bulletin.

[154]  M. Zimmermann The role of iodine in human growth and development. , 2011, Seminars in cell & developmental biology.

[155]  D. Spengler,et al.  Epigenetics of Early Child Development , 2011, Front. Psychiatry.

[156]  J. Parkington,et al.  Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens. , 2002, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[157]  H. Chugani A critical period of brain development: studies of cerebral glucose utilization with PET. , 1998, Preventive medicine.

[158]  T. Gera,et al.  Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials , 2005, Public Health Nutrition.

[159]  P. Santiago,et al.  Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. , 2009, The Journal of clinical endocrinology and metabolism.

[160]  Dorret I. Boomsma,et al.  Sex steroids and brain structure in pubertal boys and girls , 2009, Psychoneuroendocrinology.

[161]  Vitamin D Background Nutrient Reference Values for Australia and New Zealand 127 , 2007 .

[162]  S. Otte,et al.  Experience effects on brain development: possible contributions to psychopathology. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[163]  M. Schmidt,et al.  Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy. , 2004, The British journal of nutrition.

[164]  Susan E Carlson,et al.  Maternal DHA and the development of attention in infancy and toddlerhood. , 2004, Child development.

[165]  Denise L. Drane,et al.  A critical evaluation of the evidence on the association between type of infant feeding and cognitive development. , 2000, Paediatric and perinatal epidemiology.

[166]  E. Isaacs,et al.  Early diet and general cognitive outcome at adolescence in children born at or below 30 weeks gestation. , 2009, The Journal of pediatrics.

[167]  T. Ruffman,et al.  Iodine supplementation improves cognition in mildly iodine-deficient children. , 2009, The American journal of clinical nutrition.

[168]  Milos Judas,et al.  Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. , 2002, Cerebral cortex.

[169]  C. Drevon,et al.  Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. , 2001, Pediatrics.

[170]  Robert E Black,et al.  Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. , 2004, The American journal of clinical nutrition.

[171]  C. Wild,et al.  Dietary patterns and intelligence in early and middle childhood , 2009 .

[172]  G. Gökçay Breastfeeding and child cognitive development. , 2010, Child: care, health and development.

[173]  A. Simopoulos,et al.  The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases , 2008, Experimental biology and medicine.

[174]  L. Hooper,et al.  The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis , 2010, Nutrition journal.

[175]  C. Drevon,et al.  Effect of Supplementing Pregnant and Lactating Mothers With n-3 Very-Long-Chain Fatty Acids on Children's IQ and Body Mass Index at 7 Years of Age , 2008, Pediatrics.

[176]  D. Benton,et al.  Micro-nutrient supplementation and the intelligence of children , 2001, Neuroscience & Biobehavioral Reviews.

[177]  J. Dungan Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study , 2008 .

[178]  A. Prentice,et al.  Breast-feeding : early influences on later health , 2009 .

[179]  R. Vaidya,et al.  Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain , 2005, Molecular and Cellular Neuroscience.

[180]  Stephanie L. Lee,et al.  Neonatal thyroxine, maternal thyroid function, and child cognition. , 2009, The Journal of clinical endocrinology and metabolism.

[181]  Roberto Toro,et al.  Breastfeeding and brain structure in adolescence. , 2013, International journal of epidemiology.

[182]  M. Georgieff Nutrition and the developing brain: nutrient priorities and measurement. , 2007, The American journal of clinical nutrition.

[183]  V. Pop,et al.  Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3‐year follow‐up study , 2003, Clinical endocrinology.

[184]  Robert W. Thatcher,et al.  Maturation of the human frontal lobes: Physiological evidence for staging , 1991 .

[185]  I. Sanderson,et al.  Dietary regulation of gene expression , 2004, Current opinion in gastroenterology.

[186]  W. Maret,et al.  Zinc requirements and the risks and benefits of zinc supplementation. , 2006, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[187]  C. Van Petten,et al.  Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. , 2004, Neuropsychologia.

[188]  L. Pagani,et al.  Predicting academic and cognitive outcomes from weight status trajectories during childhood , 2013, International Journal of Obesity.

[189]  M. Black Micronutrient deficiencies and cognitive functioning. , 2003, The Journal of nutrition.

[190]  Reem Mustafa,et al.  A Comprehensive Review of Hypertension in Pregnancy , 2012, Journal of pregnancy.

[191]  M. Niculescu,et al.  High fat diet-induced maternal obesity alters fetal hippocampal development , 2009, International Journal of Developmental Neuroscience.

[192]  F. Chowdhury,et al.  Supplementation of fish-oil and soy-oil during pregnancy and psychomotor development of infants. , 2006, Journal of health, population, and nutrition.

[193]  P. Brundin,et al.  High‐fat diet impairs hippocampal neurogenesis in male rats , 2006, European journal of neurology.

[194]  A. Melse-Boonstra,et al.  Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. , 2010, Best practice & research. Clinical endocrinology & metabolism.

[195]  C. Agostoni,et al.  Effects of long-chain polyunsaturated fatty acid supplementation on fatty acid status and visual function in treated children with hyperphenylalaninemia. , 2000, The Journal of pediatrics.

[196]  Elizabeth L. Prado,et al.  Maternal Multiple Micronutrient Supplements and Child Cognition: A Randomized Trial in Indonesia , 2012, Pediatrics.

[197]  R. Díaz,et al.  The role of nutrition on epigenetic modifications and their implications on health. , 2012, Biochimie.

[198]  C. Transler,et al.  Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.

[199]  M. Longnecker,et al.  Fish Intake During Pregnancy and Early Cognitive Development of Offspring , 2004, Epidemiology.

[200]  K. Michaelsen,et al.  Effects of breast-feeding on cognitive function. , 2009, Advances in experimental medicine and biology.

[201]  P. Engle,et al.  INCAP Studies of Malnutrition and Cognitive Behavior , 2010, Food and nutrition bulletin.

[202]  M. D. D. do Carmo,et al.  Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory. , 2011, Nutrition reviews.

[203]  S. Patole,et al.  Long-chain polyunsaturated fatty acid supplementation in infants born at term. , 2011, The Cochrane database of systematic reviews.

[204]  Nikolaos Scarmeas,et al.  The good, bad, and ugly? , 2012, Neurology.

[205]  P. Guesnet,et al.  Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. , 2011, Biochimie.

[206]  Pauline Emmett,et al.  Are dietary patterns in childhood associated with IQ at 8 years of age? A population-based cohort study , 2011, Journal of Epidemiology & Community Health.

[207]  Review: iron treatment does not improve psychomotor development and cognitive function at 30 days in children with iron deficiency anaemia , 2002, Evidence-based mental health.

[208]  B. Koletzko,et al.  Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. , 2011, The American journal of clinical nutrition.

[209]  M. Bornstein,et al.  Maternal gestational zinc supplementation does not influence multiple aspects of child development at 54 mo of age in Peru. , 2010, The American journal of clinical nutrition.

[210]  O. Harel,et al.  Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. , 2007, The American journal of clinical nutrition.

[211]  P. Coyle,et al.  Maternal dietary zinc supplementation prevents aberrant behaviour in an object recognition task in mice offspring exposed to LPS in early pregnancy , 2009, Behavioural Brain Research.

[212]  D. Benton 70th Anniversary Conference on 'Vitamins in early development and healthy aging: impact on infectious and chronic disease' Symposium 1: Vitamins and cognitive development and performance Vitamins and neural and cognitive developmental outcomes in children , 2012 .

[213]  J. Giedd,et al.  Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging , 2006, Neuroscience & Biobehavioral Reviews.

[214]  G. Fuchs,et al.  Zinc supplementation during pregnancy and effects on mental development and behaviour of infants: a follow-up study , 2002, The Lancet.