Membrane-bound transcription factors: regulated release by RIP or RUP.

[1]  X. Chen,et al.  ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.

[2]  S. Jentsch,et al.  Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing , 2000, Cell.

[3]  P. Espenshade,et al.  Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes , 2000, Cell.

[4]  K. Mori.  Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum , 2000, Cell.

[5]  Joseph L Goldstein,et al.  Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to Humans , 2000, Cell.

[6]  Peter Walter,et al.  A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response , 1999, Cell.

[7]  P. Espenshade,et al.  Transport-Dependent Proteolysis of SREBP Relocation of Site-1 Protease from Golgi to ER Obviates the Need for SREBP Transport to Golgi , 1999, Cell.

[8]  R. Losick,et al.  A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[9]  T. Kornberg,et al.  Ci: a complex transducer of the hedgehog signal. , 1999, Trends in genetics : TIG.

[10]  K. Mori,et al.  Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. , 1999, Molecular biology of the cell.

[11]  B. Strooper,et al.  Presenilins: molecular switches between proteolysis and signal transduction , 1999, Trends in Neurosciences.

[12]  M. Brown,et al.  A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. S. Brown,et al.  Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  P. Espenshade,et al.  Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins* , 1999, The Journal of Biological Chemistry.

[15]  Philip A Beachy,et al.  Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression , 1999, Cell.

[16]  J. Goldstein,et al.  Membrane Topology of S2P, a Protein Required for Intramembranous Cleavage of Sterol Regulatory Element-binding Proteins* , 1999, The Journal of Biological Chemistry.

[17]  D. Selkoe,et al.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.

[18]  I. Shimomura,et al.  Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. , 1999, Current opinion in lipidology.

[19]  D. Garfinkel,et al.  MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae. , 1999, Genetics.

[20]  D. Selkoe,et al.  The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease , 1998 .

[21]  P. Espenshade,et al.  Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. , 1998, Molecular cell.

[22]  J. Goldstein,et al.  Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing Domain* , 1998, The Journal of Biological Chemistry.

[23]  S. Jentsch,et al.  Role of the proteasome in membrane extraction of a short‐lived ER‐transmembrane protein , 1998, The EMBO journal.

[24]  S K Burley,et al.  Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution. , 1998, Structure.

[25]  G. Struhl,et al.  Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb , 1998, Nature.

[26]  M. T. Hasan,et al.  Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. , 1997, Molecular cell.

[27]  J. Goldstein,et al.  Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein* , 1997, The Journal of Biological Chemistry.

[28]  T. Kornberg,et al.  Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor , 1997, Cell.

[29]  J. Goldstein,et al.  Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2* , 1997, The Journal of Biological Chemistry.

[30]  J. Goldstein,et al.  The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.

[31]  R. Huber,et al.  Structure of 20S proteasome from yeast at 2.4Å resolution , 1997, Nature.

[32]  X. Hua,et al.  Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein , 1996, Cell.

[33]  Charles E. Martin,et al.  Fatty Acid-responsive Control of mRNA Stability , 1996, The Journal of Biological Chemistry.

[34]  S. Hwang,et al.  Regulatory Elements That Control Transcription Activation and Unsaturated Fatty Acid-mediated Repression of the Saccharomyces cerevisiae OLE1 Gene (*) , 1996, The Journal of Biological Chemistry.

[35]  X. Hua,et al.  Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection * , 1995, The Journal of Biological Chemistry.

[36]  Tom Maniatis,et al.  The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB , 1994, Cell.

[37]  X. Hua,et al.  SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis , 1994, Cell.

[38]  M. Brown,et al.  SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Admon,et al.  SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene , 1993, Cell.

[40]  T. Maniatis,et al.  Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway , 1991, Nature.

[41]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[42]  W. Leonard,et al.  Jaks and STATs: biological implications. , 1998, Annual review of immunology.

[43]  M. Hochstrasser.  Ubiquitin-dependent protein degradation. , 1996, Annual review of genetics.

[44]  R. Losick,et al.  Molecular genetics of sporulation in Bacillus subtilis. , 1996, Annual review of genetics.