The SH2 Domain: A Prototype for Protein Interaction Modules

Originally published in: Modular Protein Domains. Edited by Giovanni Cesareni, Mario Gimona, Marius Sudol and Michael Yaffe. Copyright © 2005 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3-527-30813-2 The sections in this article are The Multidomain Nature of Signaling Proteins and Identification of the SH2 Domain SH2 Domains as a Prototype for Interaction Domains Structure and Binding Properties of SH2 Domains Different Modes of SH2 Domain-Phosphopeptide Recognition Signaling Pathways and Networks Plasticity of SH2 Domains SH2 Domain Dimerization Tandem SH2 Domains Composite and Complex Interaction Domains Allosteric Regulation SH2 Domains and Disease Conclusions Keywords: Modular protein domains; adaptors; SH2 domain; prototype for interaction domains; multidomain nature; signaling proteins; structure and binding properties; phosphopeptide recognition; signaling pathways; signaling networks; tandem SH2 domains; allosteric regulation; SH2 domains and disease

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