Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy

The contribution of recurring seizures to the progression of epileptogenesis is debated. Seizure‐induced brain damage is not conclusively demonstrated either in humans or in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on postsurgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug‐resistant focal epilepsy.

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