LED-Based Functional Photoacoustics—Portable and Affordable Solution for Preclinical Cancer Imaging

Photoacoustic imaging (PAI) is an imaging modality with promising results in cancer theranostics, both in preclinical and clinical applications. Its applicability in image-guided drug delivery and monitoring therapeutic response holds great promise for clinical translation. Current PAI techniques rely on using bulky lasers to provide the nanosecond pulsed light for photoacoustic signal generation. Tremendous growth in semiconductor industry within the last decade has led to creation of low-cost powerful LEDs that can be used as an alternate light source in lieu of laser to generate photoacoustic signal. In this chapter, we provide an overview of PAI usage in preclinical cancer research and provide examples of the LED based PAI performance in similar settings. LEDs will play a major role in catapulting PAI into clinics at an earlier pace and low cost than expected.

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