High-Value Phytochemicals from Grape Cane Waste: Potential Value-Added Viticultural Sources of Trans-Resveratrol and Trans-e-Viniferin with Medicinal and Anti-Phytopathogenic Applications

Grape canes as agricultural waste from commercial viticultural activities represent a potentially important source of the well-known medicinal and anti-phytopathogenic stilbene compounds trans-resveratrol and trans-e-viniferin. Reports in the literature suggest that concentrations of these compounds range up to 5 mg/g dw and 2 mg/g dw, respectively, and can be quantitatively extracted from the cane residue using low-cost, environmental benign, and non-toxic aqueous alcoholic solvent systems such as ethanol:water mixtures. With current commercial values of these compounds between US$2,000 to US$3,000 per kg, established stilbene yields from cane waste could represent an agricultural coproduct valued at US$2,000 to US$3,000 per hectare of production. At the present worldwide wine grape production of 8,000,000 ha, the extraction of trans-resveratrol and trans-e-viniferin from grape cane waste would have an estimated global economic value of >$30 billion.

[1]  A. Resurreccion,et al.  Elicitation of resveratrol in peanut kernels by application of abiotic stresses. , 2005, Journal of agricultural and food chemistry.

[2]  M. Olivares-Marín,et al.  Development of activated carbon using vine shoots (Vitis vinifera) and its use for wine treatment. , 2005, Journal of agricultural and food chemistry.

[3]  J. Ingham 3,5,4′-trihydroxystilbene as a phytoalexin from groundnuts (Arachis hypogaea) , 1976 .

[4]  J. Orea,et al.  Resveratrol treatment controls microbial flora, prolongs shelf life, and preserves nutritional quality of fruit. , 2005, Journal of agricultural and food chemistry.

[5]  F. Tomás-Barberán,et al.  Effect of postharvest ultraviolet irradiation on resveratrol and other phenolics of cv. Napoleon table grapes. , 2000, Journal of agricultural and food chemistry.

[6]  P. Langcake Disease resistance of Vitis spp. and the production of the stress metabolites resveratrol, ε-viniferin, α-viniferin and pterostilbene , 1981 .

[7]  F. Berthou,et al.  Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. , 2003, Life sciences.

[8]  M. Yáñez,et al.  (−)-Trans-ε-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity , 2006 .

[9]  Himanish Das,et al.  Useful Byproducts from Cellulosic Wastes of Agriculture and Food Industry—A Critical Appraisal , 2004, Critical reviews in food science and nutrition.

[10]  R. Ben-arie,et al.  Phytoalexin elicitation in grape berries and their susceptibility toRhizopus stolonifer , 1997 .

[11]  J. Espín,et al.  Comparison of ozone and UV-C treatments on the postharvest stilbenoid monomer, dimer, and trimer induction in var. 'Superior' white table grapes. , 2006, Journal of agricultural and food chemistry.

[12]  K. Gindro,et al.  Glycosylation and oxidative dimerization of resveratrol are respectively associated to sensitivity and resistance of grapevine cultivars to downy mildew , 2004 .

[13]  W. Dercks,et al.  The significance of stilbene phytoalexins in the Plasmopara viticola-grapevine interaction , 1989 .

[14]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[15]  Norman R. Farnsworth,et al.  Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes , 1997, Science.

[16]  F. Tomás-Barberán,et al.  Quality and enhancement of bioactive phenolics in cv. Napoleon table grapes exposed to different postharvest gaseous treatments. , 2003, Journal of agricultural and food chemistry.

[17]  C. Andary,et al.  Histochemical studies on the interaction between three species of grapevine, Vitis vinifera, V. rupestris and V. rotundifolia and the downy mildew fungus, Plasmopara viticola , 1995 .

[18]  R. Chiou,et al.  Peanut roots as a source of resveratrol. , 2002, Journal of agricultural and food chemistry.

[19]  A. Raal,et al.  Survey of grapevine Vitis vinifera stem polyphenols by liquid chromatography-diode array detection-tandem mass spectrometry. , 2006, Journal of agricultural and food chemistry.

[20]  N. Paiva,et al.  Constitutive accumulation of a resveratrol-glucoside in transgenic alfalfa increases resistance to Phoma medicaginis. , 2000, Molecular plant-microbe interactions : MPMI.

[21]  M. Adrian,et al.  Biological Activity of Resveratrol, a Stilbenic Compound from Grapevines, Against Botrytis cinerea, the Causal Agent for Gray Mold , 2004, Journal of Chemical Ecology.

[22]  J. Espín,et al.  Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses. , 2002, Journal of agricultural and food chemistry.

[23]  P. Kopp Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? , 1998, European journal of endocrinology.

[24]  G. Hoos,et al.  Influence of resveratrol on germination of conidia and mycelial growth of Botrytis cinerea and Phomopsis viticola. , 1990 .

[25]  P. Langcake,et al.  The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury , 1976 .

[26]  R. Ben-arie,et al.  Ozone for control of post-harvest decay of table grapes caused byRhizopus stolonifer , 1996 .

[27]  J. L. González,et al.  Improving postharvest resistance in fruits by external application of trans-resveratrol. , 2003, Journal of agricultural and food chemistry.

[28]  F. Nepveu,et al.  Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media. , 2002, Journal of agricultural and food chemistry.

[29]  Antonino Cattaneo,et al.  Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate , 2006, Current Biology.

[30]  J. Espín,et al.  Differential stilbene induction susceptibility of seven red wine grape varieties upon post-harvest UV-C irradiation , 2003 .