High Levels of Serum C‐Reactive Protein Are Associated with Greater Risk of All‐Cause Mortality, but Not Dementia, in the Oldest‐Old: Results from The 90+ Study

OBJECTIVES: To evaluate whether high levels of C‐reactive protein (CRP) in serum are associated with greater risk of all‐cause dementia or mortality in the oldest‐old.

[1]  M. Dick,et al.  Neuropsychological data in nondemented oldest old: The 90+ Study , 2007, Journal of clinical and experimental neuropsychology.

[2]  N. Cook,et al.  High-Sensitivity C-Reactive Protein and Cognitive Function in Older Women , 2006, Epidemiology.

[3]  Dc Washington.  Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[4]  Lisa M. Schwartz,et al.  Distribution of C-reactive protein values in the United States. , 2005, The New England journal of medicine.

[5]  A. Bachu.  Current Population Reports , 1999 .

[6]  T. Strandberg,et al.  Predictors of cognitive decline and mortality of aged people over a 10-year period. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[7]  L. Kuller,et al.  Inflammation biomarkers and near-term death in older men. , 2007, American journal of epidemiology.

[8]  A. Hofman,et al.  Systemic Markers of Inflammation and Cognitive Decline in Old Age , 2007, Journal of the American Geriatrics Society.

[9]  Janice E Graham,et al.  Prevalence and severity of cognitive impairment with and without dementia in an elderly population , 1997, The Lancet.

[10]  C. Patterson,et al.  Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging , 2007, Neurobiology of Aging.

[11]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[12]  T. Strandberg,et al.  C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[13]  W. März,et al.  The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study). , 2004, European heart journal.

[14]  L. Launer,et al.  Midlife C-reactive protein and risk of cognitive decline: A 31-year follow-up , 2009, Neurobiology of Aging.

[15]  R. Schmidt,et al.  Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study , 2002, Annals of neurology.

[16]  T. Kurosaki,et al.  Measurement of functional activities in older adults in the community. , 1982, Journal of gerontology.

[17]  S. Bandinelli,et al.  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC only. TRIALS The , 2004 .

[18]  J. Smit,et al.  Serum inflammatory proteins and cognitive decline in older persons , 2005, Neurology.

[19]  Irving Kushner,et al.  C-reactive Protein* , 2004, Journal of Biological Chemistry.

[20]  T. Lehtimäki,et al.  Survival related to plasma C-reactive-protein in nonagenarians is modified by apolipoprotein E genotype. , 2007, Clinical chemistry.

[21]  S. Rubin,et al.  Inflammatory markers and cognition in well-functioning African-American and white elders , 2003, Neurology.

[22]  T. Lehtimäki,et al.  Apolipoprotein E genotype is related to plasma levels of C‐reactive protein and lipids and to longevity in nonagenarians , 2006, Clinical endocrinology.

[23]  M. Jylhä,et al.  Self-reported medical history and self-rated health at age 90. Agreement with medical records , 2007, Aging clinical and experimental research.

[24]  Mark B Pepys,et al.  C-reactive protein: a critical update. , 2003, The Journal of clinical investigation.

[25]  A. Hofman,et al.  Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. , 2004, Archives of neurology.