Biological markers in the peritoneal dialysate effluent: are they useful.

A review is given on biomarkers in peritoneal effluent. It comprises methods to distinguish between diffusion and local production. This is followed by examples of various biomarkers. Their potential use is discussed in 4 situations: inherent fast transporters, longitudinal follow-up of patients, biocompatibility testing of new dialysis solutions, and their potential use in the detection of patients who are likely to develop encapsulating peritoneal sclerosis.

[1]  W. Smit,et al.  The cellular contribution to effluent potassium and its relation to free water transport during peritoneal dialysis. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[2]  R. Krediet,et al.  Effluent Hydroxyproline in Experimental Peritoneal Dialysis , 2007, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[3]  J. Korevaar,et al.  Evaluation of Peritoneal Transport and Membrane Status in Peritoneal Dialysis: Focus on Incident Fast Transporters , 2007, American Journal of Nephrology.

[4]  R. Krediet,et al.  Determinants of Peritoneal Solute Transport Rates in Newly Started Nondiabetic Peritoneal Dialysis Patients , 2004, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[5]  K. Craig,et al.  The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane. , 2004, Kidney international.

[6]  R. Krediet,et al.  Evaluation of effluent markers cancer antigen 125, vascular endothelial growth factor, and interleukin-6: relationship with peritoneal transport. , 2004, Advances in peritoneal dialysis. Conference on Peritoneal Dialysis.

[7]  F. Schaefer,et al.  Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis. , 2003, Journal of the American Society of Nephrology : JASN.

[8]  P. Stenvinkel,et al.  Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. , 2002, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[9]  R. Krediet.  Dialysate Cancer Antigen 125 Concentration as Marker of Peritoneal Membrane Status in Patients Treated with Chronic Peritoneal Dialysis , 2001, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[10]  R. Krediet,et al.  Bicarbonate/lactate-based peritoneal dialysis solution increases cancer antigen 125 and decreases hyaluronic acid levels. , 2001, Kidney international.

[11]  A. Christensson,et al.  Long-term clinical effects of a peritoneal dialysis fluid with less glucose degradation products. , 2001, Kidney international.

[12]  M. Levi,et al.  Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis , 1999, Pediatric Nephrology.

[13]  D. Struijk,et al.  Are phospholipase A2 and nitric oxide involved in the alterations in peritoneal transport during CAPD peritonitis? , 1998, The Journal of laboratory and clinical medicine.

[14]  D. Struijk,et al.  Longitudinal follow-up of CA125 in peritoneal effluent. , 1997, Kidney international.

[15]  D. Zemel,et al.  Dialysate Markers of Peritoneal Tissue during Peritonitis and in Stable CAPD , 1995, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[16]  M. Daha,et al.  Complement in Serum and Dialysate in Children on Continuous Ambulatory Peritoneal Dialysis , 1995, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[17]  D. Zemel,et al.  Appearance of tumor necrosis factor-alpha and soluble TNF-receptors I and II in peritoneal effluent of CAPD. , 1994, Kidney international.

[18]  D. Struijk,et al.  Effect of dialysate osmolarity on the transport of low-molecular weight solutes and proteins during CAPD. , 1993, Kidney international.

[19]  D. Struijk,et al.  Effects of renal failure on complement C3d levels. , 1991, Nephron.