Recurring exon deletions in the haptoglobin ( HP ) gene associate with lower blood cholesterol levels

[1]  S. Mccarroll,et al.  A Rapid Molecular Approach for Chromosomal Phasing , 2015, PloS one.

[2]  Y. Koda,et al.  Genetic factors associated with serum haptoglobin level in a Japanese population. , 2014, Clinica chimica acta; international journal of clinical chemistry.

[3]  Philip L. F. Johnson,et al.  The complete genome sequence of a Neandertal from the Altai Mountains , 2013, Nature.

[4]  Fengtang Yang,et al.  Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis , 2013, Human Genetics.

[5]  E. Rimm,et al.  Currently available versions of genome-wide association studies cannot be used to query the common haptoglobin copy number variant. , 2013, Journal of the American College of Cardiology.

[6]  L. Tian,et al.  VPO1 Mediates ApoE Oxidation and Impairs the Clearance of Plasma Lipids , 2013, PloS one.

[7]  M. Spagnuolo,et al.  Analysis of the haptoglobin binding region on the apolipoprotein A‐I‐derived P2a peptide , 2013, Journal of peptide science : an official publication of the European Peptide Society.

[8]  O. Delaneau,et al.  Supplementary Information for ‘ Improved whole chromosome phasing for disease and population genetic studies ’ , 2012 .

[9]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[10]  Adrian W. Briggs,et al.  A High-Coverage Genome Sequence from an Archaic Denisovan Individual , 2012, Science.

[11]  R. Durbin,et al.  Revising the human mutation rate: implications for understanding human evolution , 2012, Nature Reviews Genetics.

[12]  Tom R. Gaunt,et al.  Molecular and Population Analysis of Natural Selection on the Human Haptoglobin Duplication , 2012, Annals of human genetics.

[13]  J. Marchini,et al.  Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.

[14]  Tom R. Gaunt,et al.  Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol , 2012, Gene.

[15]  P. Elliott,et al.  A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels , 2012, PloS one.

[16]  Mary Goldman,et al.  The UCSC Genome Browser database: extensions and updates 2011 , 2011, Nucleic Acids Res..

[17]  Jeff Mellen,et al.  High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number , 2011, Analytical chemistry.

[18]  Timothy J. Durham,et al.  "Systematic" , 1966, Comput. J..

[19]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[20]  Tanya M. Teslovich,et al.  Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.

[21]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[22]  Manolis Kellis,et al.  Discovery and characterization of chromatin states for systematic annotation of the human genome , 2010, Nature Biotechnology.

[23]  Tomas W. Fitzgerald,et al.  Origins and functional impact of copy number variation in the human genome , 2010, Nature.

[24]  M. Spagnuolo,et al.  Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes , 2009, The FEBS journal.

[25]  A. Fasano,et al.  Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2 , 2009, Proceedings of the National Academy of Sciences.

[26]  S. Moestrup,et al.  Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging. , 2009, Blood.

[27]  L. Cigliano,et al.  Haptoglobin binds apolipoprotein E and influences cholesterol esterification in the cerebrospinal Fluid , 2009, Journal of neurochemistry.

[28]  G. Abecasis,et al.  Genotype imputation. , 2009, Annual review of genomics and human genetics.

[29]  Y. Koda,et al.  TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2). , 2008, Clinical chemistry.

[30]  Sharon R. Browning,et al.  Missing data imputation and haplotype phase inference for genome-wide association studies , 2008, Human Genetics.

[31]  Joshua M. Korn,et al.  Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs , 2008, Nature Genetics.

[32]  Anders Larsson,et al.  Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. , 2008, The New England journal of medicine.

[33]  N. Zolotarjova,et al.  Multi-component immunoaffinity subtraction and reversed-phase chromatography of human serum. , 2008, Methods in molecular biology.

[34]  Zhaohui S. Qin,et al.  A second generation human haplotype map of over 3.1 million SNPs , 2007, Nature.

[35]  L. Cigliano,et al.  Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase. , 2007, Biochemistry.

[36]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[37]  P. Donnelly,et al.  A new multipoint method for genome-wide association studies by imputation of genotypes , 2007, Nature Genetics.

[38]  D. Reich,et al.  Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.

[39]  M. Olivier A haplotype map of the human genome. , 2003, Nature.

[40]  M. Olivier A haplotype map of the human genome , 2003, Nature.

[41]  Mark I. McCarthy,et al.  Early Life Factors and Blood Pressure at Age 31 Years in the 1966 Northern Finland Birth Cohort , 2004, Hypertension.

[42]  E. Benjamin,et al.  Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort. , 2004, Atherosclerosis.

[43]  R. Kronmal,et al.  Multi-Ethnic Study of Atherosclerosis: objectives and design. , 2002, American journal of epidemiology.

[44]  A. Kastrati,et al.  Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. , 2002, Clinical chemistry.

[45]  A. Levy,et al.  Structure-function analysis of the antioxidant properties of haptoglobin. , 2001, Blood.

[46]  M. Kodaira,et al.  Chimerism in humans after intragenic recombination at the haptoglobin locus during early embryogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R N Bergman,et al.  Mapping Genes for NIDDM: Design of the Finland—United States Investigation of NIDDM Genetics (FUSION) Study , 1998, Diabetes Care.

[48]  R A Kronmal,et al.  Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. , 1998, JAMA.

[49]  J. Delanghe,et al.  Biological and clinical significance of haptoglobin polymorphism in humans. , 1996, Clinical chemistry.

[50]  J. Gardin,et al.  Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women. The CARDIA study. Coronary Artery Risk Development in Young Adults. , 1995, Circulation.

[51]  N. Maeda,et al.  The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[52]  S. Shindo Haptoglobin subtyping with anti‐haptoglobin α chain antibodies , 1990 .

[53]  S. Shindo Haptoglobin subtyping with anti-haptoglobin alpha chain antibodies. , 1990, Electrophoresis.

[54]  A. Folsom,et al.  The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. , 1989, American journal of epidemiology.

[55]  N. Maeda,et al.  Complex events in the evolution of the haptoglobin gene cluster in primates. , 1988, The Journal of biological chemistry.

[56]  N. Maeda,et al.  Duplication within the haptoglobin Hp2 gene , 1984, Nature.

[57]  J. Greer,et al.  Structure and assembly of haptoglobin polymers by electron microscopy. , 1984, Journal of molecular biology.

[58]  O. Smithies,et al.  Inheritance of haptoglobin subtypes. , 1962, American journal of human genetics.

[59]  A. Allison,et al.  The Binding of Haemoglobin by Plasma Proteins (Haptoglobins) , 1957, British medical journal.

[60]  O. Smithies,et al.  Genetic Control of some Serum Proteins in Normal Humans , 1955, Nature.