Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase
暂无分享,去创建一个
[1] K. Brøsen,et al. Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine , 2004, European Journal of Clinical Pharmacology.
[2] W. Kalow. Genetic variation in the human hepatic cytochrome P-450 system , 2004, European Journal of Clinical Pharmacology.
[3] T. Leemann,et al. Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers , 2004, European Journal of Clinical Pharmacology.
[4] K. Brøsen,et al. A dose-effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man. , 1990, British journal of clinical pharmacology.
[5] K. Brøsen. Recent Developments in Hepatic Drug Oxidation Implications for Clinical Pharmacokinetics , 1990, Clinical pharmacokinetics.
[6] K. Brøsen,et al. Quinidine kinetics after a single oral dose in relation to the sparteine oxidation polymorphism in man. , 1990, British journal of clinical pharmacology.
[7] B. Angelin,et al. Interactions in the renal and biliary elimination of digoxin: Stereoselective difference between quinine and quinidine , 1990, Clinical pharmacology and therapeutics.
[8] D. Roden,et al. Effect of low dose quinidine on encainide pharmacokinetics and pharmacodynamics. Influence of genetic polymorphism. , 1989, The Journal of pharmacology and experimental therapeutics.
[9] K. Midha,et al. Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism. , 1989, Xenobiotica; the fate of foreign compounds in biological systems.
[10] R. Dahlqvist,et al. Inhibition of desipramine 2‐hydroxylation by quinidine and quinine , 1988, Clinical pharmacology and therapeutics.
[11] K. Midha,et al. Influence of urinary pH on the disposition of methoxyphenamine and three metabolites in humans. , 1987, Journal of pharmaceutical sciences.
[12] A. Boobis,et al. Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine. , 1986, British journal of clinical pharmacology.
[13] D. Notterman,et al. Stereoselective renal tubular secretion of quinidine and quinine , 1986, Clinical pharmacology and therapeutics.
[14] T. Inaba,et al. Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo. , 1986, British journal of clinical pharmacology.
[15] S. Otton,et al. Sparteine oxidation is practically abolished in quinidine-treated patients. , 1986, British journal of clinical pharmacology.
[16] G McKay,et al. Metabolism of methoxyphenamine in extensive and poor metabolizers of debrisoquin , 1985, Clinical pharmacology and therapeutics.
[17] T. Henthorn,et al. Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes. , 1985, Biochemical pharmacology.
[18] W. Kalow,et al. In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase. , 1985, Drug metabolism and disposition: the biological fate of chemicals.
[19] W. Kalow,et al. Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs. , 1984, Life sciences.
[20] K. Midha,et al. Identification of new secondary metabolites of methoxyphenamine in man. , 1983, Xenobiotica; the fate of foreign compounds in biological systems.