Transposon mutagenesis in Legionella pneumophila. II.--Mutants exhibiting impaired intracellular growth within cultured macrophages and reduced virulence in vivo.

[1]  J. Hacker,et al.  Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila , 1991, Molecular microbiology.

[2]  M. Horwitz,et al.  An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease. , 1990, The Journal of clinical investigation.

[3]  L. Bermudez,et al.  Oxidative and non-oxidative intracellular killing of Mycobacterium avium complex. , 1989, Microbial pathogenesis.

[4]  P. Berche,et al.  Loss of catalase activity in Tn1545-induced mutants does not reduce growth of Listeria monocytogenes in vivo , 1989, Infection and immunity.

[5]  L. Tompkins,et al.  Analysis of a cloned sequence of Legionella pneumophila encoding a 38 kD metalloprotease possessing haemolytic and cytotoxic activities , 1989, Molecular microbiology.

[6]  T. Byrd,et al.  Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. , 1989, The Journal of clinical investigation.

[7]  C. Mody,et al.  A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection , 1989, Infection and immunity.

[8]  P. Hoffman,et al.  Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities , 1989, Infection and immunity.

[9]  J. Blom,et al.  Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes , 1989, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[10]  N. Cianciotto,et al.  Site-specific mutagenesis in Legionella pneumophila by allelic exchange using counterselectable ColE1 vectors , 1988 .

[11]  W. Johnson,et al.  Virulence conversion of Legionella pneumophila: a one-way phenomenon , 1988, Infection and immunity.

[12]  E. Pearlman,et al.  Growth of Legionella pneumophila in a human macrophage-like (U937) cell line. , 1988, Microbial pathogenesis.

[13]  H. Shuman,et al.  Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes , 1988, Infection and immunity.

[14]  P. Rajagopalan,et al.  Monoclonal antibody reactivity as a virulence marker for Legionella pneumophila serogroup 1 strains. , 1988, The Journal of infectious diseases.

[15]  J. W. Conlan,et al.  Immunocytochemical demonstration of the association between Legionella pneumophila, its tissue‐destructive protease, and pulmonary lesions in experimental Legionnaires' disease , 1987, The Journal of pathology.

[16]  M. Horwitz,et al.  Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes , 1987, The Journal of experimental medicine.

[17]  E. Borden,et al.  Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures. , 1987, Journal of immunology.

[18]  B. Stocker,et al.  Effect of different purine auxotrophic mutations on mouse-virulence of a Vi-positive strain of Salmonella dublin and of two strains of Salmonella typhimurium. , 1987, Microbial pathogenesis.

[19]  R. Jepras,et al.  The effect of oxygen-dependent antimicrobial systems on strains of Legionella pneumophila of different virulence , 1986, Journal of Hygiene.

[20]  J. W. Conlan,et al.  Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung. , 1986, Journal of general microbiology.

[21]  D. Ramsay,et al.  Development of a standardized subgrouping scheme for Legionella pneumophila serogroup 1 using monoclonal antibodies , 1986, Journal of clinical microbiology.

[22]  B. Iglewski,et al.  Purification and characterization of an extracellular protease of Legionella pneumophila , 1986, Infection and immunity.

[23]  J. W. Conlan,et al.  The relationship between the serogroup antigen and lipopolysaccharide of Legionella pneumophila , 1986, Journal of Hygiene.

[24]  L. Pine,et al.  Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species , 1986, Journal of clinical microbiology.

[25]  M. T. Pope,et al.  Properties of an acid phosphatase from Legionella micdadei which blocks superoxide anion production by human neutrophils. , 1985, Archives of biochemistry and biophysics.

[26]  Macfarlane Jt,et al.  The Protean Manifestations of Legionnaires' Disease , 1985, Journal of the Royal College of Physicians of London.

[27]  J. Kurtz,et al.  Legionella pneumophila serogroup 1 subgrouping by monoclonal antibodies – an epidemiological tool , 1985, Journal of Hygiene.

[28]  R. Jepras,et al.  A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs , 1985, Journal of Hygiene.

[29]  W. Baine.  Cytolytic and phospholipase C activity in Legionella species. , 1985, Journal of general microbiology.

[30]  R. Fitzgeorge.  The effect of antibiotics on the growth of Legionella pneumophila in guinea-pig alveolar phagocytes infected in vivo by an aerosol. , 1985, The Journal of infection.

[31]  D. Gump,et al.  The kinetics of early inflammatory events during experimental pneumonia due to Legionella pneumophila in guinea pigs. , 1983, The Journal of infectious diseases.

[32]  M. Selsted,et al.  Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages , 1983, Infection and immunity.

[33]  P. Hambleton,et al.  EXPERIMENTAL TRANSMISSION OF LEGIONNAIRES' DISEASE BY EXPOSURE TO AEROSOLS OF LEGIONELLA PNEUMOPHILA , 1981, The Lancet.

[34]  K. Jann,et al.  Natural resistance of mice to Salmonella typhimurium: bactericidal activity and chemiluminescence response of murine peritoneal macrophages. , 1981, Journal of general microbiology.

[35]  T. Burrows,et al.  The effects of biochemical mutation on the virulence of Bacterium typhosum: the virulence of mutants. , 1950, British journal of experimental pathology.

[36]  M. Tully,et al.  Transposon mutagenesis in Legionella pneumophila. I.--Persistence of suicide and broad host-range plasmids. , 1992, Research in microbiology.

[37]  J. W. Conlan,et al.  In vivo production of a tissue-destructive protease by Legionella pneumophila in the lungs of experimentally infected guinea-pigs. , 1988, Journal of general microbiology.

[38]  A. Pühler,et al.  A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative Bacteria , 1983, Bio/Technology.