Advanced Normalization Tools for Cardiac Motion Correction

We present our submission to the STACOM 2014 MoCo challenge for motion correction of dynamic contrast myocardial perfusion MRI. Our submission is based on the publicly available Advanced Normalization Tools (ANTs) specifically tailored for this problem domain. We provide a brief description with actual code calls to facilitate reproducibility. Time plots and \(K^{trans}\) values, based on the validation methodology of [11], are also provided to determine clinically relevant performance levels.

[1]  J. Gee,et al.  The Insight ToolKit image registration framework , 2014, Front. Neuroinform..

[2]  Brian B. Avants,et al.  Explicit B-spline regularization in diffeomorphic image registration , 2013, Front. Neuroinform..

[3]  Brian B. Avants,et al.  Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain , 2008, Medical Image Anal..

[4]  Paul Dupuis,et al.  Variational problems on ows of di eomorphisms for image matching , 1998 .

[5]  Brian B. Avants,et al.  N4ITK: Improved N3 Bias Correction , 2010, IEEE Transactions on Medical Imaging.

[6]  Brian B. Avants,et al.  Evaluation of Registration Methods on Thoracic CT: The EMPIRE10 Challenge , 2011, IEEE Transactions on Medical Imaging.

[7]  Arno Klein,et al.  Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration , 2009, NeuroImage.

[8]  Brian B. Avants,et al.  The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) , 2015, IEEE Transactions on Medical Imaging.

[9]  Alain Trouvé,et al.  Computing Large Deformation Metric Mappings via Geodesic Flows of Diffeomorphisms , 2005, International Journal of Computer Vision.

[10]  E. DiBella,et al.  Comparison of myocardial perfusion estimates from dynamic contrast‐enhanced magnetic resonance imaging with four quantitative analysis methods , 2010, Magnetic resonance in medicine.

[11]  Jayaram K. Udupa,et al.  New variants of a method of MRI scale standardization , 2000, IEEE Transactions on Medical Imaging.

[12]  Ganesh Adluru,et al.  The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study , 2011, The International Journal of Cardiovascular Imaging.

[13]  Jean-Philippe Thirion,et al.  Image matching as a diffusion process: an analogy with Maxwell's demons , 1998, Medical Image Anal..

[14]  Arno Klein,et al.  A reproducible evaluation of ANTs similarity metric performance in brain image registration , 2011, NeuroImage.

[15]  Stephen M. Smith,et al.  SUSAN—A New Approach to Low Level Image Processing , 1997, International Journal of Computer Vision.