Effects of dexmedetomidine on the protection of hyperoxia-induced lung injury in newborn rats.

Dexmedetomidine (Dex) is a specific agonist of α2-adrenoceptor and was reported to have protective effect on a variety of organs, however the effect of Dex on hyperoxia-induced lung injury remains unknown. In the present study, Dex was administrated to newborn rats and its effect against hyperoxia-induced lung injury was examined. The results showed that, Dex significantly attenuated the aberration, macrophage infiltration, inflammatory responses and pulmonary edema induced by hyperoxia. In addition, the down-regulation of AQP1 was also reversed by Dex. These data indicate that Dex may be a potential therapy in the prevention of hyperoxia-induced lung injury in infants.

[1]  M. Durmus,et al.  The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats. , 2013, The Journal of surgical research.

[2]  V. Hancı,et al.  Protective effect of dexmedetomidine in a rat model of α-naphthylthiourea-induced acute lung injury. , 2012, The Journal of surgical research.

[3]  Hao Wang,et al.  Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats. , 2012, Saudi medical journal.

[4]  Shaoyi Chen,et al.  Pentoxifylline and prevention of hyperoxia-induced lung ­injury in neonatal rats , 2012, Pediatric Research.

[5]  H. Zhao,et al.  Dexmedetomidine attenuates remote lung injury induced by renal ischemia‐reperfusion in mice , 2011, Acta anaesthesiologica Scandinavica.

[6]  A. Ghali,et al.  Preanesthetic medication in children: A comparison of intranasal dexmedetomidine versus oral midazolam , 2011, Saudi journal of anaesthesia.

[7]  Sourav Ghosh,et al.  Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery. , 2010, The Ceylon medical journal.

[8]  V. Bhandari.  Hyperoxia-derived lung damage in preterm infants. , 2010, Seminars in fetal & neonatal medicine.

[9]  S. Kurosawa,et al.  Cesarean Section and Primary Pulmonary Hypertension: The Role of Intravenous Dexmedetomidine , 2010 .

[10]  A. Sezer,et al.  The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study. , 2010, Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.

[11]  P. Tsai,et al.  Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats. , 2009, Resuscitation.

[12]  B. Funke,et al.  Central sympatholytics prolong survival in experimental sepsis , 2009, Critical care.

[13]  H. Koçoğlu,et al.  Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Kidney: A Histopathologic Study , 2009, Renal failure.

[14]  P. Tsai,et al.  Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. , 2008, Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists.

[15]  H. Inaba,et al.  Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats , 2008, Journal of Anesthesia.

[16]  T. Horiguchi,et al.  Intravenous Dexmedetomidine Decreases Lung Permeability Induced by Intracranial Hypertension in Rats , 2008, Anesthesia and analgesia.

[17]  V. Bhandari,et al.  Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. , 2006, Free radical biology & medicine.

[18]  Zhi-Ling Yu,et al.  [Protective effects of captopril on hyperoxia-induced lung injury in neonatal rats]. , 2006, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

[19]  Kerri M. Robertson,et al.  Dexmedetomidine Pharmacodynamics: Part I: Crossover Comparison of the Respiratory Effects of Dexmedetomidine and Remifentanil in Healthy Volunteers , 2004, Anesthesiology.

[20]  Y. Takemoto,et al.  Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats , 2004, Critical care medicine.

[21]  W. Doyle,et al.  Awake Craniotomy with Dexmedetomidine in Pediatric Patients , 2003, Journal of neurosurgical anesthesiology.

[22]  R. Venn,et al.  Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. , 2001, British journal of anaesthesia.

[23]  R. Venn,et al.  Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. , 2001, British journal of anaesthesia.

[24]  E. Bancalari,et al.  Bronchopulmonary dysplasia. , 1986, Pediatric clinics of North America.

[25]  A. Verkman,et al.  Role of aquaporin water channels in pleural fluid dynamics. , 2000, American journal of physiology. Cell physiology.

[26]  A. Verkman,et al.  Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice , 2000, The Journal of physiology.

[27]  A. Verkman,et al.  Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. , 1999, The Journal of clinical investigation.

[28]  J. Wispé,et al.  Functional and pathological effects of prolonged hyperoxia in neonatal mice. , 1998, American Journal of Physiology.

[29]  M. Maze,et al.  Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. , 1993, Anesthesiology.

[30]  S. Lee,et al.  Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80 , 1985, The Journal of experimental medicine.

[31]  W. Thurlbeck,et al.  Postnatal growth of the mouse lung. , 1975, Journal of anatomy.