Thermoacoustic tomography with integrating area and line detectors

Thermoacoustic (optoacoustic, photoacoustic) tomography is based on the generation of acoustic waves by illumination of a sample with a short electromagnetic pulse. The absorption density inside the sample is reconstructed from the acoustic pressure measured outside the illuminated sample. So far measurement data have been collected with small detectors as approximations of point detectors. Here, a novel measurement setup applying integrating detectors (e.g., lines or planes made of piezoelectric films) is presented. That way, the pressure is integrated along one or two dimensions, enabling the use of numerically efficient algorithms, such as algorithms for the inverse radon transformation, for thermoacoustic tomography. To reconstruct a three-dimensional sample, either an area detector has to be moved tangential around a sphere that encloses the sample or an array of line detectors is rotated around a single axis. The line detectors can be focused on cross sections perpendicular to the rotation axis using a synthetic aperture (SAFT) or by scanning with a cylindrical lens detector. Measurements were made with piezoelectric polyvinylidene fluoride film detectors and evaluated by comparison with numerical simulations. The resolution achieved in the resulting tomography images is demonstrated on the example of the reconstructed cross section of a grape.

[1]  Massoud Motamedi,et al.  Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study. , 2002, Applied optics.

[2]  Robert A. Kruger,et al.  Thermoacoustic Molecular Imaging of Small Animals , 2003 .

[3]  W. Ertmer,et al.  Optoacoustic imaging for optimization of laser cyclophotocoagulation. , 2003, Journal of biomedical optics.

[4]  H. Weber,et al.  Optoacoustic imaging using a three-dimensional reconstruction algorithm , 2001 .

[5]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[6]  Guenther Paltauf,et al.  Spectral optoacoustic imaging using a wavelength-multiplexing technique , 2004, SPIE BiOS.

[7]  Minghua Xu,et al.  Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[8]  Roy G. M. Kolkman,et al.  In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor , 2003 .

[9]  Rakesh,et al.  Determining a Function from Its Mean Values Over a Family of Spheres , 2004, SIAM J. Math. Anal..

[10]  Pingyu Liu Image reconstruction from photoacoustic pressure signals , 1996, Photonics West.

[11]  Minghua Xu,et al.  Exact frequency-domain reconstruction for thermoacoustic tomography. II. Cylindrical geometry , 2002, IEEE Transactions on Medical Imaging.

[12]  Howard Nathel Laser opto-acoustic imaging: Let there be light that sounds! , 1999 .

[13]  Wiendelt Steenbergen,et al.  Poly(vinyl alcohol) gels for use as tissue phantoms in photoacoustic mammography. , 2003, Physics in medicine and biology.

[14]  K. P. Köstli,et al.  Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response. , 2003, Applied optics.

[15]  Guenther Paltauf Dual-wavelength optoacoustic imaging , 2003, European Conference on Biomedical Optics.

[16]  D. Agard Optical sectioning microscopy: cellular architecture in three dimensions. , 1984, Annual review of biophysics and bioengineering.

[17]  Martin Frenz,et al.  Spectral optoacoustic imaging using a scanning transducer , 2001, European Conference on Biomedical Optics.

[18]  Robert A. Kruger,et al.  Thermoacoustic CT of the breast , 2002, SPIE Medical Imaging.

[19]  F. Natterer The Mathematics of Computerized Tomography , 1986 .

[20]  Minghua Xu,et al.  Time-domain reconstruction for thermoacoustic tomography in a spherical geometry , 2002, IEEE Transactions on Medical Imaging.

[21]  R. Kruger,et al.  Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz-feasibility study. , 2000, Radiology.

[22]  Alexander A. Oraevsky,et al.  Optoacoustic tomography of breast cancer with arc-array transducer , 2000, BiOS.

[23]  Yuan Xu,et al.  Exact frequency-domain reconstruction for thermoacoustic tomography. I. Planar geometry , 2002, IEEE Transactions on Medical Imaging.

[24]  Otmar Scherzer,et al.  Thermoacoustic computed tomography with large planar receivers , 2004 .

[25]  Zhongping Chen,et al.  Clinical testing of a photoacoustic probe for port wine stain depth determination , 2002, Lasers in surgery and medicine.