Antibody to mouse alpha/beta interferon abrogates Pichinde virus-induced liver lesions in suckling mice

Infection of newborn C3HeB/FeJ mice with the arenavirus Pichinde resulted in stunted growth, severe liver cell degeneration, and death. Administration of sheep anti-mouse alpha/beta interferon globulin completely abrogated liver lesions in virus-infected mice, although it did not decrease the incidence of mortality. These results indicate that endogenous interferon may be responsible for some manifestations of viral disease.

[1]  M. Buchmeier,et al.  Perturbation of differentiated functions during viral infection in vivo. I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency. , 1985, Virology.

[2]  J. Maiztegui,et al.  Correlation between endogenous interferon and the clinical evolution of patients with Argentine hemorrhagic fever. , 1985, Journal of interferon research.

[3]  I. Gresser,et al.  Interferon alters the composition and metabolism of lipids in the liver of suckling mice. , 1985, Journal of interferon research.

[4]  J. Maiztegui,et al.  Endogenous interferon in Argentine hemorrhagic fever. , 1984, The Journal of infectious diseases.

[5]  Moses Rodriguez,et al.  Viral perturbation of endocrine function: disordered cell function leads to disturbed homeostasis and disease , 1984, Nature.

[6]  R. Belshe.  Textbook of human virology , 1984 .

[7]  J. McCormick,et al.  Pathologic and virologic study of fatal Lassa fever in man. , 1982, The American journal of pathology.

[8]  D. Woodrow,et al.  Interferon as a cause of endoplasmic reticulum abnormalities within hepatocytes in newborn mice. , 1982, British journal of experimental pathology.

[9]  I. Gresser.  Can interferon induce disease? , 1982, Interferon.

[10]  M. Aguet,et al.  Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice. , 1981, The American journal of pathology.

[11]  P. Verroust,et al.  Severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon , 1980, The Journal of experimental medicine.

[12]  J. Gresser,et al.  Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[13]  I. Gresser,et al.  Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[14]  I. Gresser,et al.  Lethality of interferon preparations for newborn mice , 1975, Nature.

[15]  D. Walker,et al.  The pathology of human Lassa fever. , 1975, Bulletin of the World Health Organization.

[16]  J. Maiztegui,et al.  Pathology of 12 fatal cases of Argentine hemorrhagic fever. , 1973, The American journal of tropical medicine and hygiene.

[17]  O. Wood,et al.  Lassa fever, a new virus disease of man from West Africa. IV. Electron microscopy of Vero cell cultures infected with Lassa virus. , 1970, The American journal of tropical medicine and hygiene.

[18]  K. Johnson,et al.  Bolivian hemorrhagic fever: A report of four cases , 1966 .

[19]  R. Mackenzie,et al.  EPIDEMIC HEMORRHAGIC FEVER IN BOLIVIA. I. A PRELIMINARY REPORT OF THE EPIDEMIOLOGIC AND CLINICAL FINDINGS IN A NEW EPIDEMIC AREA IN SOUTH AMERICA. , 1964, The American journal of tropical medicine and hygiene.