High resolution imaging of acne lesion development and scarring in human facial skin using OCT‐based microangiography

Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography‐based microangiography in detecting high‐resolution, three‐dimensional structural, and microvascular features of in vivo human facial skin during acne lesion initiation and scar development.

[1]  Michelle L. Varney,et al.  IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis1 , 2003, The Journal of Immunology.

[2]  H. Svensson,et al.  Wound healing after total elbow replacement in rheumatoid arthritis. Wound complications in 50 cases and laser-Doppler imaging of skin microcirculation. , 1995, Acta orthopaedica Scandinavica.

[3]  Ruikang K. Wang,et al.  Theory, developments and applications of optical coherence tomography , 2005 .

[4]  Ruikang K. Wang,et al.  Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System , 2012, Int. J. Biomed. Imaging.

[5]  O. Markowitz,et al.  Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment. , 2014, Journal of drugs in dermatology : JDD.

[6]  G. Jemec,et al.  In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20‐MHz ultrasound , 2009, The British journal of dermatology.

[7]  Tokichi Miyakawa,et al.  Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. , 2004, The Journal of investigative dermatology.

[8]  H. S. Abd El All,et al.  Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris , 2007, Diagnostic pathology.

[9]  Xingde Li,et al.  Noninvasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography. , 2006, Journal of biomedical optics.

[10]  Thilo Gambichler,et al.  Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology , 2005, Archives of Dermatological Research.

[11]  Ruikang K. Wang,et al.  Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. , 2010, Optics letters.

[12]  Haishan Zeng,et al.  Does optical microangiography provide accurate imaging of capillary vessels?: validation using multiphoton microscopy , 2014, Journal of biomedical optics.

[13]  Chen D. Lu,et al.  Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers , 2012, Biomedical optics express.

[14]  Ruikang K. Wang,et al.  Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography , 2014, Journal of biomedical optics.

[15]  A. Antonelli,et al.  Systemic sclerosis and cryoglobulinemia: our experience with overlapping syndrome of scleroderma and severe cryoglobulinemic vasculitis and review of the literature. , 2013, Autoimmunity reviews.

[16]  Ruikang K. Wang,et al.  Three dimensional optical angiography. , 2007, Optics express.

[17]  T. King,et al.  Laser doppler imaging--a new technique for quantifying microcirculatory flow in patients with primary Raynaud's phenomenon and systemic sclerosis. , 1999, Microvascular research.

[18]  A. Bayat,et al.  Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin? , 2014, The British journal of dermatology.

[19]  Gangjun Liu,et al.  In vivo, high‐resolution, three‐dimensional imaging of port wine stain microvasculature in human skin , 2013, Lasers in surgery and medicine.

[20]  M. Picardo,et al.  New developments in our understanding of acne pathogenesis and treatment , 2009, Experimental dermatology.

[21]  Ruikang K. Wang,et al.  Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography. , 2006, Optics letters.

[22]  Ruikang K. Wang,et al.  Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. , 2014, Ophthalmic surgery, lasers & imaging retina.

[23]  P Wilson,et al.  Wound healing assessment using 20 MHz ultrasound and photography , 2003, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[24]  Ruikang K. Wang,et al.  Capillary blood flow imaging within human finger cuticle using optical microangiography , 2015, Journal of biophotonics.

[25]  G. Leese,et al.  Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy. , 2002, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[26]  J. Leyden,et al.  Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status report. , 2009, Dermatologic clinics.

[27]  M. Dómine,et al.  Acute and severe acne in a patient treated with bevacizumab , 2013, International journal of dermatology.

[28]  Ruikang K. Wang,et al.  Application of Thinned-Skull Cranial Window to Mouse Cerebral Blood Flow Imaging Using Optical Microangiography , 2014, PloS one.

[29]  Ruikang K. Wang,et al.  In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography , 2011, Lasers in surgery and medicine.

[30]  Ruikang K. Wang,et al.  Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds. , 2010, Optics express.

[31]  R. Kreis,et al.  Confocal laser scanning microscopy of porcine skin: implications for human wound healing studies , 1997, Journal of anatomy.

[32]  Lawrence Charles Parish,et al.  The assessment of acne: an evaluation of grading and lesion counting in the measurement of acne. , 2004, Clinics in dermatology.

[33]  A. Ortiz,et al.  A review of lasers and light sources in the treatment of acne vulgaris , 2005, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[34]  Thilo Gambichler,et al.  In vivo optical coherence tomography of basal cell carcinoma. , 2007, Journal of dermatological science.

[35]  H. Yahya Acne vulgaris in Nigerian adolescents – prevalence, severity, beliefs, perceptions, and practices , 2009, International journal of dermatology.

[36]  E. Papadimitriou,et al.  Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo. , 2013, European journal of pharmacology.

[37]  Utku Baran,et al.  In vivo blood flow imaging of inflammatory human skin induced by tape stripping using optical microangiography , 2015, Journal of biophotonics.

[38]  J. Vincent,et al.  Microcirculatory Alterations in Patients With Severe Sepsis: Impact of Time of Assessment and Relationship With Outcome* , 2013, Critical care medicine.

[39]  Ruikang K. Wang,et al.  High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography. , 2010, Journal of biomedical optics.

[40]  G. Clough Role of nitric oxide in the regulation of microvascular perfusion in human skin in vivo , 1999, The Journal of physiology.

[41]  Ruikang K. Wang,et al.  Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask , 2014, Journal of biomedical optics.

[42]  J. Guy,et al.  Noncontact laser Doppler imaging in burn depth analysis of the extremities. , 2003, The Journal of burn care & rehabilitation.

[43]  Utku Baran,et al.  Motion artifact and background noise suppression on optical microangiography frames using a naïve Bayes mask. , 2014, Applied optics.

[44]  Martin Leahy,et al.  In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT) , 2011, Biomedical optics express.