Magnetic particles in ultrasensitive biomarker protein measurements for cancer detection and monitoring.

IMPORTANCE OF THE FIELD: Devices for the reliable detection of panels of biomarker proteins facilitated by magnetic bead-based technologies have the potential to greatly improve future cancer diagnostics. The reason for this review is to highlight promising research on emerging procedures for protein capture, transport and detection featuring magnetic particles. AREAS COVERED IN THIS REVIEW: The review covers applications of magnetic particles in protein immunoassays in emerging research and commercial methods, and stresses multiplexed protein assays for reliable future cancer diagnostics. Research literature over the past dozen years has been surveyed and specific examples are presented in detail. EXPERT OPINION: Magnetic particles are important components of emerging protein detection systems. They need to be integrated into simple inexpensive systems for accurate, sensitive detection of fully validated panels of biomarker proteins to be widely useful in clinical cancer diagnostics.

[1]  J. Thome,et al.  Serum protein profiling and proteomics in autistic spectrum disorder using magnetic bead-assisted mass spectrometry , 2010, European Archives of Psychiatry and Clinical Neuroscience.

[2]  M. Mascini,et al.  Aptamer-based detection of plasma proteins by an electrochemical assay coupled to magnetic beads. , 2007, Analytical chemistry.

[3]  Gil U. Lee,et al.  A biosensor based on magnetoresistance technology. , 1998, Biosensors & bioelectronics.

[4]  Adarsh Sandhu,et al.  Biosensing: new probes offer much faster results. , 2007, Nature nanotechnology.

[5]  Guodong Liu,et al.  Multiple enzyme layers on carbon nanotubes for electrochemical detection down to 80 DNA copies. , 2005, Analytical chemistry.

[6]  I. Tothill.  Biosensors for cancer markers diagnosis. , 2009, Seminars in cell & developmental biology.

[7]  Chad A. Mirkin,et al.  Drivers of biodiagnostic development , 2009, Nature.

[8]  Jwa-Min Nam,et al.  Colorimetric bio-barcode amplification assay for cytokines. , 2005, Analytical chemistry.

[9]  Dipankar Ghosh,et al.  Electrochemical Immunoassay for Free Prostate Specific Antigen (f-PSA) Using Magnetic Beads , 2008 .

[10]  I. Willner,et al.  Enhancement of Bioelectrocatalytic Processes by the Rotation of Mediator-Functionalized Magnetic Particles on Electrode Surfaces: Comparison with a Rotating Disk Electrode , 2005 .

[11]  Itamar Willner,et al.  Magnetic control of electrocatalytic and bioelectrocatalytic processes. , 2003, Angewandte Chemie.

[12]  Christof M Niemeyer,et al.  Magneto immuno-PCR: a novel immunoassay based on biogenic magnetosome nanoparticles. , 2007, Biochemical and biophysical research communications.

[13]  Jeffrey R. Whiteaker,et al.  Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers. , 2007, Analytical biochemistry.

[14]  C. Mirkin,et al.  Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Joseph Wang.  Nanomaterial-based electrochemical biosensors. , 2005, The Analyst.

[16]  L. Cazares,et al.  Differential Capture of Serum Proteins for Expression Profiling and Biomarker Discovery in Pre‐ and Posttreatment Head and Neck Cancer Samples , 2008, The Laryngoscope.

[17]  Wei Zhan,et al.  Electrogenerated chemiluminescence. 83. Immunoassay of human C-reactive protein by using Ru(bpy)3(2+)-encapsulated liposomes as labels. , 2007, Analytical chemistry.

[18]  Arben Merkoçi,et al.  Electrochemical detection of proteins using nanoparticles: applications to diagnostics. , 2010, Expert opinion on medical diagnostics.

[19]  Chad A Mirkin,et al.  Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes. , 2006, Journal of the American Chemical Society.

[20]  Boris Murmann,et al.  Matrix-insensitive protein assays push the limits of biosensors in medicine , 2009, Nature Medicine.

[21]  J. Llandro,et al.  Magnetic biosensor technologies for medical applications: a review , 2010, Medical & Biological Engineering & Computing.

[22]  C. Mirkin,et al.  Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins , 2003, Science.

[23]  Giovanna Marrazza,et al.  A New Electrochemical Multiplexed Assay for PSA Cancer Marker Detection , 2011 .

[24]  E. Capoluongo,et al.  Assessment of parathyroid function in clinical practice: which parathyroid hormone assay is better? , 2004, Clinical chemistry.

[25]  Liesbet Lagae,et al.  Magnetic bead sensing platform for the detection of proteins. , 2007, Analytical chemistry.

[26]  Osamu Suzuki,et al.  Highly Sensitive Electrochemiluminescence Immunoassay Using the Ruthenium Chelate-Labeled Antibody Bound on the Magnetic Micro Beads , 1999 .

[27]  Haesik Yang,et al.  Ultrasensitive electrochemical immunosensing using magnetic beads and gold nanocatalysts. , 2008, Biosensors & bioelectronics.

[28]  Ruo Yuan,et al.  Magnetic control of an electrochemical microfluidic device with an arrayed immunosensor for simultaneous multiple immunoassays. , 2007, Clinical chemistry.

[29]  Arben Merkoçi,et al.  Double-codified gold nanolabels for enhanced immunoanalysis. , 2007, Analytical chemistry.

[30]  T. Tanaka,et al.  Biological Immunoassays Without Bound/Free Separation Utilizing Magnetic Marker and HTS SQUID , 2007, IEEE Transactions on Applied Superconductivity.

[31]  D. DeMets,et al.  Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework , 2001, Clinical pharmacology and therapeutics.

[32]  C. Franzini,et al.  Plasma or serum samples: measurements of cardiac troponin T and of other analytes compared , 2004, Clinical chemistry and laboratory medicine.

[33]  A. Helmicki,et al.  An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities. , 2002, Lab on a chip.

[34]  Robert L White,et al.  Multiplex protein assays based on real-time magnetic nanotag sensing , 2008, Proceedings of the National Academy of Sciences.

[35]  M. Mascini,et al.  Detection of C Reactive Protein (CRP) in Serum by an Electrochemical Aptamer‐Based Sandwich Assay , 2009 .

[36]  Elisabeth Verpoorte,et al.  Beads and chips: new recipes for analysis. , 2003, Lab on a chip.

[37]  J. Weinstein,et al.  Biomarkers in Cancer Staging, Prognosis and Treatment Selection , 2005, Nature Reviews Cancer.

[38]  Kyung-Jin Jang,et al.  Detection of proteins using a colorimetric bio-barcode assay , 2007, Nature Protocols.

[39]  Yi Xiao,et al.  Detection of proteins in serum by micromagnetic aptamer PCR (MAP) technology. , 2010, Angewandte Chemie.

[40]  W. Heineman,et al.  Microbead-based electrochemical immunoassay with interdigitated array electrodes. , 2004, Analytical Biochemistry.

[41]  James F Rusling,et al.  Attomolar detection of a cancer biomarker protein in serum by surface plasmon resonance using superparamagnetic particle labels. , 2011, Angewandte Chemie.

[42]  Guodong Liu,et al.  DNA-based amplified bioelectronic detection and coding of proteins. , 2004, Angewandte Chemie.

[43]  L. Whitman,et al.  Rapid, femtomolar bioassays in complex matrices combining microfluidics and magnetoelectronics. , 2007, Biosensors & bioelectronics.

[44]  James F Rusling,et al.  Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. , 2009, ACS nano.

[45]  Xiaoli Zhang,et al.  Ultrasensitive Eletrogenerated Chemiluminescence Immunoassay by Magnetic Nanobead Amplification , 2010 .

[46]  Joseph Wang,et al.  Ultrasensitive electrical biosensing of proteins and DNA: carbon-nanotube derived amplification of the recognition and transduction events. , 2004, Journal of the American Chemical Society.

[47]  A. Bard,et al.  Electrogenerated chemiluminescence. 80. C-reactive protein determination at high amplification with [Ru(bpy)3]2+-containing microspheres. , 2004, Analytical chemistry.

[48]  Yusuke Arima,et al.  Surface plasmon resonance-based highly sensitive immunosensing for brain natriuretic peptide using nanobeads for signal amplification. , 2006, Analytical biochemistry.

[49]  D. Chan,et al.  Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. , 2002, Clinical chemistry.

[50]  L. Whitman,et al.  Magnetic labeling, detection, and system integration. , 2008, Biosensors & bioelectronics.

[51]  E. Anckaert,et al.  Multicenter evaluation of a rapid electrochemiluminescent adrenocorticotropic hormone (ACTH) immunoassay. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[52]  Sudhir Srivastava,et al.  Keynote review: Recent advances in biomarkers for cancer diagnosis and treatment , 2005 .

[53]  Michael Keusgen,et al.  CRP determination based on a novel magnetic biosensor. , 2007, Biosensors & bioelectronics.

[54]  Jason Y. Park,et al.  Magnetism and magnetoresistance: attractive prospects for point-of-care testing? , 2009, Clinical chemistry.

[55]  Joon Won Park,et al.  Nanotechnology for Early Cancer Detection , 2010, Sensors.

[56]  Mukesh Verma,et al.  Challenges for Biomarkers in Cancer Detection , 2004, Annals of the New York Academy of Sciences.

[57]  B. Boser,et al.  A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. , 2006, Journal of immunological methods.

[58]  A M Ward,et al.  Prostate specific antigen: biology, biochemistry and available commercial assays , 2001, Annals of clinical biochemistry.

[59]  M. Girolami,et al.  Recommendations for Biomarker Identification and Qualification in Clinical Proteomics , 2010, Science Translational Medicine.

[60]  S. Hanash,et al.  Emerging molecular biomarkers—blood-based strategies to detect and monitor cancer , 2011, Nature Reviews Clinical Oncology.

[61]  F. Goodsaid,et al.  Translational Medicine and the Value of Biomarker Qualification , 2010, Science Translational Medicine.

[62]  J. Rusling,et al.  Electrochemiluminescent immunosensor for detection of protein cancer biomarkers using carbon nanotube forests and [Ru-(bpy)(3)](2+)-doped silica nanoparticles. , 2009, Chemical communications.

[63]  Ruo Yuan,et al.  Ultrasensitive electrochemical immunosensor for clinical immunoassay using thionine-doped magnetic gold nanospheres as labels and horseradish peroxidase as enhancer. , 2008, Analytical chemistry.

[64]  M. Meyerhoff,et al.  Gold-coated magnetic particles for solid-phase immunoassays: enhancing immobilized antibody binding efficiency and analytical performance. , 2006, Analytical chemistry.

[65]  A. Limaye,et al.  Surface plasmon resonance detection using antibody-linked magnetic nanoparticles for analyte capture, purification, concentration, and signal amplification. , 2009, Analytical chemistry.

[66]  H. Tsai,et al.  Detection of C-reactive protein based on immunoassay using antibody-conjugated magnetic nanoparticles. , 2007, Analytical chemistry.

[67]  Martin A M Gijs,et al.  Microfluidic applications of magnetic particles for biological analysis and catalysis. , 2010, Chemical reviews.

[68]  Matthias Franzreb,et al.  Protein purification using magnetic adsorbent particles , 2006, Applied Microbiology and Biotechnology.

[69]  James F Rusling,et al.  Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. , 2011, Biosensors & bioelectronics.

[70]  Daniel L Graham,et al.  Magnetoresistive-based biosensors and biochips. , 2004, Trends in biotechnology.

[71]  Guodong Liu,et al.  Electrochemical coding for multiplexed immunoassays of proteins. , 2004, Analytical chemistry.

[72]  S. Hanash,et al.  Mining the plasma proteome for cancer biomarkers , 2008, Nature.

[73]  M. Hill,et al.  Lectin magnetic bead array for biomarker discovery. , 2010, Journal of proteome research.

[74]  James F Rusling,et al.  Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. , 2010, The Analyst.

[75]  E. Diamandis,et al.  Strategies for discovering novel cancer biomarkers through utilization of emerging technologies , 2008, Nature Clinical Practice Oncology.

[76]  Cheryl Moody Bartel,et al.  On-chip aptamer-based sandwich assay for thrombin detection employing magnetic beads and quantum dots. , 2010, Analytical chemistry.