Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway.

[1]  Ye Zhang,et al.  β‐Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin‐1 signaling , 2019, Phytotherapy research : PTR.

[2]  Ye Zhang,et al.  Leucine‐rich repeat neuronal protein‐1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL , 2019, Cancer science.

[3]  W. Jin,et al.  G-protein-signaling modulator 2 expression and role in a CD133+ pancreatic cancer stem cell subset , 2019, OncoTargets and therapy.

[4]  I. Dagogo-Jack,et al.  Targeting oncogenic drivers in lung cancer: Recent progress, current challenges and future opportunities , 2019, Pharmacology & therapeutics.

[5]  R. Roskoski.  Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers. , 2019, Pharmacological research.

[6]  Zhe Zhang,et al.  Limb-Bud and Heart Attenuates Growth and Invasion of Human Lung Adenocarcinoma Cells and Predicts Survival Outcome , 2018, Cellular Physiology and Biochemistry.

[7]  Ramón Rami-Porta,et al.  Lung cancer staging: a concise update , 2018, European Respiratory Journal.

[8]  Adam Round,et al.  Insc:LGN tetramers promote asymmetric divisions of mammary stem cells , 2018, Nature Communications.

[9]  C. Lovly,et al.  Mechanisms of receptor tyrosine kinase activation in cancer , 2018, Molecular Cancer.

[10]  Caroline Dive,et al.  Progress and prospects of early detection in lung cancer , 2017, Open Biology.

[11]  Meryem Köse.  GPCRs and EGFR - Cross-talk of membrane receptors in cancer. , 2017, Bioorganic & medicinal chemistry letters.

[12]  Ximing Xu,et al.  High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[13]  Walter J Curran,et al.  Lung cancer: current therapies and new targeted treatments , 2017, The Lancet.

[14]  I. So,et al.  Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o. , 2016, The Biochemical journal.

[15]  Zhixiang Wang.  Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research , 2016, International journal of molecular sciences.

[16]  M. Mapelli,et al.  Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation , 2015, Nature Structural &Molecular Biology.

[17]  M. Tekin,et al.  Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss , 2015, PloS one.

[18]  Steven J. M. Jones,et al.  GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. , 2012, American journal of human genetics.

[19]  I. Cheeseman,et al.  Chromosome and spindle pole-derived signals generate an intrinsic code for spindle position and orientation , 2012, Nature Cell Biology.

[20]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[21]  Yusuke Nakamura,et al.  Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells , 2010, Genes, chromosomes & cancer.

[22]  Tom Walsh,et al.  Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. , 2010, American journal of human genetics.

[23]  T. Miki,et al.  Ric-8A and Giα Recruit LGN, NuMA, and Dynein to the Cell Cortex To Help Orient the Mitotic Spindle , 2010, Molecular and Cellular Biology.

[24]  T. Gettys,et al.  The G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and Gialpha3 influence cortical positioning of the mitotic spindle poles at metaphase in symmetrically dividing mammalian cells. , 2006, European journal of cell biology.

[25]  Christopher R. McCudden,et al.  Gα selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN , 2005 .

[26]  Y. Takai,et al.  Direct Binding of Lgl2 to LGN during Mitosis and Its Requirement for Normal Cell Division* , 2005, Journal of Biological Chemistry.

[27]  I. Macara,et al.  A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization , 2001, Nature Cell Biology.

[28]  P. Insel,et al.  Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. , 1996, Gene.