Chapter 15 – Design of Reactors and Mixers

How to select and size a reactor. Factors to consider in optimizing reaction conditions: temperature, pressure, solvents, concentrations, catalyst, etc. How to design static mixers and mixing vessels. How to design reactors for heating, cooling, and catalysis. How to design reactors for multiphase reactions. How to design reactors for biological processes. How to design stirred tank reactors, packed bed reactors, fluidized bed reactors and fermenters. Factors to consider in scaling up reactions from the laboratory to plant scale.

[1]  Sidney H. Willig,et al.  Good manufacturing practices for pharmaceuticals: A plan for total quality control , 2000 .

[2]  K. Riet,et al.  Review of Measuring Methods and Results in Nonviscous Gas-Liquid Mass Transfer in Stirred Vessels , 1979 .

[3]  C. Wilke,et al.  Correlation of diffusion coefficients in dilute solutions , 1955 .

[4]  Stanley S. Grossel Inherently safer chemical processes: A life cycle approach, 2nd edition (2009) , 2009 .

[5]  Warren E. Stewart,et al.  Computer-Aided Modeling of Reactive Systems , 2008 .

[6]  John R. Grace,et al.  Circulating fluidized beds , 1996 .

[7]  H. D. Zughbi,et al.  Mixing in Pipelines with Side and Opposed Tees , 2003 .

[8]  Vincent W. Uhl,et al.  Mixing: Theory and Practice , 1986 .

[9]  D. Golden,et al.  Additivity rules for the estimation of thermochemical properties , 1969 .

[10]  Daniel A. Crowl,et al.  Chemical Process Safety: Fundamentals with Applications , 2001 .

[11]  Howard F. Rase,et al.  Chemical Reactor Design for Process Plants , 1977 .

[12]  Donald W. Breck,et al.  Zeolite Molecular Sieves: Structure, Chemistry, and Use , 1974 .

[13]  E. Nauman Chemical Reactor Design , 1987 .

[14]  L. M. Rose,et al.  Chemical reactor design in practice , 1981 .

[15]  Michael Levin,et al.  Pharmaceutical process scale-up , 2001 .

[16]  N. Frossling,et al.  Uber die Verdunstung fallender Tropfen , 1938 .

[17]  Robert S. Brodkey,et al.  Turbulent motion and mixing in a pipe , 1964 .

[18]  Kamil Wichterle,et al.  Heat transfer in agitated vessels , 1994 .

[19]  G. A. Melhem Designing Emergency Relief Devices for Reactive Systems , 2005 .

[20]  J. Kubíková,et al.  Vitamin losses: Retention during heat treatment and continual changes expressed by mathematical models , 2006 .

[21]  Richard A. Greenberg,et al.  Statistics and Experimental Design , 1970, The Yale Journal of Biology and Medicine.

[22]  L. Doraiswamy,et al.  Heterogeneous reactions: Analysis examples and reactor design. Vol. 1: Gas solid and solid-solid reactions , 1984 .

[23]  George Thodos,et al.  Direct analogy between mass and heat transfer to beds of spheres , 1963 .

[24]  J. M. Smith Chemical Engineering Kinetics , 1980 .

[25]  Donald F. Othmer,et al.  Fluidization and fluid-particle systems , 1960 .

[26]  Thomas Post,et al.  Understand the Real World of Mixing , 2010 .

[27]  P. Basu Combustion and gasification in fluidized beds , 2006 .

[28]  Peter Harriott,et al.  Unit Operations of Chemical Engineering , 2004 .

[29]  H. Fossett,et al.  The Application of Free Jets to the Mixing of Fluids in Bulk , 1949 .

[30]  E. S. Domalski Selected Values of Heats of Combustion and Heats of Formation of Organic Compounds Containing the Elements C, H, N, O, P, and S. , 1972 .

[31]  Wei Liu,et al.  Engineering of an elastic large muscular vessel wall with pulsatile stimulation in bioreactor. , 2008, Biomaterials.

[32]  R. Langer,et al.  Tissue engineering: current state and perspectives , 2004, Applied Microbiology and Biotechnology.

[33]  David F. Ollis,et al.  Biochemical Engineering Fundamentals , 1976 .

[34]  Klaus‐Dieter Henkel Reactor Types and Their Industrial Applications , 2000 .

[35]  Ann Thayer OUTFITTING THE FULL DISPOSABLE KIT: Providers of SINGLE-USE BIOREACTORS seek to expand flexibility while keeping costs low , 2010 .

[36]  S. Nagata,et al.  Power Characteristics of Mixing Impellers , 1956 .

[37]  Patrick Vermette,et al.  Bioreactors for tissue mass culture: design, characterization, and recent advances. , 2005, Biomaterials.

[38]  H. K. Fauske,et al.  Properly Size Vents for Nonreactive and Reactive Chemicals , 2000 .

[39]  S. Ergun Fluid flow through packed columns , 1952 .

[40]  Octave Levenspiel,et al.  The chemical reactor minibook , 1979 .

[41]  Milorad P. Dudukovic,et al.  Pressure drop and liquid holdup in high pressure trickle-bed reactors , 1994 .

[42]  Santi Kulprathipanja,et al.  Zeolites in industrial separation and catalysis , 2010 .

[43]  E. L. Paul,et al.  Handbook of Industrial Mixing: Science and Practice , 2003 .

[44]  Gary B. Tatterson,et al.  Fluid mixing and gas dispersion in agitated tanks , 1991 .

[45]  Paul N. Sharratt Handbook of Batch Process Design , 1997 .

[46]  Rutherford Aris,et al.  Elementary Chemical Reactor Analysis , 1969 .