Drug interactions between inhaled corticosteroids and enzymatic inhibitors

concomitantly treated with an enzymatic inhibitor: itraconazole (six cases), ritonavir (five cases), verapamil (two cases), and diltiazem (two cases). In adults, mean daily dose was lower in cases where a drug interaction was suspected [2,277 µg beclomethasone equivalent (BE) vs. 2,883 µg BE in cases where no drug interaction was suspected; data not shown]. The delay for diagnosis ranged from less than 1 month to 16 months after initiation of the enzymatic inhibitor treatment.

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