Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous epithelial stem cell proliferation
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J. McGrath | D. Rifkin | Raphael Ruppert | R. Fässler | S. Ussar | R. Böttcher | M. Jakobson | J. Lai-Cheong | E. Rognoni | M. Widmaier | Despoina Katsougkri
[1] E. Fuchs,et al. RNAi screens in mice identify physiological regulators of oncogenic growth , 2013, Nature.
[2] Wei-Guo Zhu,et al. Kindlin 2 forms a transcriptional complex with β‐catenin and TCF4 to enhance Wnt signalling , 2012, EMBO reports.
[3] R. Fässler,et al. Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail , 2012, Nature Cell Biology.
[4] G. Rothschild,et al. Functional differences between kindlin-1 and kindlin-2 in keratinocytes , 2012, Journal of Cell Science.
[5] H. Larjava,et al. Integrin β6-deficient mice show enhanced keratinocyte proliferation and retarded hair follicle regression after depilation. , 2012, The Journal of investigative dermatology.
[6] Fiona M. Watt,et al. Epithelial stem cells, wound healing and cancer , 2012, Nature Reviews Cancer.
[7] E. Fuchs,et al. Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. , 2012, Cell stem cell.
[8] F. Lallemand,et al. Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. , 2011, Journal of the National Cancer Institute.
[9] A. Oro,et al. SnapShot: Hair Follicle Stem Cells , 2011, Cell.
[10] R. Bhatia,et al. Stem Cell Quiescence , 2011, Clinical Cancer Research.
[11] Clara L Santos-Cuevas,et al. Multimeric system of 99mTc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor α(v)β(3) expression. , 2011, Bioconjugate chemistry.
[12] Fiona M Watt,et al. Cell-extracellular matrix interactions in normal and diseased skin. , 2011, Cold Spring Harbor perspectives in biology.
[13] C. Has,et al. Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification. , 2011, The American journal of pathology.
[14] F. Watt,et al. The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche , 2011, Cell.
[15] M. Kasper,et al. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes , 2011, Proceedings of the National Academy of Sciences.
[16] F. Watt,et al. Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis , 2010, Nature Protocols.
[17] C. Kunder,et al. Mast cell–derived particles deliver peripheral signals to remote lymph nodes , 2009, The Journal of experimental medicine.
[18] P. Howe,et al. The tale of transforming growth factor‐beta (TGFβ) signaling: A soigné enigma , 2009, IUBMB life.
[19] Marc W. Kirschner,et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.
[20] K. Gottschalk,et al. The Kindlin protein family: new members to the club of focal adhesion proteins. , 2009, Trends in cell biology.
[21] J. McGrath,et al. Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation. , 2009, The American journal of pathology.
[22] K. Kiguchi,et al. Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications , 2009, Nature Protocols.
[23] F. Watt,et al. Epidermal stem cell diversity and quiescence , 2009, EMBO molecular medicine.
[24] Boris Jerchow,et al. Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates , 2009, Nature Genetics.
[25] Michaela Frye,et al. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis , 2009, Cell stem cell.
[26] F. Watt,et al. An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors. , 2009, Cancer research.
[27] J. McGrath,et al. Kindler syndrome: a focal adhesion genodermatosis , 2009, The British journal of dermatology.
[28] Lawrence Lum,et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer , 2008, Nature chemical biology.
[29] R. Fässler,et al. Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction , 2008, PLoS genetics.
[30] J. McGrath,et al. Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. , 2008, The Journal of investigative dermatology.
[31] R. Fässler,et al. Kindlin-2 controls bidirectional signaling of integrins. , 2008, Genes & development.
[32] B. Nieswandt,et al. Kindlin-3 is essential for integrin activation and platelet aggregation , 2008, Nature Medicine.
[33] E. Vilain,et al. Wnt4 inhibits β‐catenin/TCF signalling by redirecting β‐catenin to the cell membrane , 2008 .
[34] J. McGrath,et al. Unusual molecular findings in Kindler syndrome , 2007, The British journal of dermatology.
[35] Joachim P Spatz,et al. Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces. , 2007, Biomaterials.
[36] E. Fuchs,et al. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. , 2007, Cancer cell.
[37] E. Fuchs,et al. Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling , 2007, Proceedings of the National Academy of Sciences.
[38] R. Fässler,et al. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis , 2007, The Journal of cell biology.
[39] R. Phelps,et al. Aggressive squamous cell carcinoma in Kindler syndrome. , 2006, Skinmed.
[40] Xi C. He,et al. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion , 2006, Stem cells.
[41] Fiona M Watt,et al. Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis , 2006 .
[42] Hao-Ven Wang,et al. The Kindlins: subcellular localization and expression during murine development. , 2006, Experimental cell research.
[43] H. Miller,et al. Integrin-αvβ6, a Putative Receptor for Foot-and-Mouth Disease Virus, Is Constitutively Expressed in Ruminant Airways , 2006 .
[44] R. Nusse,et al. Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context , 2006, PLoS biology.
[45] F. Watt,et al. New roles for integrins in squamous-cell carcinoma , 2006, Nature Reviews Cancer.
[46] F. Watt,et al. Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. , 2005, Developmental cell.
[47] Elaine Fuchs,et al. Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. , 2005, Genes & development.
[48] Vikram Devgan,et al. p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. , 2005, Genes & development.
[49] W. Muller,et al. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. , 2004, Cancer cell.
[50] D. Rifkin,et al. Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 , 2004, The Journal of cell biology.
[51] M. Vidal,et al. A keratin K5Cre transgenic line appropriate for tissue‐specific or generalized cre‐mediated recombination , 2004, Genesis.
[52] F. Watt,et al. Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours , 2004, Development.
[53] E. Fuchs,et al. Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.
[54] John P. Sundberg,et al. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis , 2003, Development.
[55] David Boettiger,et al. A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. , 2003, Molecular biology of the cell.
[56] Elaine Fuchs,et al. Stem cells of the skin epithelium , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[57] T. Sun,et al. Hair follicle stem cells. , 2003, The journal of investigative dermatology. Symposium proceedings.
[58] E. Fuchs,et al. Stem cells in the skin: waste not, Wnt not. , 2003, Genes & development.
[59] F. Watt,et al. A tumor-associated β1 integrin mutation that abrogates epithelial differentiation control , 2003, The Journal of cell biology.
[60] Justin P. Annes,et al. Making sense of latent TGFβ activation , 2003, Journal of Cell Science.
[61] F. Watt,et al. Role of integrins in regulating epidermal adhesion, growth and differentiation , 2002, The EMBO journal.
[62] R Paus,et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. , 2001, The Journal of investigative dermatology.
[63] R. Timpl,et al. Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes , 2000, The EMBO journal.
[64] E. Fuchs,et al. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. , 1999, Development.
[65] R Paus,et al. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. , 1999, The Journal of investigative dermatology.
[66] N. Kaminski,et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.
[67] N. Kaminski,et al. A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1 , 1999, Cell.
[68] E. Fuchs,et al. De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin , 1998, Cell.
[69] J. Sundberg,et al. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen , 1997, Molecular carcinogenesis.
[70] R. Fässler,et al. Consequences of lack of beta 1 integrin gene expression in mice. , 1995, Genes & development.
[71] E. Fuchs,et al. Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. , 1995, Genes & development.
[72] C. Herz,et al. Epithelial and Mesenchymal Cell Biology Kindlin-1 Is Required for RhoGTPase-Mediated Lamellipodia Formation in Keratinocytes , 2010 .
[73] J. Golden,et al. Kindlin-2 is required for myocyte elongation and is essential for myogenesis , 2008 .
[74] R. Fässler,et al. Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. , 2007, Methods in enzymology.
[75] N. Kaminski,et al. The Integrin avb6 Binds and Activates Latent TGFb1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis , 1999 .
[76] J. Munger. The integrin αvβ6 binds and activates latent TGFβ1 : A mechanism for regulating pulmonary inflammation and fibrosis , 1999 .
[77] S. Sikdar,et al. Fundamentals and applications , 1998 .