A musculotendon model of the fatigue profiles of paralyzed quadriceps muscle under FES

A musculotendon model of the quadriceps muscle of the activated leg of a paraplegic patient incorporating fatigue was developed. The right quadriceps of a paraplegic patient who was engaged in a functional electrical stimulation (FES) training program was used for the measurements. The muscle studied was considered trained, both relating to strength and fatigue resistance. Extended stimulation was applied with an adjustable electrical stimulator, providing monophasic rectangular pulse trains with a frequency of 20 Hz, pulse width of 0.2 ms, and an intensity of up to 220 mA. The intensity used corresponded to the intensity required for the tested patient to stand up. This intensity was selected to deliberately encourage fatigue, and the result was a gradual and steady decay of the muscle force due to fatigue. The model was able to predict the decaying force during continuous electrical stimulation, as well as to indicate the muscle parameters which yield the best fit between the model prediction and the previously obtained experimental force profiles.<<ETX>>

[1]  A. Hill The heat of shortening and the dynamic constants of muscle , 1938 .

[2]  R. Ramsey,et al.  The isometric length‐tension diagram of isolated skeletal muscle fibers of the frog , 1940 .

[3]  X. Aubert,et al.  The tension-length diagram of the frog's sartorius muscle. , 1951, Archives internationales de physiologie.

[4]  F. Buchthal,et al.  The rheology of the cross striated muscle fibre, with particular reference to isotonic conditions , 1951 .

[5]  S. Walker,et al.  Potentiation and hysteresis induced by stretch and subsequent release of papillary muscle of the dog. , 1960, The American journal of physiology.

[6]  R. Woledge,et al.  The thermoelastic effect of change of tension in active muscle , 1961, The Journal of physiology.

[7]  R. S. Alexander,et al.  MUSCLE STRETCH AND THEORIES OF CONTRACTION. , 1965, The American journal of physiology.

[8]  C. Gans,et al.  The functional significance of muscle architecture--a theoretical analysis. , 1965, Ergebnisse der Anatomie und Entwicklungsgeschichte.

[9]  A. Huxley,et al.  The variation in isometric tension with sarcomere length in vertebrate muscle fibres , 1966, The Journal of physiology.

[10]  A. Bahler,et al.  Series elastic component of mammalian skeletal muscle. , 1967, The American journal of physiology.

[11]  J. B. Reswick,et al.  Electrical Activation of Skeletal Muscle by Sequential Stimulation , 1970 .

[12]  Y C Fung,et al.  Mathematical representation of the mechanical properties of the heart muscle. , 1970, Journal of biomechanics.

[13]  A. Huxley,et al.  Proposed Mechanism of Force Generation in Striated Muscle , 1971, Nature.

[14]  R. Close Dynamic properties of mammalian skeletal muscles. , 1972, Physiological reviews.

[15]  P H Peckham,et al.  Physiologic and metabolic changes in white muscle of cat following induced exercise. , 1973, Brain research.

[16]  E. Marsolais,et al.  Alteration in the force and fatigability of skeletal muscle in quadriplegic humans following exercise induced by chronic electrical stimulation. , 1976, Clinical orthopaedics and related research.

[17]  T L Munsat,et al.  Effects of nerve stimulation on human muscle. , 1976, Archives of neurology.

[18]  S. Salmons,et al.  Significance of impulse activity in the transformation of skeletal muscle type , 1976, Nature.

[19]  David E. Hardt,et al.  Determining Muscle Forces in the Leg During Normal Human Walking—An Application and Evaluation of Optimization Methods , 1978 .

[20]  D. Rushton,et al.  Electrical splinting of the knee in paraplegia , 1979, Paraplegia.

[21]  R. Crowninshield,et al.  THE PREDICTION OF FORCES IN JOINT STRUCTURES: DISTRIBUTION OF INTERSEGMENTAL RESULTANTS , 1981, Exercise and sport sciences reviews.

[22]  R. Crowninshield,et al.  A physiologically based criterion of muscle force prediction in locomotion. , 1981, Journal of biomechanics.

[23]  R. L. Linscheid,et al.  Muscles across the elbow joint: a biomechanical analysis. , 1981, Journal of biomechanics.

[24]  D. A. Williams,et al.  Effects of sarcomere length on the force—pCa relation in fast‐ and slow‐twitch skinned muscle fibres from the rat , 1982, The Journal of physiology.

[25]  P. Rack,et al.  Elastic properties of the cat soleus tendon and their functional importance. , 1984, The Journal of physiology.

[26]  R. Maughan,et al.  Muscle strength and cross-sectional area in man: a comparison of strength-trained and untrained subjects. , 1984, British journal of sports medicine.

[27]  B. Hillen,et al.  Cross-sectional areas and estimated intrinsic strength of the human jaw muscles. , 1985, Acta morphologica Neerlando-Scandinavica.

[28]  D F Rochester,et al.  Contractile properties of intercostal muscles and their functional significance. , 1985, Journal of applied physiology.

[29]  F. E. Zajac,et al.  A Dimensionless musculotendon model , 1985 .

[30]  T. Bajd,et al.  Posture switching for prolonging functional electrical stimulation standing in paraplegic patients , 1986, Paraplegia.

[31]  J Mizrahi,et al.  Recruitment, force and fatigue characteristics of quadriceps muscles of paraplegics isometrically activated by surface functional electrical stimulation. , 1990, Journal of biomedical engineering.

[32]  Y. Itzchak,et al.  In vivo 31P NMR studies of paraplegics' muscles activated by functional electrical stimulation , 1993, Magnetic resonance in medicine.