The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies

A new theory about the development of autoimmunity has emerged from a surprising and disparate set of observations. The elements include antibodies that recognize antibodies, and a peculiar structural relationship between a sense- and antisense-encoded protein (pages 72–79).

[1]  C. Kallenberg,et al.  Association of Chronic Nasal Carriage of Staphylococcus aureus and Higher Relapse Rates in Wegener Granulomatosis , 1994, Annals of Internal Medicine.

[2]  A. Tropsha,et al.  Autoimmunity is triggered by cPR-3(105–201), a protein complementary to human autoantigen proteinase-3 , 2004, Nature Medicine.

[3]  Y. Shoenfeld.  Idiotypic induction of autoimmunity: a new aspect of the idiotypic network , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  D. Isenberg,et al.  The mosaic of autoimmunity. , 1989, Immunology today.

[5]  Y. Shoenfeld,et al.  Common infections, idiotypic dysregulation, autoantibody spread and induction of autoimmune diseases. , 1996, Journal of autoimmunity.

[6]  B. Diamond,et al.  Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype. , 1991, The Journal of clinical investigation.

[7]  A. Meshorer,et al.  Peptides based on the complementarity-determining regions of a pathogenic autoantibody mitigate lupus manifestations of (NZB x NZW)F1 mice via active suppression. , 2003, International immunology.

[8]  A. Meshorer,et al.  Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[9]  P. Fishman,et al.  Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). , 1992, The Journal of clinical investigation.

[10]  L. Rauova,et al.  Efficacy of IVIG affinity-purified anti-double-stranded DNA anti-idiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus. , 2002, International immunology.