Dynamics in the p38alpha MAP kinase-SB203580 complex observed by liquid-state NMR spectroscopy.

[1]  Ad Bax,et al.  Prediction of Sterically Induced Alignment in a Dilute Liquid Crystalline Phase: Aid to Protein Structure Determination by NMR , 2000 .

[2]  S. Grzesiek,et al.  NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.

[3]  Michelle Browner,et al.  Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase. , 2003, Journal of medicinal chemistry.

[4]  D. Zaller,et al.  Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. , 2003 .

[5]  G. Bemis,et al.  The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. , 1997, Chemistry & biology.

[6]  A. Bax,et al.  Evaluation of cross-correlation effects and measurement of one-bond couplings in proteins with short transverse relaxation times. , 2000, Journal of magnetic resonance.

[7]  L. Tong,et al.  Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site , 2002, Nature Structural Biology.

[8]  Philip R. Cohen,et al.  SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1 , 1995, FEBS letters.

[9]  D. Zaller,et al.  Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity , 2003, Nature Structural Biology.

[10]  F. Richards,et al.  NMR sequential assignment of Escherichia coli thioredoxin utilizing random fractional deuteriation. , 1988, Biochemistry.

[11]  E. Goldsmith,et al.  The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Jerry L. Adams,et al.  A protein kinase involved in the regulation of inflammatory cytokine biosynthesis , 1994, Nature.

[13]  G. Zaman,et al.  Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors. , 2006, Assay and drug development technologies.

[14]  E. Springman,et al.  A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase. , 2004, Analytical biochemistry.

[15]  Harald Schwalbe,et al.  NMR characterization of kinase p38 dynamics in free and ligand-bound forms. , 2006, Angewandte Chemie.

[16]  T. Langer,et al.  Charakterisierung der Dynamik der Kinase p38 in freiem und ligandgebundenem Zustand durch NMR‐Spektroskopie , 2006 .

[17]  K. Saxena,et al.  NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38 , 2005, Journal of biomolecular NMR.

[18]  E. Springman,et al.  Improved expression, purification, and crystallization of p38α MAP kinase , 2004 .

[19]  E. Goldsmith,et al.  Structural basis of inhibitor selectivity in MAP kinases. , 1998, Structure.