miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma
暂无分享,去创建一个
C. Bult | F. Slack | K. Politi | D. Costa | J. Asara | Kin-hoe Chow | Tanvi Saxena | He Huang | Wen Cai Zhang | M. Melnick | J. Wells | Min Yuan
[1] Jiandong Shi,et al. Deep RNA Sequencing Reveals a Repertoire of Human Fibroblast Circular RNAs Associated with Cellular Responses to Herpes Simplex Virus 1 Infection , 2018, Cellular Physiology and Biochemistry.
[2] R. Luan,et al. MicroRNA-574 enhances doxorubicin resistance through down-regulating SMAD4 in breast cancer cells. , 2018, European review for medical and pharmacological sciences.
[3] Ying Cheng,et al. Osimertinib in Untreated EGFR‐Mutated Advanced Non–Small‐Cell Lung Cancer , 2018, The New England journal of medicine.
[4] Carol J Bult,et al. The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer. , 2017, Cancer research.
[5] D. Sabatini,et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis , 2017, Nature.
[6] Lili Han,et al. Maternally Expressed Gene 3 (MEG3) Enhances PC12 Cell Hypoxia Injury by Targeting MiR-147 , 2017, Cellular Physiology and Biochemistry.
[7] Stuart L. Schreiber,et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition , 2017, Nature.
[8] Sydney M. Shaffer,et al. Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance , 2017, Nature.
[9] F. Slack,et al. Targeting noncoding RNAs in disease , 2017, The Journal of clinical investigation.
[10] F. Slack,et al. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases , 2017, Nature Reviews Drug Discovery.
[11] M. Boutros,et al. Wnt signaling in cancer , 2016, Oncogene.
[12] C. James,et al. Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation. , 2015, Cell reports.
[13] Jordan Anaya,et al. OncoRank: A pan-cancer method of combining survival correlations and its application to mRNAs, miRNAs, and lncRNAs , 2016 .
[14] R. Xavier,et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages , 2016, Cell.
[15] Jianguo Xia,et al. Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis , 2016, Current protocols in bioinformatics.
[16] J. Cheng,et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner , 2016, Science.
[17] F. Slack,et al. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. , 2016, Cell stem cell.
[18] M. Haigis,et al. Mitochondria and Cancer , 2016, Cell.
[19] B. Lim,et al. Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression , 2016, Nature Communications.
[20] David S. Wishart,et al. Heatmapper: web-enabled heat mapping for all , 2016, Nucleic Acids Res..
[21] Navdeep S. Chandel,et al. Fundamentals of cancer metabolism , 2016, Science Advances.
[22] K. Flaherty,et al. Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy , 2016, Cancer cell.
[23] Bruce A. Posner,et al. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells , 2016, Nature Communications.
[24] B. Faubert,et al. Metabolic Heterogeneity in Human Lung Tumors , 2016, Cell.
[25] G. Getz,et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition , 2016, Nature Medicine.
[26] A. Califano,et al. An ID2-dependent mechanism for VHL inactivation in cancer , 2015, Nature.
[27] Hao Liu,et al. MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. , 2015, International journal of oncology.
[28] Eyal Gottlieb,et al. Oncometabolites: tailoring our genes , 2015, The FEBS journal.
[29] Aleksandra Markovets,et al. Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M , 2015, Nature Medicine.
[30] Gail H Deutsch,et al. In vitro generation of human pluripotent stem cell derived lung organoids , 2015, eLife.
[31] Thomas D. Wu,et al. A comprehensive transcriptional portrait of human cancer cell lines , 2014, Nature Biotechnology.
[32] G. Semenza,et al. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells , 2014, Proceedings of the National Academy of Sciences.
[33] P. Schumacker,et al. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? , 2014, Nature Reviews Cancer.
[34] F. Ishikawa,et al. Human cancer growth and therapy in immunodeficient mouse models. , 2014, Cold Spring Harbor protocols.
[35] Steven J. M. Jones,et al. Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.
[36] T. Tan,et al. FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway , 2014, Cell Death and Disease.
[37] B. Lim,et al. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. , 2014, Biochemistry.
[38] T. Yeatman,et al. MicroRNA-147 Induces a Mesenchymal-To-Epithelial Transition (MET) and Reverses EGFR Inhibitor Resistance , 2014, PloS one.
[39] E. Mercken,et al. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging , 2013, Cell.
[40] J. Engelman,et al. Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer , 2013, Science Signaling.
[41] David G Hendrickson,et al. Differential analysis of gene regulation at transcript resolution with RNA-seq , 2012, Nature Biotechnology.
[42] W. Kim,et al. Clinical investigation of EGFR mutation detection by pyrosequencing in lung cancer patients. , 2013, Oncology letters.
[43] Jane Fridlyand,et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors , 2012, Nature.
[44] V. Mootha,et al. Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation , 2012, Science.
[45] J. Asara,et al. A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue , 2012, Nature Protocols.
[46] P. Ward,et al. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.
[47] P. Robson,et al. Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis , 2012, Cell.
[48] Brian Keith,et al. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression , 2011, Nature Reviews Cancer.
[49] G. Shadel,et al. Revisiting the TCA cycle: signaling to tumor formation. , 2011, Trends in molecular medicine.
[50] E. Liu,et al. Pyrosequencing enhancement for better detection limit and sequencing homopolymers. , 2010, Biochemical and biophysical research communications.
[51] Kwok-Kin Wong,et al. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. , 2010, Cell stem cell.
[52] Junjie Chen,et al. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. , 2010, Molecular cell.
[53] Ben S. Wittner,et al. A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations , 2010, Cell.
[54] E. Barillot,et al. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. , 2010, Cancer research.
[55] M. Robinson,et al. A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.
[56] G. Smyth,et al. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. , 2009, Journal of immunological methods.
[57] L. Cantley,et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.
[58] Cole Trapnell,et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.
[59] W. Kaelin. The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer , 2008, Nature Reviews Cancer.
[60] W. Krek,et al. pVHL: A Multipurpose Adaptor Protein , 2008, Science Signaling.
[61] A. Tanswell,et al. A Critical Role for Fibroblast Growth Factor-7 during Early Alveolar Formation in the Neonatal Rat , 2008, Pediatric Research.
[62] S. Nishikawa,et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells , 2007, Nature Biotechnology.
[63] E. Gottlieb,et al. Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells , 2007, Molecular and Cellular Biology.
[64] F. Slack,et al. Oncomirs — microRNAs with a role in cancer , 2006, Nature Reviews Cancer.
[65] P. M. Nissom,et al. A novel normalization method for effective removal of systematic variation in microarray data , 2006, Nucleic acids research.
[66] J. Aragonés,et al. Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase* , 2005, Journal of Biological Chemistry.
[67] M. Meyerson,et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. , 2005, The New England journal of medicine.
[68] H. Varmus,et al. Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain , 2005, PLoS medicine.
[69] H. Varmus,et al. KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib , 2005, PLoS medicine.
[70] David G. Watson,et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.
[71] S. Gabriel,et al. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.
[72] W. Kaelin,et al. Molecular basis of the VHL hereditary cancer syndrome , 2002, Nature Reviews Cancer.
[73] W. Hahn,et al. Immortalization and transformation of primary human airway epithelial cells by gene transfer , 2002, Oncogene.
[74] M. Ivan,et al. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.
[75] Michael I. Wilson,et al. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.
[76] Nobuyuki Itoh,et al. Fgf10 is essential for limb and lung formation , 1999, Nature Genetics.
[77] C. Betsholtz,et al. PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis , 1996, Cell.
[78] C. Veeger,et al. STUDIES ON SUCCINATE DEHYDROGENASE. I. SPECTRAL PROPERTIES OF THE PURIFIED ENZYME AND FORMATION OF ENZYME-COMPETITIVE INHIBITOR COMPLEXES. , 1964, Biochimica et biophysica acta.