A controlled trial of ambroxol in chronic bronchitis.

Ambroxol is a mucolytic agent which is widely used in chronic bronchitis in Europe. We conducted a double-blind randomized controlled trial of ambroxol vs matched placebo in 90 patients with chronic bronchitis and difficulty clearing secretions. It was concluded that there was no advantage to taking ambroxol.

[1]  [Effect of bromohexine metabolite 8 and a new adrenergic agent on the mucociliary function of the respiratory tract]. , 1974, Arzneimittel-Forschung.

[2]  Indication of increase of the lecithin/sphingomyelin (L/S) ratio in lung fluid of lambs maternally treated with metabolite VIII of Bisolvon. , 1976, Biology of the neonate.

[3]  Y. Kapanci,et al.  Effects of metabolite VIII of bromexine (Na 872) on type II epithelium of the lung: an experimental and morphological study with reference to surfactant secretion. , 1979, Respiration; international review of thoracic diseases.

[4]  Effects of a beta adrenergic drug and a secretolytic agent on regional mucociliary clearance in patients with COLD. , 1981, Chest.

[5]  Morphological Approach to Surfactant Secretion in the Lungs with Particular Reference to Ambroxol1 , 1981 .

[6]  Lung compliance and alveolar expansion in the artificially ventilated premature newborn rabbit after maternal treatment with ambroxol. , 1981, Respiration; international review of thoracic diseases.

[7]  Study on the influence of NA-872 (ambroxol) and dexamethasone on the differentiation of Clara cells in albino mice. , 1982, Respiration; international review of thoracic diseases.

[8]  Influence of transplacental NA-872 and dexamethasone therapy on fetal and newborn mouse lung. , 1982, Respiration; international review of thoracic diseases.

[9]  T. Takishima,et al.  Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo. , 1983, Biorheology.

[10]  A. Fietta,et al.  Biomedical and functional changes in bronchoalveolar parameters induced by ambroxol treatment of chronic bronchitis , 1983 .

[11]  L. Allegra,et al.  Influence of surfactant on mucociliary transport. , 1985, European journal of respiratory diseases. Supplement.

[12]  B Kirshner,et al.  A methodological framework for assessing health indices. , 1985, Journal of chronic diseases.

[13]  G. Guyatt,et al.  Should study subjects see their previous responses? , 1985, Journal of chronic diseases.

[14]  Pharmacological stimulation of surfactant secretion and surfactant replacement. , 1985, European journal of respiratory diseases. Supplement.

[15]  A. Detsky,et al.  When was a "negative" clinical trial big enough? How many patients you needed depends on what you found. , 1985, Archives of internal medicine.

[16]  Improvement of mucociliary transport in smokers by mucolytics. , 1985, European journal of respiratory diseases. Supplement.

[17]  Stimulation of lung maturity: investigation of ambroxol in various animal models. , 1985, Acta physiologica Hungarica.

[18]  B. Mossberg,et al.  Ambroxol therapy in simple chronic bronchitis: effects on subjective symptoms and ventilatory function. , 1986, European journal of respiratory diseases.

[19]  G. Guyatt,et al.  Measuring disease-specific quality of life in clinical trials. , 1986, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.