An optical coherence microscope with enhanced resolving power

Abstract A new configuration of an optical coherence microscope for high-resolution imaging of biological tissues and other scattering materials is described. The microscope employs multiple sources and detectors combined with high-numerical-aperture optics to suppress speckle fluctuations and enhance resolution. Results of experiments on living tissue and tissue phantoms are presented to demonstrate the design principles of the microscope and to compare its performance to that of a conventional optical coherence microscope.

[1]  Yunjiang Rao,et al.  Synthesized source for white-light sensing systems. , 1993, Optics letters.

[2]  J. Duker,et al.  Imaging of macular diseases with optical coherence tomography. , 1995, Ophthalmology.

[3]  J. Fujimoto,et al.  High-speed optical coherence domain reflectometry. , 1992, Optics letters.

[4]  B. Golubovic,et al.  Single mode fiber-optic catheter/endoscope for optical coherence tomography , 1996, Summaries of papers presented at the Conference on Lasers and Electro-Optics.

[5]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[6]  C. Burckhardt.  Speckle in ultrasound B-mode scans , 1978, IEEE Transactions on Sonics and Ultrasonics.

[7]  J G Fujimoto,et al.  High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al(2)O(3) laser source. , 1995, Optics letters.

[8]  A. Fercher,et al.  Eye-length measurement by interferometry with partially coherent light. , 1988, Optics letters.

[9]  J M Schmitt,et al.  Subsurface imaging of living skin with optical coherence microscopy. , 1995, Dermatology.

[10]  J. Fujimoto,et al.  Optical biopsy and imaging using optical coherence tomography , 1995, Nature Medicine.

[11]  J. Schmitt,et al.  Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering. , 1994, Physics in medicine and biology.

[12]  Coherent 1-microm lidar measurements of atmospheric-turbulence-induced spatial decorrelation using a multielement heterodyne detector array. , 1992, Applied optics.