A new synthesis of the labeling precursor for [18F]- fluoromisonidazole

[18F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [18F]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%. Copyright © 2005 John Wiley & Sons, Ltd.

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