Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

[1]  E. Lander,et al.  Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. , 2008, Cancer research.

[2]  Ellen M. Langer,et al.  Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. , 2008, Developmental cell.

[3]  Kou-Juey Wu,et al.  Direct regulation of TWIST by HIF-1α promotes metastasis , 2008, Nature Cell Biology.

[4]  A. Dimmler,et al.  The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. , 2008, Cancer research.

[5]  E. Sahai,et al.  Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells , 2007, Nature Cell Biology.

[6]  R. Foisner,et al.  The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity , 2007, Oncogene.

[7]  Ellen M. Langer,et al.  The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. , 2007, Cancer research.

[8]  A. Nawshad,et al.  Mechanisms of palatal epithelial seam disintegration by transforming growth factor (TGF) β3 , 2007 .

[9]  Marta Costa,et al.  Bmp2 is required for migration but not for induction of neural crest cells in the mouse , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[10]  V. Montel,et al.  uPAR induces epithelial–mesenchymal transition in hypoxic breast cancer cells , 2007, The Journal of cell biology.

[11]  D. Kimelman,et al.  Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation. , 2007, Genes & development.

[12]  Alicia Zhou,et al.  Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers , 2007, Proceedings of the National Academy of Sciences.

[13]  D. Montell,et al.  Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging. , 2007, Developmental cell.

[14]  Raymond B. Runyan,et al.  Multiple Transforming Growth Factor-β Isoforms and Receptors Function during Epithelial-Mesenchymal Cell Transformation in the Embryonic Heart , 2007, Cells Tissues Organs.

[15]  Héctor Peinado,et al.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? , 2007, Nature Reviews Cancer.

[16]  Riccardo Fodde,et al.  Wnt/β-catenin signaling in cancer stemness and malignant behavior , 2007 .

[17]  Anne E Carpenter,et al.  The Spemann organizer gene, Goosecoid, promotes tumor metastasis , 2006, Proceedings of the National Academy of Sciences.

[18]  D. Raible.  Development of the neural crest: achieving specificity in regulatory pathways. , 2006, Current opinion in cell biology.

[19]  Gema Moreno-Bueno,et al.  Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. , 2006, Cancer research.

[20]  K. Anderson,et al.  p38 and a p38-Interacting Protein Are Critical for Downregulation of E-Cadherin during Mouse Gastrulation , 2006, Cell.

[21]  D. Kimelman.  Mesoderm induction: from caps to chips , 2006, Nature Reviews Genetics.

[22]  G. Christofori,et al.  Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. , 2006, Cancer cell.

[23]  M. Matzuk,et al.  The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo , 2005, Development.

[24]  Judith S Eisen,et al.  Notch in the pathway: the roles of Notch signaling in neural crest development. , 2005, Seminars in cell & developmental biology.

[25]  D. Tarin,et al.  The fallacy of epithelial mesenchymal transition in neoplasia. , 2005, Cancer research.

[26]  D. Tarin,et al.  Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? , 2005, Cancer research.

[27]  C. Corless,et al.  Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. , 2005, The Journal of clinical investigation.

[28]  R. Mayor,et al.  Essential role of non-canonical Wnt signalling in neural crest migration , 2005, Development.

[29]  V. Vasioukhin.  Faculty Opinions recommendation of Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. , 2005 .

[30]  G. Berx,et al.  DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells , 2005, Oncogene.

[31]  Natasa Przulj,et al.  High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells , 2005, Science.

[32]  Yue Zhang,et al.  Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.

[33]  P. S. Klein,et al.  Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus. , 2005, Developmental biology.

[34]  A. Puisieux,et al.  Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells. , 2004, Cancer cell.

[35]  M. Hung,et al.  Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition , 2004, Nature Cell Biology.

[36]  S. Ariyan,et al.  Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas , 2004, Cancer Research.

[37]  S. Ariyan,et al.  Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. , 2004, Cancer research.

[38]  S. Ramaswamy,et al.  Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.

[39]  J. Zavadil,et al.  Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition , 2004 .

[40]  K. Green.  Faculty Opinions recommendation of Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. , 2004 .

[41]  J. Epstein,et al.  Molecular markers of cardiac endocardial cushion development , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[42]  M. Metzstein,et al.  Branching morphogenesis of the Drosophila tracheal system. , 2003, Annual review of cell and developmental biology.

[43]  A. Ben-Ze'ev,et al.  Autoregulation of E-cadherin expression by cadherin–cadherin interactions , 2003, The Journal of cell biology.

[44]  Thomas Waerner,et al.  Expression profiling of epithelial plasticity in tumor progression , 2003, Oncogene.

[45]  E. Cuppen,et al.  The Wnt/β-catenin pathway regulates cardiac valve formation , 2003, Nature.

[46]  H. Beug,et al.  Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis , 2003, Nature Reviews Molecular Cell Biology.

[47]  W. Birchmeier,et al.  How to make tubes: signaling by the Met receptor tyrosine kinase. , 2003, Trends in cell biology.

[48]  L. Nelles,et al.  Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. , 2003, American journal of human genetics.

[49]  Birgit Luber,et al.  Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. , 2002, The American journal of pathology.

[50]  C. Marcelle,et al.  Ectodermal Wnt Function as a Neural Crest Inducer , 2002, Science.

[51]  S. Klewer,et al.  Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors , 2002, Nature Medicine.

[52]  R. Behringer,et al.  Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. , 2002, Developmental biology.

[53]  J. Thiery.  Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.

[54]  J. Gutkind,et al.  E-cadherin and Hakai: signalling, remodeling or destruction? , 2002, Nature Cell Biology.

[55]  E. Fearon,et al.  The SLUG zinc-finger protein represses E-cadherin in breast cancer. , 2002, Cancer research.

[56]  W. Birchmeier,et al.  Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex , 2002, Nature Cell Biology.

[57]  M. Nieto,et al.  The snail superfamily of zinc-finger transcription factors , 2002, Nature Reviews Molecular Cell Biology.

[58]  J. Downward,et al.  Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis , 2002, The Journal of Cell Biology.

[59]  E. Carver,et al.  The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition , 2001, Molecular and Cellular Biology.

[60]  M. Nieto,et al.  A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions* , 2001, The Journal of Biological Chemistry.

[61]  J. Rossant,et al.  FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. , 2001, Developmental cell.

[62]  G. Berx,et al.  The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. , 2001, Molecular cell.

[63]  Francisco Portillo,et al.  The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression , 2000, Nature Cell Biology.

[64]  A. G. Herreros,et al.  The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells , 2000, Nature Cell Biology.

[65]  A. Børresen-Dale,et al.  Re‐expression of E‐cadherin, α‐catenin and β‐catenin, but not of γ‐catenin, in metastatic tissue from breast cancer patients , 2000 .

[66]  Allan Bradley,et al.  Requirement for Wnt3 in vertebrate axis formation , 1999, Nature Genetics.

[67]  J. Gurdon,et al.  Activin as a morphogen in Xenopus mesoderm induction. , 1999, Seminars in cell & developmental biology.

[68]  D. L. Weeks,et al.  TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. , 1999, Developmental biology.

[69]  C. Birchmeier,et al.  The role of SF/HGF and c-Met in the development of skeletal muscle. , 1999, Development.

[70]  C. Birchmeier,et al.  THE ROLE OF SF/HGF AND C-MET IN THE MIGRATION OF MYOGENIC PRECURSOR CELLS DURING DEVELOPMENT OF THE TONGUE, THE LIMBS AND THE DIAPHRAGM(Developmental Biology)(Proceedings of the Sixty-Ninth Annual Meeting of the Zoological Society of Japan) , 1998 .

[71]  H. Beug,et al.  TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis , 1998, Current Biology.

[72]  A. Børresen-Dale,et al.  E‐cadherin and α‐, β‐, and γ‐catenin protein expression in relation to metastasis in human breast carcinoma , 1998 .

[73]  Anthony E. Reeve,et al.  E-cadherin germline mutations in familial gastric cancer , 1998, Nature.

[74]  Gerhard Christofori,et al.  A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.

[75]  J. Schalken,et al.  Role of E boxes in the repression of E-cadherin expression. , 1997, Biochemical and biophysical research communications.

[76]  S. Shah,et al.  Misexpression of chick Vg1 in the marginal zone induces primitive streak formation. , 1997, Development.

[77]  S. Roche,et al.  Src and Ras are involved in separate pathways in epithelial cell scattering , 1997, The EMBO journal.

[78]  I. Gitelman.  Twist protein in mouse embryogenesis. , 1997, Developmental biology.

[79]  J. Davies.  Mesenchyme to epithelium transition during development of the mammalian kidney tubule. , 1996, Acta anatomica.

[80]  W. Birchmeier,et al.  Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. , 1995, Oncogene.

[81]  R. Moon,et al.  Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. , 1995, Development.

[82]  R. Behringer,et al.  twist is required in head mesenchyme for cranial neural tube morphogenesis. , 1995, Genes & development.

[83]  E. Hay,et al.  Expression of β1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[84]  J. Thiery,et al.  Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. , 1994, Molecular biology of the cell.

[85]  R. Markwald,et al.  Identification of an extracellular 130-kDa protein involved in early cardiac morphogenesis. , 1993, The Journal of biological chemistry.

[86]  J. Thiery,et al.  Epithelium‐mesenchyme interconversion as example of epithelial plasticity , 1993, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[87]  E. Hay,et al.  Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels. , 1992, Development.

[88]  R. Harland,et al.  Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center , 1991, Cell.

[89]  Douglas A. Melton,et al.  Injected Wnt RNA induces a complete body axis in Xenopus embryos , 1991, Cell.

[90]  M. Mayes,et al.  Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. , 1991, Development.

[91]  M. Leptin.  twist and snail as positive and negative regulators during Drosophila mesoderm development. , 1991, Genes & development.

[92]  W. Birchmeier,et al.  E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells , 1991, The Journal of cell biology.

[93]  M. Leptin,et al.  Cell shape changes during gastrulation in Drosophila. , 1990, Development.

[94]  R R Markwald,et al.  Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex. , 1989, Developmental biology.

[95]  J. Duband,et al.  Cell-adhesion and substrate-adhesion molecules: their instructive roles in neural crest cell migration. , 1988, Development.

[96]  E. Hay,et al.  Cytoskeleton and thyroglobulin expression change during transformation of thyroid epithelium to mesenchyme-like cells. , 1988, Development.

[97]  M. Martins-Green,et al.  Basal lamina is not a barrier to neural crest cell emigration: documentation by TEM and by immunofluorescent and immunogold labelling. , 1987, Development.

[98]  J. Thiery,et al.  Distribution of laminin and collagens during avian neural crest development. , 1987, Development.

[99]  B. Thisse,et al.  The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern. , 1987, Nucleic acids research.

[100]  E. Hay,et al.  Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse. , 1987, Developmental biology.

[101]  E. Hay,et al.  Cytodifferentiation and tissue phenotype change during transformation of embryonic lens epithelium to mesenchyme-like cells in vitro. , 1986, Developmental biology.

[102]  E. Hay,et al.  Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells , 1982, The Journal of cell biology.

[103]  D. Nichols.  Neural crest formation in the head of the mouse embryo as observed using a new histological technique. , 1981, Journal of embryology and experimental morphology.

[104]  E. Sanders.  Development of the basal lamina and extracellular materials in the early chick embryo , 1979, Cell and Tissue Research.

[105]  Raymond B. Runyan,et al.  Cell biology of cardiac cushion development. , 2005, International review of cytology.

[106]  A. G. Gittenberger-de Groot,et al.  The extracellular matrix during neural crest formation and migration in rat embryos , 2004, Anatomy and Embryology.

[107]  Frank McCormick,et al.  Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. , 2004, Genes & development.

[108]  E. Dejana,et al.  -Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse , 2004 .

[109]  J. Zavadil,et al.  Integration of TGF- b /Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition , 2004 .

[110]  M. Quintanilla,et al.  Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. , 2003, The Journal of biological chemistry.

[111]  J. Downward,et al.  Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. , 2002, The Journal of cell biology.

[112]  W. Birchmeier,et al.  Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells. , 1997, Ciba Foundation symposium.

[113]  B. Gumbiner,et al.  Molecular and functional analysis of cadherin-based adherens junctions. , 1997, Annual review of cell and developmental biology.

[114]  C. Viebahn.  Epithelio-mesenchymal transformation during formation of the mesoderm in the mammalian embryo. , 1995, Acta anatomica.

[115]  C. Viebahn,et al.  Morphology of incipient mesoderm formation in the rabbit embryo: a light- and retrospective electron-microscopic study. , 1995, Acta anatomica.

[116]  E. Hay.  An overview of epithelio-mesenchymal transformation. , 1995, Acta anatomica.

[117]  D. Newgreen,et al.  Epithelium-mesenchyme transition during neural crest development. , 1995, Acta anatomica.

[118]  Privatdozent Dr. Henning Schmalbruch.  Skeletal Muscle , 1985, Handbook of Microscopic Anatomy.

[119]  R. Markwald,et al.  Epithelial-mesenchymal transformation in chick atrioventricular cushion morphogenesis. , 1979, Scanning electron microscopy.

[120]  R. Markwald,et al.  Structural development of endocardial cushions. , 1977, The American journal of anatomy.