Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
暂无分享,去创建一个
C. Farley | H. Davis | L. Hoos | K. Alton | E. Sybertz | M. van Heek | D. Compton
[1] P. Dawson,et al. Intestinal cholesterol absorption. , 1999, Current opinion in lipidology.
[2] R. Collins,et al. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. , 1998, The New England journal of medicine.
[3] J. Clader,et al. Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. , 1998, Journal of medicinal chemistry.
[4] H. Davis,et al. In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. , 1997, The Journal of pharmacology and experimental therapeutics.
[5] B. Davis,et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. , 1996, The New England journal of medicine.
[6] A. Somogyi,et al. The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. , 1996, Drug metabolism reviews.
[7] R. Miller,et al. Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine. , 1995, The Journal of pharmacology and experimental therapeutics.
[8] R. Burrier,et al. Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461. , 1995, Atherosclerosis.
[9] R. Burrier,et al. Effect of the cholesterol absorption inhibitor SCH48461 in combination with the HMG-CoA reductase inhibitor lovastatin in rabbits, dogs and rhesus monkeys , 1994 .
[10] R. Burrier,et al. SCH 48461, a novel inhibitor of cholesterol absorption , 1994 .
[11] R. Burrier,et al. 2-Azetidinones as inhibitors of cholesterol absorption. , 1994, Journal of medicinal chemistry.
[12] J. Stengård,et al. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease , 1994, The Lancet.
[13] P. B. Marsh. Implications for Reducing Chronic Disease Risk . 1989. Anon. National Academy Press, National Research Council, 2101 Constitution Avenue, NW, Washington, DC. 749 pp. , 1991 .
[14] D. Back,et al. Review: first‐pass metabolism by the gastrointestinal mucosa , 1987, Alimentary pharmacology & therapeutics.
[15] J. Folch,et al. A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.
[16] Ames,et al. PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA , 2000 .
[17] P. Macfarlane,et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. , 1995, The New England journal of medicine.