Epstein-Barr virus--associated smooth muscle tumor mimicking cutaneous angioleiomyoma.

We present a case of a subcutaneous, unifocal, Epstein-Barr virus--associated smooth muscle tumor mimicking a cutaneous angioleiomyoma. The patient was immunocompromised due to a renal transplant. The tumor displayed diffuse and strong immunoreactivity for smooth muscle actin, H-caldesmon; focal positivity for desmin; and strong and diffuse positivity for Epstein--Barr virus RNA on in situ hybridization. This unique presentation emphasizes the importance of considering this pathologic entity when solitary smooth muscle tumors with the histological features of an angioleiomyoma are encountered in immunocompromised patients.

[1]  J. Krejci-Manwaring,et al.  Epstein‐Barr virus is not associated with angioleiomyomas, or other cutaneous smooth muscle tumors in immunocompetent individuals , 2010, Journal of cutaneous pathology.

[2]  Ashok K. Gupta,et al.  Leiomyosarcoma of the Larynx: Case Report and Review of the Literature , 2008, Ear, nose, & throat journal.

[3]  A. Deyrup.  Progress in pathology Epstein-Barr virus – associated epithelial and mesenchymal neoplasms , 2008 .

[4]  J. Calderaro,et al.  Multifocal Epstein Barr virus (EBV)‐associated myopericytoma in a patient with AIDS , 2008, Neuropathology and applied neurobiology.

[5]  S. Weiss,et al.  Epstein-Barr Virus-Associated Smooth Muscle Tumors Are Distinctive Mesenchymal Tumors Reflecting Multiple Infection Events: A Clinicopathologic and Molecular Analysis of 29 Tumors From 19 Patients , 2006, The American journal of surgical pathology.

[6]  R. Ambinder.  Epstein-Barr virus-associated lymphoproliferative disorders. , 2003, Reviews in clinical and experimental hematology.

[7]  C. Hung,et al.  Multiple Epstein–Barr virus‐associated subcutaneous angioleiomyomas in a patient with acquired immunodeficiency syndrome , 2002, The British journal of dermatology.

[8]  L. Young,et al.  The Epstein-Barr virus and its association with human cancers. , 1999, Molecular pathology : MP.

[9]  S. Fan,et al.  Intra‐abdominal follicular dendritic cell tumour: a rare tumour in need of recognition , 1998, Histopathology.

[10]  I. Ng,et al.  Follicular dendritic cell tumor of the liver. Evidence for an Epstein-Barr virus-related clonal proliferation of follicular dendritic cells. , 1996, The American journal of surgical pathology.

[11]  J. Locker,et al.  The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. , 1995, The New England journal of medicine.

[12]  R. Parmley,et al.  Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS. , 1995, The New England journal of medicine.

[13]  R. Parmley,et al.  Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS. , 1997, Leukemia & lymphoma.