Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis.

BACKGROUND Epidemiological studies evaluating the association between cruciferous vegetables (CVs) intake and female lung cancer risk have produced inconsistent results. PATIENTS AND METHODS This study followed 74 914 Chinese women aged 40-70 years who participated in the Shanghai Women's Health Study. CV intake was assessed through a validated food-frequency questionnaire (FFQ) at baseline and reassessed during follow-up. Hazard ratios (HRs) and 95% confidence interval (CIs) were estimated by using Cox proportional hazards models. Furthermore, we carried out a meta-analysis of all observational studies until December 2011. RESULTS After excluding the first 2 years of follow-up, 417 women developed lung cancer over a mean of 11.1 years of follow-up. An inverse association of borderline statistical significance was observed between CV consumption and female lung cancer risk, with HR for the highest compared with the lowest quartiles of 0.73 (95% CI 0.54-1.00, P trend = 0.1607). The association was strengthened in analyses restricting to never smokers, with the corresponding HR of 0.59 (95% CI 0.40-0.87, P trend = 0.0510). The finding of an inverse association between CV intake and lung cancer risk in women was supported by our meta-analysis of 10 included studies. CONCLUSIONS Our study suggests that CV consumption may reduce the risk of lung cancer in women, particularly among never smokers.

[1]  J. Blay,et al.  Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[2]  M. Teh,et al.  Meat Consumption and Risk of Lung Cancer Among Never-Smoking Women , 2011, Nutrition and cancer.

[3]  Sander Greenland,et al.  A Procedure to Tabulate and Plot Results after Flexible Modeling of a Quantitative Covariate , 2011 .

[4]  T. Lam,et al.  Cruciferous Vegetable Intake and Lung Cancer Risk: A Nested Case-Control Study Matched on Cigarette Smoking , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[5]  Wael A Sakr,et al.  Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy. , 2010, Current drug targets.

[6]  C. Ambrosone,et al.  Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study , 2010, BMC Cancer.

[7]  S. Chanock,et al.  Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. , 2010, Carcinogenesis.

[8]  M. Bottai,et al.  Logistic quantile regression for bounded outcomes , 2010, Statistics in medicine.

[9]  J. Herman,et al.  Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review , 2009, Cancer Epidemiology Biomarkers & Prevention.

[10]  Yikyung Park,et al.  Intakes of fruit, vegetables, and specific botanical groups in relation to lung cancer risk in the NIH-AARP Diet and Health Study. , 2008, American journal of epidemiology.

[11]  François G. Meyer,et al.  Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies , 2008, Annals of Internal Medicine.

[12]  Erika Avila-Tang,et al.  Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 Cohorts and 22 Cancer Registry Studies , 2008, PLoS medicine.

[13]  David E. Williams,et al.  Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. , 2007, Pharmacological research.

[14]  S. Gapstur,et al.  Cancer Epidemiology and Prevention, 3rd Edition , 2007 .

[15]  A. Wolk,et al.  Long-term physical activity and lower urinary tract symptoms in men. , 2006, The Journal of urology.

[16]  J. Fraumeni,et al.  Cancer epidemiology and prevention. , 2006 .

[17]  Harri Vainio,et al.  Fruit and Vegetables in Cancer Prevention , 2006, Nutrition and cancer.

[18]  B. Högstedt,et al.  Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. , 2005, European journal of cancer.

[19]  P. Brennan,et al.  Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach , 2005, The Lancet.

[20]  M. Chan-yeung,et al.  Lung cancer epidemiology and risk factors in Asia and Africa. , 2004, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[21]  S. McNaughton,et al.  Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables , 2003, British Journal of Nutrition.

[22]  M. Spitz,et al.  Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. , 2003, Lung cancer.

[23]  F. Chung,et al.  Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. , 2002, Current drug metabolism.

[24]  Y. Mao,et al.  Risk factors for lung cancer among Canadian women who have never smoked. , 2002, Cancer detection and prevention.

[25]  D. Stram,et al.  Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers? , 2002, American journal of epidemiology.

[26]  M. Teh,et al.  Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: Evidence for a protective effect of soy in nonsmokers , 2002, International journal of cancer.

[27]  R. Tiwari,et al.  Abrogation of Estrogen-Mediated Cellular and Biochemical Effects by Indole-3-Carbinol , 2001, Nutrition and cancer.

[28]  W. Willett,et al.  Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. , 2000, Journal of the National Cancer Institute.

[29]  M. Spitz,et al.  Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[30]  E. Rosen,et al.  Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells , 2000, Breast Cancer Research and Treatment.

[31]  G. Coetzee,et al.  Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China , 2000, The Lancet.

[32]  S. Hecht,et al.  INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES* , 2000, Drug metabolism reviews.

[33]  S. Hecht,et al.  Effects of watercress consumption on urinary metabolites of nicotine in smokers. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[34]  S. Hecht,et al.  Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. , 1999, The Journal of nutrition.

[35]  P. Amouyel,et al.  Cigarette smoking is associated with unhealthy patterns of nutrient intake: a meta-analysis. , 1998, The Journal of nutrition.

[36]  N. Malats,et al.  Vegetable and fruit intake and the risk of lung cancer in women in Barcelona, Spain. , 1997, European journal of cancer.

[37]  W. Jongen,et al.  Effects of processing conditions on glucosinolates in cruciferous vegetables. , 1997, Cancer letters.

[38]  M. Inoue,et al.  Protective Effects of Raw Vegetables and Fruit against Lung Cancer among Smokers and Ex‐smokers: A Case‐Control Study in the Tokai Area of Japan , 1993, Japanese journal of cancer research : Gann.

[39]  J. Potter,et al.  Vegetables, fruit, and lung cancer in the Iowa Women's Health Study. , 1993, Cancer research.

[40]  S. Amin,et al.  Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. , 1989, Carcinogenesis.

[41]  L. Wattenberg.  Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. , 1987, Carcinogenesis.

[42]  A. D. De Paula.  CANCER OF THE LUNG , 1959, Revista brasileira de tuberculose e doencas toracicas.

[43]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[44]  L. Koo.  Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. , 1988, Nutrition and cancer.