An efficient one-pot synthesis of dispiropyrrolidine derivatives through 1,3-dipolar cycloaddition reactions under ultrasound irradiation

A series of dispiropyrrolidine derivatives were synthesized via the three-component 1,3-dipolar cycloaddition reaction of isatin, sarcosine and 5-arylidene-1,3-thiazolidine-2,4-dione or 5-arylidene-4-thioxo-1,3-thiazolidine-2-one in ethanol under ultrasound irradiation. This protocol has the advantages of mild reaction conditions, higher yields, and shorter reaction time. J. Heterocyclic Chem., (2011).

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