Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting

Abstract Experiments were conducted to elucidate the role of the noradrenergic neurotransmitter system in arousal and the orienting of attention. Rhesus monkeys were trained to perform a peripherally cued, covert orienting task for juice reward, and their manual reaction times (RTs) to visual stimuli were measured. The effects of parenteral injections of the α-2 adrenergic agonists clonidine and guanfacine, and normal saline were compared on the covert task. We assessed 1) overall error rates, 2) the difference in RTs between validly and invalidly cued trials (validity effect), 3) the difference in RTs between neutral and no-cue trials (alerting effect), 4) target location (visual field), and 5) cue-target interval. Changes in noradrenaline levels produced by clonidine (and to a lesser extent guanfacine) significantly decreased the alerting effect, and lowered RTs to stimuli in the left visual field, but did not change the validity effect, suggesting that noradrenaline is involved in maintaining non-spatial, sensory readiness to external cues but not in the shifting of the attentional focus.

[1]  Stephen J. Boies,et al.  Components of attention. , 1971 .

[2]  B. Bunney,et al.  Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine , 1975, Brain Research.

[3]  M. Posner.  Chronometric explorations of mind : the third Paul M. Fitts lectures, delivered at the University of Michigan, September 1976 , 1978 .

[4]  B. Richmond,et al.  Implantation of magnetic search coils for measurement of eye position: An improved method , 1980, Vision Research.

[5]  M. Goldberg,et al.  Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor. , 1983, Pharmacological reviews.

[6]  J. Jonides,et al.  On the Cost and Benefit of Cost and Benefit , 1984 .

[7]  C. Carter,et al.  Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat. , 1987, The Journal of pharmacology and experimental therapeutics.

[8]  M. Posner,et al.  Asymmetries in hemispheric control of attention in schizophrenia. , 1988, Archives of general psychiatry.

[9]  S. Yantis,et al.  Uniqueness of abrupt visual onset in capturing attention , 1988, Perception & psychophysics.

[10]  P. Goldman-Rakic,et al.  The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  G. Geffen,et al.  Catecholamines and the covert orientation of attention in humans , 1989, Neuropsychologia.

[12]  M. Posner,et al.  The attention system of the human brain. , 1990, Annual review of neuroscience.

[13]  S. Z. Langer,et al.  Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia. , 1990, The Journal of pharmacology and experimental therapeutics.

[14]  L. Quintin,et al.  Effect of clonidine on catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study. , 1991, European journal of pharmacology.

[15]  E. Duzic,et al.  Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype. , 1991, The Journal of biological chemistry.

[16]  T. Robbins,et al.  Forebrain norepinephrine: role in controlled information processing in the rat. , 1992, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[17]  D. Bylund,et al.  Differential localization of alpha 2-adrenergic receptor subtypes in brain. , 1992, Pharmacology, biochemistry, and behavior.

[18]  Á. Pazos,et al.  Quantitative light microscopic autoradiographic localization of α 2-adrenoceptors in the human brain , 1992, Brain Research.

[19]  D. Heal,et al.  Quantification of presynaptic α2-adrenoceptors in rat brain after short-term DSP-4 lesioning , 1993 .

[20]  M. Corbetta,et al.  A PET study of visuospatial attention , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  A. Arnsten,et al.  Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine , 1993, Neurobiology of Aging.

[22]  G. Aston-Jones,et al.  Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  G. Aston-Jones,et al.  Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance , 1994, Brain Research Bulletin.

[24]  J. Wikberg,et al.  Comparison of the binding activities of some drugs on alpha 2A, alpha 2B and alpha 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig. , 1995, Pharmacology & toxicology.

[25]  J. Hieble,et al.  Possible Structural and Functional Relationships between Imidazoline Receptors and α2‐Adrenoceptors , 1995, Annals of the New York Academy of Sciences.

[26]  R. Marrocco,et al.  Visual orienting and alerting in rhesus monkeys: comparison with humans , 1996, Behavioural Brain Research.

[27]  M. Davidson,et al.  Effects of altering brain cholinergic activity on covert orienting of attention: comparison of monkey and human performance , 1997, Psychopharmacology.

[28]  Diego Fernandez-Duque,et al.  Relating the mechanisms of orienting and alerting , 1997, Neuropsychologia.