Abstract The stellarator W7-X will be equipped with two Neutral-Beam-Injector (NBI) boxes for balanced injection. Each NBI box has 2 tangential and 2 radial source positions. For the experimental start-up phase each NBI box will be only equipped with 2 ion sources. For the selection of the initial 2 NBI source positions per box three physical aspects were examined (transmission and duct power deposition, shine through and heating efficiency). Using hydrogen injection the heating power to the plasma under typically planned conditions should be 1.3 MW for the tangential sources and 1.1 MW for the radial sources (deuterium: 2 MW for the tangential sources, 1.8 MW for the radial sources). The tangential source positions all have similar heating efficiencies. One of them suffers from the lowest duct transmission (highest power-load to the duct). The same source hits a component with a low power-load capability. The W7-X inner wall design will be modified in order to enhance the maximum power-load capability of that component. For the radial source positions there is no clear physics advantage of one position over the other. Taking all aspects into consideration the decision was made to use one tangential source and one radial source per box during the experimental start-up phase.