CD4+ T Cell-Receptor Repertoire Diversity is Compromised in the Spleen but Not in the Bone Marrow of Aged Mice Due to Private and Sporadic Clonal Expansions
暂无分享,去创建一个
Wilfred Ndifon | Nir Friedman | Hilah Gal | Eric Shifrut | Aleksandra Deczkowska | Michal Schwartz | N. Friedman | M. Schwartz | Eric Shifrut | H. Gal | W. Ndifon | K. Baruch | A. Deczkowska | Kuti Baruch
[1] M. Blackman,et al. The narrowing of the CD8 T cell repertoire in old age. , 2011, Current opinion in immunology.
[2] F. Miedema,et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. , 2012, Immunity.
[3] Daniel C. Douek,et al. Convergent recombination shapes the clonotypic landscape of the naïve T-cell repertoire , 2010, Proceedings of the National Academy of Sciences.
[4] Rustom Antia,et al. Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age , 2012, Proceedings of the National Academy of Sciences.
[5] F. Greenway,et al. Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance , 2010, The Journal of Immunology.
[6] C. Weyand,et al. Understanding immunosenescence to improve responses to vaccines , 2013, Nature Immunology.
[7] Katherine Kedzierska,et al. Methods for comparing the diversity of samples of the T cell receptor repertoire. , 2007, Journal of immunological methods.
[8] Peter Dalgaard,et al. R Development Core Team (2010): R: A language and environment for statistical computing , 2010 .
[9] C. Weyand,et al. Aging and T-cell diversity , 2007, Experimental Gerontology.
[10] R. Miller,et al. Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice. , 1998, Cellular immunology.
[11] N. Friedman,et al. CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging , 2013, Proceedings of the National Academy of Sciences.
[12] R. Pabst,et al. The bone marrow: a nest for migratory memory T cells. , 2005, Trends in immunology.
[13] Robin Callard,et al. Quantifying Thymic Export: Combining Models of Naive T Cell Proliferation and TCR Excision Circle Dynamics Gives an Explicit Measure of Thymic Output1 , 2009, The Journal of Immunology.
[14] Wilfred Ndifon,et al. Chromatin conformation governs T-cell receptor Jβ gene segment usage , 2012, Proceedings of the National Academy of Sciences.
[15] J. Nikolich-Žugich. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections , 2008, Nature Reviews Immunology.
[16] I. Kang,et al. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine1 , 2004, The Journal of Immunology.
[17] Janko Nikolich- Zcaron,et al. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. , 2008 .
[18] P. Linton,et al. Age-related changes in lymphocyte development and function , 2004, Nature Immunology.
[19] E. Sercarz,et al. Limitations in plasticity of the T-cell receptor repertoire. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[20] A. Lustig,et al. T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis , 2013, Front. Immunol..
[21] Charles P. Lin,et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche , 2011, Nature.
[22] Andreas Radbruch,et al. Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. , 2009, Immunity.
[23] L. Haynes,et al. Effects of aging on T cell function , 2009, Current Opinion in Immunology.
[24] Ramit Mehr,et al. Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution. , 2012, Immunology letters.
[25] R. Ahmed,et al. Bone marrow contains virus-specific cytotoxic T lymphocytes. , 1997, Blood.
[26] M. Blackman,et al. Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice1 , 2009, The Journal of Immunology.
[27] F. Alt,et al. The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.
[28] A. Vallejo,et al. The Influence of Age on T Cell Generation and TCR Diversity1 , 2005, The Journal of Immunology.
[29] David Kipling,et al. Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination , 2012, Front. Immun..
[30] R Core Team,et al. R: A language and environment for statistical computing. , 2014 .
[31] P. Marrack,et al. Unexpected expansions of CD8-bearing cells in old mice. , 1993, Journal of immunology.
[32] Jérôme Lane,et al. IMGT®, the international ImMunoGeneTics information system® , 2004, Nucleic Acids Res..
[33] P. Kourilsky,et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. , 1997, Journal of immunology.
[34] Mushtaq Ahmed,et al. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus , 2008, The Journal of experimental medicine.
[35] P. Doherty,et al. Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations , 2013, Proceedings of the National Academy of Sciences.
[36] R. Würzner,et al. Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+ T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons , 2005, Journal of Virology.
[37] Robert Gentleman,et al. ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput sequence data , 2009, Bioinform..
[38] Achim Zeileis,et al. Measuring Inequality, Concentration, and Poverty , 2014 .
[39] G. Bastert,et al. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow , 2001, Nature Medicine.
[40] M. Davenport,et al. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions , 2011, Proceedings of the National Academy of Sciences.
[41] D. Netanely,et al. Age-dependent spatial memory loss can be partially restored by immune activation. , 2008, Rejuvenation research.
[42] Utpal Banerjee,et al. The hematopoietic stem cell and its niche: a comparative view. , 2007, Genes & development.
[43] Hadley Wickham,et al. ggplot2 - Elegant Graphics for Data Analysis (2nd Edition) , 2017 .