Comparison of efficacy of products containing azelaic acid in melasma treatment

Melasma is one of the most frequently diagnosed hyperpigmentation changes on the skin of women's faces. Nearly 30% of women using oral estrogen therapy struggle with this problem. A common way of reducing melasma is the application of azelaic acid products.

[1]  E. Wlaźlak,et al.  [Long-term use of estrogens: benefit or risk]. , 2015, Postepy higieny i medycyny doswiadczalnej.

[2]  Wei Chen,et al.  Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells , 2011, Steroids.

[3]  E. Camera,et al.  Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARγ activation , 2010, Experimental dermatology.

[4]  P. Puri,et al.  Melasma in men: a clinical, aetiological and histological study , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[5]  S. Passi,et al.  Studies of the genus Pityrosporum in submerged culture , 1973, Mycopathologia et mycologia applicata.

[6]  K. Schallreuter,et al.  A possible mechanism of action for azelaic acid in the human epidermis , 2004, Archives of Dermatological Research.

[7]  S. Sohn,et al.  Melasma: histopathological characteristics in 56 Korean patients , 2002, The British journal of dermatology.

[8]  M. Heenen,et al.  RECURRENT LENTIGO MALIGNA MELANOMA: REGRESSION ASSOCIATED WITH LOCAL AZELAIC ACID 20% , 2002, International journal of clinical practice.

[9]  N. Lowe,et al.  Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. , 1998, Clinical therapeutics.

[10]  K. Gournay,et al.  Body Dysmorphic Disorder , 1996, British Journal of Psychiatry.

[11]  Breathnach As.  Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. , 1996 .

[12]  H. Gollnick,et al.  Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. , 1996, Cutis.

[13]  Q. Nguyen,et al.  AZELAIC ACID: PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES AND ITS THERAPEUTIC ROLE IN HYPERPIGMENTARY DISORDERS AND ACNE , 1995, International journal of dermatology.

[14]  K. Graupe,et al.  The Treatment of Melasma 20% Azelaic Acid versus 4% Hydroquinone Cream , 1991, International journal of dermatology.

[15]  V. Verallo-Rowell,et al.  Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. , 1989, Acta dermato-venereologica. Supplementum.