The Incidence of Clubfoot in the Czech Republic: A Nationwide Epidemiological Study from 2000 to 2014

Clubfoot is one of the most common musculoskeletal birth deformities worldwide. The prevalence varies among individual countries and populations. There is a lack of nationwide incidence studies in Central Europe. We analyzed the incidence of clubfoot in the Czech Republic over 14 years. Patients born with clubfoot in the Czech Republic were identified using The National Registry of Congenital Anomalies. Demographic data were included. Data from 2000 to 2014 were collected and analyzed regarding gender and regional distribution. The study’s chosen time frame was grounded on the condition of the Czech industry. Following extensive transformations in 1989, the industry eliminated highly non-ecological operations with significant environmental impact and related health risks. The incidence of clubfoot during the study period was 1.9 (95% CI 1.8–2.0) per 1000 births; males comprised the majority (59%). The incidence significantly differed among individual regions of the Czech Republic (p < 0.001). The incidence in the Czech Republic was higher than in previous European studies. We found significant regional differences in incidence, which could indicate that there may be exogenous pathogenic factors. For this reason, we plan to follow up our work with an up-to-date study.

[1]  J. M. Castillo-López,et al.  Effectiveness of the Ponseti Method in the Treatment of Clubfoot: A Systematic Review , 2023, International journal of environmental research and public health.

[2]  V. Mosca Clubfoot pathoanatomy—biomechanics of deformity correction: a narrative review , 2021, Annals of translational medicine.

[3]  E. Ippolito,et al.  Clubfoot pathology in fetus and pathogenesis. A new pathogenetic theory based on pathology, imaging findings and biomechanics—a narrative review , 2021, Annals of translational medicine.

[4]  I. Hůnová Ambient Air Quality in the Czech Republic: Past and Present , 2020, Atmosphere.

[5]  M. Loane,et al.  Congenital clubfoot in Europe: A population‐based study , 2019, American journal of medical genetics. Part A.

[6]  V. Pavone,et al.  The etiology of idiopathic congenital talipes equinovarus: a systematic review , 2018, Journal of Orthopaedic Surgery and Research.

[7]  William A. Anderson,et al.  Air Quality Impacts of Petroleum Refining and Petrochemical Industries , 2017 .

[8]  M. Dobbs,et al.  The 2017 ABJS Nicolas Andry Award: Advancing Personalized Medicine for Clubfoot Through Translational Research , 2017, Clinical orthopaedics and related research.

[9]  Adel Al-Jumaily,et al.  Current conservative management and classification of club foot: A review. , 2016, Journal of pediatric rehabilitation medicine.

[10]  E. Dodwell,et al.  Factors Associated With Increased Risk of Clubfoot: A Norwegian National Cohort Analysis , 2015, Journal of pediatric orthopedics.

[11]  J. Herzenberg,et al.  Worldwide spread of the Ponseti method for clubfoot. , 2014, World journal of orthopedics.

[12]  K. Gray,et al.  Update on clubfoot , 2013, Journal of paediatrics and child health.

[13]  G. Grosso,et al.  Congenital talipes equinovarus: an epidemiological study in Sicily , 2012, Acta orthopaedica.

[14]  J. Morcuende,et al.  Epidemiology of congenital idiopathic talipes equinovarus in Iowa, 1997–2005 , 2010, American journal of medical genetics. Part A.

[15]  J. Horáček,et al.  [Birth defects in births in the Czech Republic regions in 1994 - 2007]. , 2010, Ceska gynekologie.

[16]  R. Paton,et al.  Incidence and aetiology of talipes equino-varus with recent population changes. , 2010, Acta orthopaedica Belgica.

[17]  M. Strickland,et al.  Multistate study of the epidemiology of clubfoot. , 2009, Birth defects research. Part A, Clinical and molecular teratology.

[18]  M. Dobbs,et al.  Update on Clubfoot: Etiology and Treatment , 2009, Clinical orthopaedics and related research.

[19]  I. Ponseti,et al.  The Classic: Observations on Pathogenesis and Treatment of Congenital Clubfoot , 2009, Clinical orthopaedics and related research.

[20]  I. Ponseti,et al.  The Classic: Congenital Club Foot: The Results of Treatment , 2009, Clinical orthopaedics and related research.

[21]  A. Connolly,et al.  Impact of congenital talipes equinovarus etiology on treatment outcomes , 2008, Developmental medicine and child neurology.

[22]  J. Kotch,et al.  Maternal smoking and the risk for clubfoot in infants. , 2008, Birth defects research. Part A, Clinical and molecular teratology.

[23]  M. Dobbs,et al.  Use of the Ponseti method for recurrent clubfoot following posteromedial release , 2008, Indian journal of orthopaedics.

[24]  Z. Miedzybrodzka,et al.  Pedigree analysis and epidemiological features of idiopathic congenital talipes equinovarus in the United Kingdom: a case-control study , 2007, BMC musculoskeletal disorders.

[25]  P. Schoenecker,et al.  Long-term follow-up of patients with clubfeet treated with extensive soft-tissue release. , 2006, The Journal of bone and joint surgery. American volume.

[26]  M. Krogsgaard,et al.  Increasing incidence of club foot with higher population density: Incidence and geographical variation in Denmark over a 16–year period—an epidemiological study of 936,525 births , 2006, Acta orthopaedica.

[27]  K. Michaelsson,et al.  Incidence of congenital clubfoot in Sweden , 2006, Acta orthopaedica.

[28]  L. Engesaeter Increasing incidence of clubfoot: changes in the genes or the environment? , 2006, Acta orthopaedica.

[29]  E. Haan,et al.  A South Australian population-based study of congenital talipes equinovarus. , 2005, Paediatric and perinatal epidemiology.

[30]  J. Hecht,et al.  Idiopathic talipes equinovarus (ITEV) (clubfeet) in Texas , 2005, American journal of medical genetics. Part A.

[31]  M. Dobbs,et al.  Factors predictive of outcome after use of the Ponseti method for the treatment of idiopathic clubfeet. , 2004, The Journal of bone and joint surgery. American volume.

[32]  C. Bower,et al.  Talipes equinovarus in Western Australia. , 2003, Paediatric and perinatal epidemiology.

[33]  S. Wientroub,et al.  Efficacy of prenatal ultrasonography in confirmed club foot. , 2002, The Journal of bone and joint surgery. British volume.

[34]  V. Holt,et al.  Talipes equinovarus and maternal smoking: a population-based case-control study in Washington state. , 2002, Teratology.

[35]  J. Herzenberg,et al.  Ponseti Versus Traditional Methods of Casting for Idiopathic Clubfoot , 2002, Journal of pediatric orthopedics.

[36]  E. Renner The Black Triangle Area—Fit for Europe? , 2002, Ambio.

[37]  A. Thelin,et al.  Early Amniocentesis and Congenital Foot Deformities , 2002, Fetal Diagnosis and Therapy.

[38]  M. Macnicol,et al.  Seasonal Distribution of Idiopathic Congenital Talipes Equinovarus in Scotland , 2002, Journal of pediatric orthopedics. Part B.

[39]  C. Moore,et al.  Family history, maternal smoking, and clubfoot: an indication of a gene-environment interaction. , 2000, American journal of epidemiology.

[40]  J. Morcuende,et al.  Treatment of idiopathic clubfoot: an historical review. , 2000, The Iowa orthopaedic journal.

[41]  A. Summers,et al.  Club foot, an adverse outcome of early amniocentesis: disruption or deformation? , 1999, Journal of medical genetics.

[42]  P. Preuss,et al.  Czech Air Quality Monitoring and Receptor Modeling Study , 1995 .